1,884 research outputs found
Analysis of the function of Drop out, the single homologue of human MAST kinases, in <i>Drosophila</i> cellularisation
A Histologic Evaluation of One Versus Two Intracanal Preparation Appointments with Residual Sodium Hypochlorite
User interface design for mobile-based sexual health interventions for young people: Design recommendations from a qualitative study on an online Chlamydia clinical care pathway
Background: The increasing pervasiveness of mobile technologies has given potential to transform healthcare by facilitating clinical management using software applications. These technologies may provide valuable tools in sexual health care and potentially overcome existing practical and cultural barriers to routine testing for sexually transmitted infections. In order to inform the design of a mobile health application for STIs that supports self-testing and self-management by linking diagnosis with online care pathways, we aimed to identify the dimensions and range of preferences for user interface design features among young people. Methods: Nine focus group discussions were conducted (n=49) with two age-stratified samples (16 to 18 and 19 to 24 year olds) of young people from Further Education colleges and Higher Education establishments. Discussions explored young people's views with regard to: the software interface; the presentation of information; and the ordering of interaction steps. Discussions were audio recorded and transcribed verbatim. Interview transcripts were analysed using thematic analysis. Results: Four over-arching themes emerged: privacy and security; credibility; user journey support; and the task-technology-context fit. From these themes, 20 user interface design recommendations for mobile health applications are proposed. For participants, although privacy was a major concern, security was not perceived as a major potential barrier as participants were generally unaware of potential security threats and inherently trusted new technology. Customisation also emerged as a key design preference to increase attractiveness and acceptability. Conclusions: Considerable effort should be focused on designing healthcare applications from the patient's perspective to maximise acceptability. The design recommendations proposed in this paper provide a valuable point of reference for the health design community to inform development of mobile-based health interventions for the diagnosis and treatment of a number of other conditions for this target group, while stimulating conversation across multidisciplinary communities
Oral human papillomavirus (HPV) infection in men who have sex with men: prevalence and lack of anogenital concordance.
To estimate the prevalence of oral detectable human papillomavirus (HPV) DNA in HIV-negative men who have sex with men (MSM) attending a sexual health clinic in London and concordance with anogenital HPV infection. Such data are important to improve our understanding of the epidemiology of oral HPV and the potential use of vaccines to prevent oropharyngeal cancers
The development of a scale for measuring voluntary simplistic clothing consumption in the South African emerging market context
This study\u27s purpose was to develop a scale to enable investigation of voluntary simplistic clothing consumption in the South African emerging market context. Initial scale generation, purification, and subsequent validation procedures were followed. A pool of 22 items was included in a structured, self-administered questionnaire that was distributed among respondents from various gender, ethnic and age groups in Gauteng. The resulting data was split randomly into two data sets with one half used for scale purification (n = 501) and the other half for scale validation (n = 501). Purification procedures involved scrutiny of corrected item-total correlations and subsequent exploratory factor analysis (EFA). Further confirmatory factor analysis (CFA) produced a three-factor solution based on 12 items that parsimoniously represented three dimensions of voluntary simplistic consumption practices namely, supporting local, ethical clothing brands, preferring unique, handcrafted clothing and reducing clothing consumption. This factor solution was re-confirmed through subsequent CFA procedures
Can remote STI/HIV testing and eClinical Care be compatible with robust public health surveillance?
In this paper we outline the current data capture systems for human immunodeficiency virus (HIV) and sexually transmitted infection (STI) surveillance used by Public Health England (PHE), and how these will be affected by the introduction of novel testing platforms and changing patient pathways. We outline the Chlamydia Online Clinical Care Pathway (COCCP), developed as part of the Electronic Self-Testing for Sexually Transmitted Infections (eSTI(2)) Consortium, which ensures that surveillance data continue to be routinely collected and transmitted to PHE. We conclude that both novel diagnostic testing platforms and established data capture systems must be adaptable to ensure continued robust public health surveillance
Ankle foot orthoses for young children with cerebral palsy: a scoping review.
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordAim: To describe research on outcomes associated with early Ankle Foot Orthosis (AFO) use, AFO use patterns, and parent and clinician perspectives on AFO use among young children with cerebral palsy. Method: Arksey and O'Malley's five-stage method was used to conduct a scoping review. MEDLINE (Ovid), PubMed, CINAHL, Cochrane Database of Systematic Reviews, EMBASE, PEDro, Web of Science and Scopus were searched for studies evaluating AFO use with children under the age of six years. Descriptive information was extracted and outcomes categorized according to the International Classification of Functioning, Disability and Health (ICF). Quality assessments were conducted to evaluate methodological rigor. Results: Nineteen articles were included in the review; 14 focused on body functions and structures, seven on activity level outcomes and no studies addressed participation outcomes. Evaluations of the effects of AFOs on gross motor skills other than gait were limited. Overall, the body of evidence is comprised of methodologically weak studies with common threats to validity including inadequate descriptions of study protocols, AFO construction, and comparison interventions. Conclusion: Research evaluating the effects of AFOs on age-appropriate, functional outcomes including transitional movements, floor mobility and participation in early childhood settings is needed to inform practice regarding early orthotic prescription. Implications for rehabilitation Lack of rigorous evidence about the effects of AFOs in young children limits the ability of research to guide practice in pediatric rehabilitation. More rigorous research that evaluates a broader range of age-appropriate outcomes, including those focused on participation in meaningful activities, could further inform clinical practice. While clinicians often discuss expectations and goals with individual families, qualitative research that provides more insight into the experiences of families could guide AFO prescription and monitoring practices
The prevalence of, and factors associated with, paying for sex among men resident in Britain: findings from the third national survey of sexual attitudes and lifestyles (Natsal-3)
Objectives Men who pay for sex (MPS) are considered a bridging population for sexually transmitted infections (STI). However, the extent, characteristics and role of MPS in transmission is poorly understood. We investigate these questions using data from Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).
Methods We performed complex survey analyses of data from 6293 men aged 16–74 years resident in Britain who completed Natsal-3, a probability sample survey undertaken during 2010–2012, using computer-assisted personal interviewing and computer-assisted self-interview.
Results 11.0% (95% CI10.1% to 11.9%) of all men reported ever paying for sex. Among MPS, 18.4% (95% CI 18.2% to 18.7%) of their lifetime sexual partners were paid. 3.6% (95% CI 3.1% to 4.2%) of men had paid for sex in the past 5 years. Partners of MPS constitute 14.7% of all reported partners and MPS report 15.6% of all reported STI diagnoses in the past 5 years. Paying for sex in the past 5 years was strongly associated with reporting larger numbers of sexual partners (adjusted OR, AOR for 5+ partners, past 5 years, 31.50, 95% CI 18.69 to 53.09). After adjusting for partner numbers, paying for sex remained strongly associated with reporting new foreign partners outside the UK (AOR 7.96; 95% CI 4.97 to 12.73) and STI diagnosis/es (AOR 2.34; 95% CI 1.44 to 3.81), all in the past 5 years. Among men ever paying for sex, 62.6% (95% CI 58.3% to 66.8%) reported paying for sex outside the UK, most often in Europe and Asia.
Conclusions MPS in Britain remain at greater risk of STI acquisition and onward transmission than men who do not. They report high numbers of partners, but the minority are paid partners. They are an important core group in STI transmission
Input-Output Fase II. Verificatie Input-Output fase I - Invloed vochtgehalte op afbraak organische stof - Data van 4 teeltbedrijven
In het verleden zijn diverse studies gedaan aan klimaat, substraat en het uiteindelijke product, de champignon. Hierdoor zijn kwaliteit en opbrengt sterk verbeterd. Toch is er onvoldoende kennis over wat precies de opbrengst en de kwaliteit van het product bepaalt. Leemte in deze kennis verhindert dat er doelgericht een grote stap vooruit gemaakt kan worden in de ontwikkeling van nieuwe productiesystemen. Het input-output project heeft als doel het huidige systeem beter te begrijpen, bloot te leggen waar de grenzen van het systeem liggen en waar kansen liggen voor verbetering op korte termijn. Gezien het aandeel van de kosten van het substraat in de teelt (ca. 40%) en de oplopende kosten van de grondstoffen is het gewenst dat dit substraat efficiënter benut wordt. Daarmee is, bij gelijkblijvende productiehoeveelheid, ook minder transport en minder reststromen gemoeid en wordt het systeem duurzamer. In dit vervolgproject is aangetoond dat metingen in de eerste fase goed reproduceerbaar zijn en vergelijkbaar met snij- en plukbedrijven. Tevens is aangetoond dat de verminderde afbraak in de onderste laag compost gerelateerd is aan een te hoog vochtgehalte van deze laag. Specifieke bijvoedmiddelen en aanpassingen aan het teeltsysteem kunnen in vervolgexperimenten aantonen hoe een rendementsverbetering in de praktijk is te realiseren
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