New insights on the relative sea level change during Holocene along the coasts of Tunisia and western Libya from archaeological and geomorphological markers

New data of sea level changes for the Mediterranean region along the coasts of northern Africa are presented. Data are inferred from archaeological sites of Punic-Roman age located along the coast of Tunisia, between Tunis and Jerba island and along the western coast of Libya, between Sabratha and Leptis Magna. Data are based on precise measures of presently submerged archaeological markers that are good indicators of past sea-level elevation. Nineteen selected archaeological sites were studied in Tunisia and four in Libya, all aged between w2.0 and w1.5 ka BP. The functional elevations of significant archaeological markers were measured with respect to the sea level at the time of measurements, applying corrections for tide and atmospheric pressure values. The functional elevations of specific architectural parts of the sites were interpreted, related to sea level at the time of their construction providing data on the relative changes between land and sea. Observations were compared against sea level change predictions derived from the glacio-hydro-isostatic model associated with the Last Glacial cycle. The results indicate that local relative sea level change along the coast of Tunisia and Libya, has increased 0.2 O 0.5 m since the last w2 ka. Besides minor vertical tectonic movements of the land, the observed changes are produced by eustatic and glacio-hydro-isostatic variations acting in the Mediterranean basin since the end of the last glacial maximum

Nonlinear parabolic inequalities on a general convex domain

International audienceThe paper deals with the existence and uniqueness of solutions of some non linear parabolic inequalities in the Orlicz-Sobolev spaces framework

Humanistic burden in schizophrenia: a literature review.

Abstract Objectives of the study and background Schizophrenia is a complex disease that affects 1% of the population. This disease has a considerable impact not only on patients' health and well-being but also on their surrounding environment. The costs of the disease's management remain large for individuals and society. While literature on the economic impact of schizophrenia is abundant, few studies have focused on its humanistic burden. This does not only concern patients, but also caregivers, relatives, neighbours and others in a patient's daily life. This burden appears through several dimensions, including treatment side effects and the impact on caregivers and features of the patient's environment. The aim of this review is to consider, compile and describe the humanistic burden of schizophrenia as documented in the literature. Materials and methods We conducted a literature review assessing the worldwide disease burden of schizophrenia, taking into account all humanistic burden topics. The search considered several databases, including Embase, Medline, Cochrane Library, The German Institute of Medical Documentation and Information (DIMDI) and the ISPOR conference websites. Results The search identified 200 literature reviews, covering several dimensions of humanistic burden and documenting many issues. Main findings included the high death rates that may be explained by long-lasting negative health habits, disease- and treatment-related metabolic disorders, and consequent increased frequencies of cardiovascular diseases. Co-existing depression was found to have adverse consequence on the course of schizophrenia progression, morbidity and mortality. Cognitive impairment also adds to the burden of schizophrenia. Social impairment is worsened by underestimated stigmatisation and lack of corresponding awareness within the professional and social spheres. Finally, caregiver burden was found to be considerable. Discussion Humanistic burden among patients with schizophrenia is substantial potentially impacted by co-morbid depressive symptoms, caregiver burden and cognitive impairment. Effects of treatment on humanistic burden in addition to economic burden need to be explored in future trials

Serum p53 antibodies: predictors of survival in small-cell lung cancer?

Serum p53 antibodies have been shown to be a poor prognostic marker in resected non-small-cell lung cancer (NSCLC), but studies in small-cell lung cancer (SCLC) have been contradictory. We have studied the incidence of p53 antibodies in a large SCLC cohort treated at one oncology centre and correlated the results with survival. 231 patients (63% male, median age 65), diagnosed and treated for SCLC between 1987 and 1994 at The Royal Marsden Hospital NHS Trust, had sera stored pretreatment. All samples were tested for p53 antibodies (p53-Ab) using a standardized ELISA technique with a selection of strongly ELISA positive, weakly ELISA positive and negative samples being confirmed with immunoprecipitation. 54 patients were positive for p53-Ab (23%). The presence of a high titre of p53-Ab (titre ratio >5) appears to be associated with a survival advantage with a relative risk of death of 1.71 (95% CI: 1.14–2.58) in those without the antibody (P = 0.02). This study, the largest homogenous group so far looking at p53-Ab in SCLC, suggests that p53 antibody detection may have a role in predicting outcome in this type of cancer. © 2000 Cancer Research Campaign http://www.bjcancer.co

Alien marine species of Libya: first inventory and new records in El-Kouf National Park (Cyrenaica) and the neighbouring areas

The presence of marine alien species in El-Kouf National Park and the neighbouring areas was assessed using a compilation of available information and observations, a field survey conducted on October 2010 in the framework of the MedMPAnet project and results of further monitoring during June and September 2012. A total of 9 alien species were reported: the Rhodophyta Asparagopsis taxiformis (Delile) Trevisan de Saint-Léon, the Chlorophyta Caulerpa racemosa var. cylindracea (Sonder) Verlaque, Huisman & Boudouresque, the crab Percnon gibbesi (H. Milne-Edwards, 1853) and the fishes Fistularia commersonii Rüppell, 1838, Siganus luridus (Rüppell, 1829), Siganus rivulatus Forsskål, 1775, Pempheris vanicolensis Cuvier, 1831, Lagocephalus sceleratus (Gmelin, 1789) and Sphyraena flavicauda Rüppell, 1838. Several of them were until now unknown for the National Park. The list of alien marine species of Libya is updated and discussed. Until now 63 marine aliens species were recorded along the Libyan coasts. These include 3 Foraminifera, 3 Ochrophyta, 5 Rhodophyta, 5 Chlorophyta, 1 Magnoliophyta, 11 Arthropoda, 13 Mollusca, 1 Echinodermata and 21 Chordata. Among these Non Indigenous Species, 43 are known as established along the Libyan coast including 8 invasive, 11 casual, 6 questionable, 3 cryptogenic and 1 unknown. An in-depth study of the marine organisms would substantially increase the number of alien species occurring in Libya. Monitoring of marine assemblages of MPAs is a valuable opportunity to go further into the knowledge of native and introduced species

Sea level changes in the Mediterranean: tectonic implications

The interpretation of sea level variations along the coasts of the Mediterranean region must be accompanied by the evaluation of vertical land movements associated with seismic and volcanic sources. This can be tentatively carried out through seismic strain analysis based on data pertaining the last 2 millennia as well as from the study of maritime archaeological structures.PublishedHersonissos, Crete island, Greece3.3. Geodinamica e struttura dell'interno della Terraope

Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair

How and when a tumor acquires metastatic properties remain largely unknown. Recent work has uncovered an intricate new mechanism through which transforming growth factor-beta (TGFβ) acts in concert with oncogenic Ras to antagonize p63-metastasis protective function. p63 inhibition requires the combined action of Ras-activated mutant p53 and TGFβ-induced Smads. Mechanistically, it involves the formation of a p63-Smads-mutant p53 ternary complex. Remarkably, just two of the key downstream targets of p63 turn out to be sufficient as a prognostic tool for breast cancer metastasis. Moreover, the molecular mechanism of this inhibition points to novel therapeutic possibilities

Sea level changes and vertical land movements in the Mediterranean from historical and geophysical data and modelling

The Mediterranean basin is a natural laboratory for the reconstruction of the sea level variations since paleo-historical times. During the Holocene, sea level variations in this region have been mainly determined by the response of the geoid and of the solid Earth to the melting of remote ice aggregates, which has produced spatially variable signals mostly governed by the effect of ocean loading. An analysis of past and recent sea level variations is possible from various indicators, which provide data on relative sea level and crustal vertical movements on different time scales.PublishedBurlington house, London3.3. Geodinamica e struttura dell'interno della Terraope

LESIONS PAPULO-PUSTULEUSES PRURIGINEUSES DU VISAGE ASSOCIEES A UNE CONJONCTIVITE CHRONIQUE

We report a case of face localization of demodecidosis wich presented as papulopustular lesion associated to ocular manifestations (chronic blepharitis, chelazian). Demodecidose is induced by Demodex folliculorum. This parasit can induced various clinical pictures as folliculitis; blepharitis, rosaciformes dermatosis. The diagnosis was made by the presence of the parasit on direct examination of skin prelevement. Cyclines seems to be an interesting alternative to acaricides in the treatment of demodecidosis.Notre patient présente une démodécidose du visage sous forme de lésions papulo-pustuleuses associées à une atteinte oculaire à type de blépharite chronique et de chalazion de l’oeil gauche. La démodécidose est due à Demodex folliculorum. Ce parasite peut être associé à différents tableaux cliniques dont les folliculites, les dermites rosacéiformes ou les blépharites. Le diagnostic est conformé par la présence de parasite à l’examen direct. L’emploi de cyclines semble être une alternative intéressante aux acaricides de contact dans la démodécidose

Challenges to the development of antigen-specific breast cancer vaccines

Continued progress in the development of antigen-specific breast cancer vaccines depends on the identification of appropriate target antigens, the establishment of effective immunization strategies, and the ability to circumvent immune escape mechanisms. Methods such as T cell epitope cloning and serological expression cloning (SEREX) have led to the identification of a number target antigens expressed in breast cancer. Improved immunization strategies, such as using dendritic cells to present tumor-associated antigens to T lymphocytes, have been shown to induce antigen-specific T cell responses in vivo and, in some cases, objective clinical responses. An outcome of successful tumor immunity is the evolution of antigen-loss tumor variants. The development of a polyvalent breast cancer vaccine, directed against a panel of tumor-associated antigens, may counteract this form of immune escape