Differential expression of placental glucocorticoid receptors and growth arrest-specific transcript 5 in term and preterm pregnancies: evidence for involvement of maternal stress.

This article has been made available through the Brunel Open Access Publishing Fund.Pregnancy-specific stress predicts birth outcomes. We hypothesized that there is a maternal stress-GR interaction that can influence fetal birth weight. This study examined the relationship between mothers' stress and attitude towards their pregnancies, placental glucocorticoid receptors (GRs) and growth arrest-specific transcript 5 (GAS5) expression, and the status of GR polymorphism, with their infants' birth weights. GAS5 and GR α were the predominant transcripts in both term and preterm placentas, with GAS5 being primarily localized in the syncytiotrophoblasts. In an attempt to mimic moderate and high stress environment in vitro, BeWo and JEG-3 cytotrophoblast cell lines were treated with 10 nM-1000 nM cortisol. Only expression of GAS5 was significantly upregulated by cortisol in all treatments compared with basal levels, but none of the GRs changed expression significantly. In an attempt to assess a stress versus gene interaction, we studied four GR polymorphisms. In the homozygous group for Tth111I polymorphism, mothers with negative attitudes towards the pregnancy gave birth to infants with significantly lower birth weights compared to women with positive/neutral attitudes. None of the GR splice variants were associated with maternal stress. However, placental GAS5 levels were inversely correlated with maternal stress. This study points towards a potential gene-environment interaction that could be of predictive value for fetal weight.Brunel Open Access Publishing Fun

GEOMORPHIC CONSTRAINS ON THE EVOLUTION OF THE AGGITIS RIVER BASIN NORTHERN GREECE (A PRELIMINARY REPORT)

Στην παρούσα εργασία αναλύουμε την γεωμορφολογική εξέλιξη της κοιλάδας του Αγγίτη ποταμού και παρουσιάζουμε τον συσχετισμό των μορφολογικών χαρακτηριστικών από το σπήλαιο του Μααρά (Σπήλαιο πηγών Αγγίτη) με τις διάφορες γεωμορφές στην κοιλάδα του ποταμού. Παράλληλα, επιχειρούμε να θέσουμε ένα γενικό χρονολογικό πλαίσιο για την εξέλιξη της κοιλάδας. Για τον σκοπό αυτό μελετήσαμε το σπήλαιο και τις γεωμορφές στο εσωτερικό του ενώ παράλληλα μελετήθηκε και η επιφανειακή μορφολογία. Η τρισδιάστατη χαρτογράφηση του σπηλαίου έδειξε ότι η οροφή του σπηλαίου έχει κυματοειδές σχήμα ενώ το δάπεδό του παρουσιάζει μικρή κλίση και είναι καλυμμένο με κλαστικές αποθέσεις μεγάλου πάχους. Η γεωμορφολογική χαρτογράφηση έδειξε πως στο νότιο τμήμα της κοιλάδας υπάρχουν δύο windgaps. Αξιολογώντας τα αποτελέσματα καταλήγουμε στο συμπέρασμα ότι τέσσερα εξελεκτικά στάδια διαμόρφωσαν την κοιλάδα του Αγγίτη ποταμού κατά την περίοδο από το Νεογενές ως το Τεταρτογενές.In this paper we discuss the landscape evolution of the Aggitis River basin by correlating the morphological characteristics of the Maaras Cave (Aggitis River spring) with the main geomorphological features of the Aggitis fluvial valley. We combine the various morphological features that are hidden inside the Maaras Cave with the surface geomorphology of the river valley in order to trace the imprint of the different evolutionary stages on the landscape. Also, we provide a relative chronological framework for the evolution of the area. The 3D survey of the Maaras Cave shows that the roof of the cave is looping-like shaped in contrast to the floor of the cave that shows low slopes and holds thick clastic sediment deposits. Furthermore, the geomorphological mapping of the Aggitis River valley shows two prominent windgaps at the southern part of the basin that formed as the result of river capture. Our results suggest that the Aggitis River basin suffered four major evolutionary stages from the Neogene until the Quaternary

Measuring Black Hole Formations by Entanglement Entropy via Coarse-Graining

We argue that the entanglement entropy offers us a useful coarse-grained entropy in time-dependent AdS/CFT. We show that the total von-Neumann entropy remains vanishing even when a black hole is created in a gravity dual, being consistent with the fact that its corresponding CFT is described by a time-dependent pure state. We analytically calculate the time evolution of entanglement entropy for a free Dirac fermion on a circle following a quantum quench. This is interpreted as a toy holographic dual of black hole creations and annihilations. It is manifestly free from the black hole information problem.Comment: 25 pages, Latex, 8 figure

Bose--Einstein Condensation in the Large Deviations Regime with Applications to Information System Models

We study the large deviations behavior of systems that admit a certain form of a product distribution, which is frequently encountered both in Physics and in various information system models. First, to fix ideas, we demonstrate a simple calculation of the large deviations rate function for a single constraint (event). Under certain conditions, the behavior of this function is shown to exhibit an analogue of Bose--Einstein condensation (BEC). More interestingly, we also study the large deviations rate function associated with two constraints (and the extension to any number of constraints is conceptually straightforward). The phase diagram of this rate function is shown to exhibit as many as seven phases, and it suggests a two--dimensional generalization of the notion of BEC (or more generally, a multi--dimensional BEC). While the results are illustrated for a simple model, the underlying principles are actually rather general. We also discuss several applications and implications pertaining to information system models

On Field Theory Thermalization from Gravitational Collapse

Motivated by its field theory interpretation, we study gravitational collapse of a minimally coupled massless scalar field in Einstein gravity with a negative cosmological constant. After demonstrating the accuracy of the numerical algorithm for the questions we are interested in, we investigate various aspects of the apparent horizon formation. In particular, we study the time and radius of the apparent horizon formed as functions of the initial Gaussian profile for the scalar field. We comment on several aspects of the dual field theory picture.Comment: 31 pages, 17 figures; V2 Some figures corrected, minor revision. arXiv admin note: substantial text overlap with arXiv:1106.233

IoTNetSim:A Modelling and Simulation Platform for End-to-End IoT Services and Networking

Internet-of-Things (IoT) systems are becoming increasingly complex, heterogeneous and pervasive, integrating a variety of physical devices and virtual services that are spread across architecture layers (cloud, fog, edge) using different connection types. As such, research and design of such systems have proven to be challenging. Despite the influx in IoT research and the significant benefits of simulation-based approaches in supporting research, there is a general lack of appropriate modelling and simulation platforms to create a detailed representation of end-to-end IoT services, i.e. from the underlying IoT nodes to the application layer in the cloud along with the underlying networking infrastructure. To aid researchers and practitioners in overcoming these challenges, we propose IoTNetSim, a novel self-contained extendable platform for modelling and simulation of end-to-end IoT services. The platform supports modelling heterogeneous IoT nodes (sensors, actuators, gateways, etc.) with their fine-grained details (mobility, energy profile, etc.), as well as different models of application logic and network connectivity. The proposed work is distinct from the current literature, being an all-in-one tool for end-to-end IoT services with a multi-layered architecture that allows modelling IoT systems with different structures. We experimentally validate and evaluate our IoTNetSim implementation using two very large-scale real-world cases from the natural environment and disaster monitoring IoT domains

Entanglement Hamiltonians in 1D free lattice models after a global quantum quench

We study the temporal evolution of the entanglement Hamiltonian of an interval after a global quantum quench in free lattice models in one spatial dimension. In a harmonic chain we explore a quench of the frequency parameter. In a chain of free fermions at half filling we consider the evolution of the ground state of a fully dimerised chain through the homogeneous Hamiltonian. We focus on critical evolution Hamiltonians. The temporal evolutions of the gaps in the entanglement spectrum are analysed. The entanglement Hamiltonians in these models are characterised by matrices that provide also contours for the entanglement entropies. The temporal evolution of these contours for the entanglement entropy is studied, also by employing existing conformal field theory results for the semi-infinite line and the quasi-particle picture for the global quench