First evidence for spectral state transitions in the ESO243-49 hyper luminous X-ray source HLX-1

The brightest Ultra-Luminous X-ray source (ULX), ESO 243-49 HLX-1, with a 0.2 - 10 keV X-ray luminosity of up to 10^42 erg s^-1, provides the strongest evidence to date for the existence of intermediate mass black holes. Although small scale X-ray spectral variability has already been demonstrated, we have initiated a monitoring campaign with the X-ray Telescope onboard the Swift satellite to search for luminosity-related spectral changes and to compare its behavior with the better studied stellar mass black holes. In this paper, we report a drop in the XRT count rate by a factor of ~8 which occurred simultaneously with a hardening of the X-ray spectrum. A second observation found that the source had re-brightened by a factor of ~21 which occurred simultaneously with a softening of the X-ray spectrum. This may be the first evidence for a transition between the low/hard and high/soft states.Comment: Accepted by ApJ Letter, 2 figure

Tear proteomic profiling with MALDI-TOF mass spectrometry coupled with magnetic-beads HIC-18 separation as a diagnostic tools in blepharitis disease

Comunicaciones a congreso

Album descriptivo del Ejército y de la Armada

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-2013Las h. de lám.: " dibujos de Soria Santa Cruz y Teo Rufflé, cromolitº.

Discovery of an optical counterpart to the hyperluminous X-ray source in ESO 243-49

The existence of black holes of masses ~ 10^2-10^5 Msun has important implications for the formation and evolution of star clusters and supermassive black holes. One of the strongest candidates to date is the hyperluminous X-ray source HLX1, possibly located in the S0-a galaxy ESO243-49, but the lack of an identifiable optical counterpart had hampered its interpretation. Using the Magellan telescope, we have discovered an unresolved optical source with R = (23.80 +/- 0.25) mag and V = (24.5 +/- 0.3) mag within HLX1's positional error circle. This implies an average X-ray/optical flux ratio ~ 500. Taking the same distance as ESO243-49, we obtain an intrinsic brightness M_R = (-11.0 +/- 0.3) mag, comparable to that of a massive globular cluster. Alternatively, the optical source is consistent with a main-sequence M star in the Galactic halo (for example an M4.4 star at ~ 2.5 kpc). We also examined the properties of ESO243-49 by combining Swift/UVOT observations with stellar population modelling. We found that the overall emission is dominated by a ~5 Gyr old stellar population, but the UV emission at ~2000 Ang is mostly due to ongoing star-formation at a rate of ~ 0.03 Msun/yr. The UV emission is more intense (at least a 9-sigma enhancement above the mean) North East of the nucleus, in the same quadrant as HLX1. With the combined optical and X-ray measurements, we put constraints on the nature of HLX1. We rule out a foreground star and a background AGN. Two alternative scenarios are still viable. HLX1 could be an accreting intermediate-mass black hole in a star cluster, which may itself be the stripped nucleus of a dwarf galaxy that passed through ESO243-49, an event which might have caused the current episode of star formation. Or, it could be a neutron star in the Galactic halo, accreting from an M4-M5 donor star.Comment: 7 pages, accepted by MNRAS. Several improvements from Oct 7 version: stronger evidence of the optical counterpart; more accurate estimate of its brightness (a factor of 2 brighter than previously estimated); use of a larger set of Swift/UVOT data to measure the recent star formation rate in ESO243-49; improved discussion and comparison of the competing scenario

Protease and hemicellulase assisted extraction of dietary fiber from wastes of Cynara cardunculus

6057-6075The action of protease and hemicellulase for the extraction of fractions enriched in soluble fiber from bracts and stems of Cynara cardunculus was evaluated. Using a two-factor simplex design comprising protease amounts of 0-200 ?L and hemicellulase amounts of 0-200 mg for 5 g of material, we explored the effect of a 5 h enzymatic treatment at 40 °C on the chemical composition and yield of the fractions isolated. The fractions contained inulin and pectin. In general, the protein, inulin, and polyphenol contents and also the yields were higher for fractions obtained from stems. The most marked effects were observed when enzymes were used at higher concentrations, especially for hemicellulase. The inclusion of a pre-heating step increased the yield and the inulin content for fractions isolated from bracts and stems and decreased the protein and polyphenol contents, and the galacturonic acid for bracts. These fractions, in general, contained the polyphenolic compounds monocaffeoylquinic acid, apigenin, and pinoresinol

An Investigation of Be/X-ray Pulsars with OGLE-III Data

We have studied five seasons of OGLE-III data for eight SMC Be/X-ray pulsars for which no other survey data were available. We have determined orbital periods for four of these binary systems, one of which also shows nonradial pulsations. Optical identification of SMC X-2 is reconsidered, but no periods were found for either of the two possible candidates

Advertising Liking Recognition Technique Applied to Neuromarketing by Using Low-Cost EEG Headset

In this paper a new neuroscience technique is applied into Marketing, which is becoming commonly known as the field of Neuromarketing. The aim of this paper is to recognize how brain responds during the visualization of short advertising movies. Using low cost electroencephalography (EEG), brain regions used during the presentation have been studied. We may wonder about how useful it is to use neuroscience knowledge in marketing, what can neuroscience add to marketing, or why use this specific technique. By using discrete techniques over EEG frequency bands of a generated labeled dataset, C4.5 and ANN learning methods have been applied to obtain the score assigned to each ads by the user. This techniques allows to reach more than 82% of accuracy, which is an excellent result taking into account the kind of low-cost EEG sensors used.Ministerio de Economía y Competitividad TIN2013-46801- C4-1-rJunta de Andalucía TIC-805

Increased expression of cystine/glutamate antiporter in multiple sclerosis

<p>Abstract</p> <p>Background</p> <p>Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which may be related to the pathophysiology of this disease. In addition to glutamate transporters, levels of extracellular glutamate are controlled by cystine/glutamate antiporter x_c^-, an exchanger that provides intracellular cystine for production of glutathione, the major cellular antioxidant. The objective of this study was to analyze the role of the system x_c^-in glutamate homeostasis alterations in MS pathology.</p> <p>Methods</p> <p>Primary cultures of human monocytes and the cell line U-937 were used to investigate the mechanism of glutamate release. Expression of cystine glutamate exchanger (xCT) was quantified by quantitative PCR, Western blot, flow cytometry and immunohistochemistry in monocytes in vitro, in animals with experimental autoimmune encephalomyelitis (EAE), the animal model of MS, and in samples of MS patients.</p> <p>Results and discussion</p> <p>We show here that human activated monocytes release glutamate through cystine/glutamate antiporter x_c^-and that the expression of the catalytic subunit xCT is upregulated as a consequence of monocyte activation. In addition, xCT expression is also increased in EAE and in the disease proper. In the later, high expression of xCT occurs both in the central nervous system (CNS) and in peripheral blood cells. In particular, cells from monocyte-macrophage-microglia lineage have higher xCT expression in MS and in EAE, indicating that immune activation upregulates xCT levels, which may result in higher glutamate release and contribution to excitotoxic damage to oligodendrocytes.</p> <p>Conclusions</p> <p>Together, these results reveal that increased expression of the cystine/glutamate antiporter system x_c^-in MS provides a link between inflammation and excitotoxicity in demyelinating diseases.</p