On-Orbit Upset Rate Prediction at Advanced Technology Nodes: a 28 nm FD-SOI Case Study

53rd IEEE Nuclear and Space Radiation Effects Conference (NSREC), Portland, OR, JUL 11-15, 2016International audienceWe address accurate computation of on-orbit upset rates in advanced technologies, with a focus on FD-SOI at the 28 nm node. Heavy-ion measurements performed on FD-SOI SRAM bit-cells give experimental evidence of the technology's intrinsic robustness in space environments; this extreme reduction of sensitive volume dimensions deeply affects the assumptions pertaining to the radiation response models used to predict upset rates. The generic ``Integral Rectangular Parallele Piped''(IRPP) model, although requiring careful setting of its parameters, provides us with first-order estimates of the error rate. We then present a custom FD-SOI response model within our Monte-Carlo simulation chain, enabling comparison with IRPP and further analyses

2D micro-chamber for DC plasma working at low power

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Evaluation of FDG PET/MR in the restaging of colorectal cancer

Annual Congress of the European-Association-of-Nuclear-Medicine, ă Barcelona, SPAIN, OCT 15-19, 2016International audienceno abstrac

Multidetector CT in patients with esophageal stent as a palliative treatment for stenosing esophageal cancer: a feasibility study.

International audienceOBJECTIVE: The self-expanding metallic stent (SEMS) is widely used in the palliative treatment of stenosing esophageal cancer. Multidetector computed tomography (MDCT) allows volumetric investigation including virtual endoscopy. The aim of this study was to determine the feasibility of MDCT follow-up of esophageal SEMS and to describe the imaging patterns encountered as well as correlating them with fibroscopic evaluation. MATERIAL AND METHODS: Thirteen consecutive patients (10 M, mean age 64 years) with esophageal SEMS as a palliative treatment underwent MDCT for recurrent dysphagia (n =7), chest pain and fever (n = 1) or follow-up without symptoms (n = 5). Patency and esophageal wall patterns were studied and compared with diagnosis by fibroscopy. RESULTS: No metallic artefact related to the SEMS was observed. At the SEMS level, MDCT revealed a tissular lump (n = 1), a thin recurrent layer of tissue (n = 1), extrinsic compression (n = 1), fluid stasis (n =7) and intussusception of the gastric wall into the SEMS (n =4). The esophageal wall was analyzed by MDCT (peripheral thickening around the stent (n = 8), tumor overgrowth under or above the SEMS level (n = 8)) and showed tracheal compression (n = 3). At the level of the SEMS, fibroscopy showed tumor recurrence (n = 2), a thin recurrent layer of tissue (n = 1), a distorted SEMS (n = 1) and a tumor overgrowth under or above the SEMS level (n = 6). In comparison with fibroscopy, MDCT satisfactorily diagnosed the SEMS patency in 92% of cases and the esophageal wall in 73%. CONCLUSIONS: Morphology, patency of the SEMS and analysis of the esophageal wall can be performed by MDCT with a good degree of accuracy as compared to fibroscopy. In such patients in palliative care, a non-invasive investigation is worth promoting as a first-line procedure

Composites based on nanoparticle and pan electrospun nanofiber membranes for air filtration and bacterial removal

Often, solid matter is separated from particle-laden flow streams using electrospun filters due to their high specific surface area, good ability to capture aerial particulate matter, and low material costs. Moreover, electrospinning allows incorporating nanoparticles to improve the filter’s air filtration efficiency and bacterial removal. Therefore, a new, improved polyacrylonitrile (PAN) nanofibers membrane that could be used to remove air pollutants and also with antibacterial activity was developed. We engineered three different filters that are characterized by the different particles embedded in the PAN nanofibers: titanium dioxide (TiO2), zinc oxide (ZnO), and silver (Ag). Then, their filtration performance was assessed by quantifying the filtration of sodium chloride (NaCl) aerosol particles of 9 to 300 nm in diameter using a scanning mobility particle sizer. The TiO2_F filter displayed the smallest fiber diameter and the highest filtration efficiency (≈100%). Conversely, the Ag_F filter showed the highest quality factor (≈0.06 Pa−1) because of the lower air pressure drop. The resulting Ag_F nanofibers displayed a very good antibacterial activity using an Escherichia coli suspension (108 CFU/mL). Moreover, the quality factor of these membranes was higher than that of the commercially available nanofiber membrane for air filtration

Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice

AIM: To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice

Expression of Defective Hepatitis B Virus Particles Derived from Singly Spliced RNA Is Related to Liver Disease

International audienceBackground. Defective hepatitis B virus (HBV) particles, generated from singly spliced HBV RNA, have been detected in chronic carriers of HBV. The present study was designed to quantify the expression of defective HBV (dHBV) and wild-type HBV (wtHBV) genomes in the serum of patients with HBV infection and its relation to the severity of liver disease. Methods. HBV and dHBV loads were determined by quantitative polymerase chain reaction in the serum of 89 untreated HBV-infected patients (31 coinfected with human immunodeficiency virus [HIV] type 1) with liver disease of different stages. The ratio of dHBV DNA to total (wtHBV plus dHBV) HBV DNA (dHBV/HBV ratio) was used to express data independently of the level of viral replication. Results. Despite a global correlation between dHBV and wtHBV load, the dHBV/HBV ratio ranged from 0.001% to 69%. The variation in dHBV/HBV ratio was independent of HIV coinfection, HBV genotype, and precore mutations. The mean dHBV/HBV ratio was higher in patients with severe liver necrosis and fibrosis. Conclusions. Our data indicate that an elevated dHBV/HBV ratio is associated with liver necroinflammation and fibrosis disease, suggesting a regulation of dHBV expression according to the severity of the liver disease. The dHBV/ HBV ratio may help to better define liver disease stage during HBV infection

A Postreconstruction Harmonization Method for Multicenter Radiomic Studies in PET

International audienc