Gastric peroral endoscopic myotomy for transthyretin amyloidosis gastroparesis

info:eu-repo/semantics/publishedVersio

LES validation of lock-exchange density currents interacting with an emergent bluff obstacle

Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature B.V.We address the capability of large eddy simulation (LES) to predict the physics of density currents interacting with bluff obstacles. Most density currents of interest in engineering and geophysical applications interact with obstacles or topographic features. Validating LES solutions in these contexts is crucial to establish it as a trusted tool. We thus propose a validation effort based on simple geometries that nonetheless pose challenges common to more complex systems, including boundary layer separation and convective instabilities. We focus on lock-exchange gravity currents in the slumping phase interacting with an emergent vertical circular cylinder. Our main investment was in ensuring that the comparison of experimental data and numerical results include, at least, the velocity and the density fields , and derived quantities (e.g., second order moments). Measurements of both density and velocity fields were performed in the side and plan views for cylinder Reynolds numbers, Red, in the range 1300 to 3475. It was found that the LES accurately predicts the temporal evolution of the current front position. The computed front velocity exhibits a maximum relative error less than 8%. A good agreement between the LES and the experimental size and shape of the current head, and billows was found. The overall features upstream the cylinder, including a reflected wave, adverse pressure gradient and backflow, and downstream the cylinder, including the backflow, wake and the formation of a new head are well reproduced by LES. The agreement between the LES and the experimental time-space evolution of current spanwise- and depth-averaged density contours and the instantaneous velocity fields are not affected by Red.publishersversionpublishe

Recent increasing frequency of compound summer drought and heatwaves in Southeast Brazil

An increase in the frequency of extremely hot and dry events has been experienced over the past few decades in South America, and particularly in Brazil. Regional climate change projections indicate a future aggravation of this trend. However, a comprehensive characterization of drought and heatwave compound events, as well as of the main land-atmosphere mechanisms involved, is still lacking for most of South America. This study aims to fill this gap, assessing for the first time the historical evolution of compound summer drought and heatwave events for the heavily populated region of Southeast Brazil and for the period of 1980-2018. The main goal is to undertake a detailed analysis of the surface and synoptic conditions, as well as of the land-atmosphere coupling processes that led to the occurrence of individual and compound dry and hot extremes. Our results confirm that the Sao Paulo, Rio de Janeiro and Minas Gerais states have recorded pronounced and statistically significant increases in the number of compound summer drought and heatwave episodes. In particular, the last decade was characterized by two austral summer seasons (2013/14 and 2014/15) with outstanding concurrent drought and heatwave conditions stemmed by severe precipitation deficits and a higher-than-average occurrence of blocking patterns. As result of these land and atmosphere conditions, a high coupling (water-limited) regime was imposed, promoting the re-amplification of hot spells that resulted in mega heatwave episodes. Our findings reveal a substantial contribution of persistent dry conditions to heatwave episodes, highlighting the vulnerability of the region to climate change

On the implementation of the gamma function for image correction on a endoscopic camera

This paper describes part of project that implemented the image processing of a CMOS sensor for endoscopic purposes. The sensor is a small sized device of 1x1mm2 and the image processing has been done inside a FPGA. This part of the work describes the implementation of the Gamma function with a balance between the resources needed and the accuracy. A linear piecewise solution was used that stores the values for 31 gamma functions with values ranging from 1 to 4 with 0.1 steps. The solution developed is 10 bit based, was coded in VHDL and is implemented in a Spartan 6 FPGA. The results show that it is an accurate solution that has a small footprint in terms of used resources.info:eu-repo/semantics/publishedVersio

Full image-processing pipeline in field-programmable gate array for a small endoscopic camera

Endoscopy is an imaging procedure used for diagnosis as well as for some surgical purposes. The camera used for the endoscopy should be small and able to produce a good quality image or video, to reduce discomfort of the patients, and to increase the efficiency of the medical team. To achieve these fundamental goals, a small endoscopy camera with a footprint of 1 mm × 1 mm × 1.65 mm is used. Due to the physical prop erties of the sensors and human vision system limitations, different image-processing algorithms, such as noise reduction, demosaicking, and gamma correction, among others, are needed to faithfully reproduce the image or video. A full image-processing pipeline is implemented using a field-programmable gate array (FPGA) to accomplish a high frame rate of 60 fps with minimum processing delay. Along with this, a viewer has also been developed to display and control the image-processing pipeline. The control and data transfer are done by a USB 3.0 end point in the computer. The full developed system achieves real-time processing of the image and fits in a Xilinx Spartan-6LX150 FPGA.info:eu-repo/semantics/publishedVersio

Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: an in vitro study

A commonly applied strategy in the field of tissue engineering (TE) is the use of temporary three-dimensional scaffolds for supporting and guiding tissue formation in various in vitro strategies and in vivo regeneration approaches. The interactions of these scaffolds with highly sensitive bioentities such as living cells and tissues primarily occur through the material surface. Hence, surface chemistry and topological features have principal roles in coordinating biological events at the molecular, cellular and tissue levels on timescales ranging from seconds to weeks. However, tailoring the surface properties of scaffolds with a complex shape and architecture remains a challenge in materials science. Commonly applied wet chemical treatments often involve the use of toxic solvents whose oddments in the construct could be fatal in the subsequent application. Aiming to shorten the culture time in vitro (i.e. prior the implantation of the construct), in this work we propose a modification of previously described bone TE scaffolds made from a blend of starch with polycaprolactone (SPCL). The modification method involves surface grafting of sulfonic or phosphonic groups via plasma-induced polymerization of vinyl sulfonic and vinyl phosphonic acid, respectively. We demonstrate herein that the presence of these anionic functional groups can modulate cell adhesion mediated through the adsorbed proteins (from the culture medium). Under the conditions studied, both vitronectin adsorption and osteoblast proliferation and viability increased in the order SPCL!sulfonic-grafted SPCL < phosphonic-grafted SPCL. The results revealed that plasmainduced polymerization is an excellent alternative route, when compared to the commonly used wet chemical treatments, for the surface functionalization of biodevices with complex shape and porosity.The authors acknowledge funding from EU Marie Curie Actions, Alea Jacta Est (MEST-CT-2004-008104) and the Portuguese Foundation for Science and Technology (FCT) (SFRH/BPD/34545/2007). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283). The authors also acknowledge Dr. M.I. Santos and C. Serra for their assistance on the CLSM and XPS experiments

Impact of Euro-Atlantic blocking patterns in Iberia precipitation using a novel high resolution dataset

In this work we reassess the impacts of blocking patterns on precipitation regimes in the Iberian Peninsula, distinguishing between north Atlantic and European blocking. For this we take full advantage of the recently developed high-resolution datasets for the Iberian countries. Precipitation anomalies during blocking events obtained with this dataset allow a much finer regional characterization of the impacts in both average and extreme daily precipitation, particularly when compared to widely used low-resolution reanalysis datasets. Blocked patterns induce a negative-positive dipole of precipitation anomalies from northwest to southeast Iberia. Increases are widespread during Atlantic blocks and pronounced in southern and eastern areas of Iberia, while during European blocks they are more spatially restricted, with increases above 50 % in coastal Mediterranean areas, which represents a considerable fraction of the annual precipitation. Blocking impacts in precipitation are nearly opposite to those found during strong zonal flow situations, but there are also some asymmetries in the precipitation responses. A significant increase in cyclones and cut-off lows frequency southwards of blocking structures is related to precipitation excesses over southern and eastern areas, where dynamical factors and local processes play a crucial role. On the contrary, precipitation deficits in northwest Iberia during blocking episodes are better explained by a reduction in north Atlantic frontal activity and simultaneous decreases in large-scale moisture advection towards northern Iberia. We show that these anomalies during blocking result from changes in precipitation amount rather than from increases in rainy days, pointing to more extreme rainfall regimes, particularly in southeastern Iberia. Finally, an Extreme Value Analysis was performed, fitting Generalized Pareto Distributions to precipitation extremes. Results show that the different extreme precipitation regimes of northwest and Mediterranean regions are partially determined by opposite anomalies of the zonal flow. Thus, heavy precipitation events in Mediterranean areas are usually short-lived and frequently associated with blocking conditions, while in northwest Iberia the total accumulations during rainfall episodes are more important for triggering extreme events and they are mainly related to strong westerly flows.Peer reviewe