Ergonomic Risk Assessment for Forced Posture

Applying the ergonomic method "rapid assessment of the whole body" (REBA), a way of evaluation and diagnosis of the jobs immersed within the direction of Human Talent of the Provincial Government of Manabí (GPM) is demonstrated. To the prevention of future diseases by studying techniques that can improve the health of the personnel involved. A diagnosis of the risk factors present in the workplace was carried out. The field evaluation was carried out and the descriptive procedure was applied by collecting data from a population in association with the following techniques: observation, survey, matrix, As a result, a rest break system should be implemented so that people can recover their energies in order to improve their work performance and that they develop training, talks, and workshops that help to improve knowledge about ergonomics and their risk factors

A call for clinical trial globalization in Alzheimer\u27s disease and related dementia

BACKGROUND: The burden of Alzheimer\u27s disease and related dementia (ADRD) is projected to disproportionally impact low-middle-income countries (LMICs). However, there is a systematic under-representation of LMICs in ADRD clinical trial platforms. METHODS: We aimed to determine the global distribution of ADRD clinical trials and identify existing barriers for conducting clinical trials in LMICs. Primary data sources to identify trial distribution in LMICs included ClinicalTrials.gov and the International Trials Registry Platform. An additional systematic review and expert consensus interviews were conducted to identify barriers for conducting clinical trials in LMICs. FINDINGS: Among 1237 disease-modifying therapies tested in ADRD clinical trials, only 11.6% have been or are conducted in emerging economies (upper-middle income [9.6%] and low-middle income [2.0%]). We identified several limitations for trial implementation including a lack of financial resources, low industry presence, regulatory obstacles, and operational barriers INTERPRETATION: Although LMICs bear the greatest burden of ADRD globally, substantial development of clinical trial platforms to address this inequity and health disparity is lacking

Exploration for Triatoma virus (TrV) infection in laboratory-reared triatomines of Latin America: a collaborative study

Triatoma virus (TrV) is a small, non-enveloped virus that has a +ssRNA genome and is currently classified under the Cripavirus genus of the Dicistroviridae family. TrV infects haematophagous triatomine insects (Hemiptera: Reduviidae), which are vectors of American Trypanosomiasis (Chagas disease). TrV can be transmitted through the horizontal fecal-oral route, and its infection causes either deleterious sublethal effects or even death of laboratory insect colonies. Various species of triatomines from different regions of Latin America are currently being reared in research laboratories, with little or no awareness of the presence of TrV; therefore, any biological conclusion drawn from experiments on insects infected with this virus is inherently affected by the side effects of its infection. In this study, we developed a mathematical model to estimate the sample size required for detecting a TrV infection. We applied this model to screen the infection in feces of triatomines belonging to insectaries from 13 Latin American countries, carrying out the identification of TrV by using reverse transcriptase PCR. TrV was detected in samples coming from Argentina, which is the country where several years ago the virus was first isolated from Triatoma infestans (Hemiptera: Reduviidae). Interestingly, several colonies from Brazil were also found infected with the virus. This positive result widens the TrV?s host range to a total of 14 triatomine species. Our findings suggest that many triatomine species distributed over a large region of South America may be naturally infected with TrV.Fil: Marti, Gerardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Estudios Parasitologicos y de Vectores. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Centro de Estudios Parasitologicos y de Vectores; ArgentinaFil: Echeverria, Maria Gabriela. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Susevich, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Estudios Parasitologicos y de Vectores. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Centro de Estudios Parasitologicos y de Vectores; ArgentinaFil: Ceccarelli, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Estudios Parasitologicos y de Vectores. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Centro de Estudios Parasitologicos y de Vectores; ArgentinaFil: Balsalobre, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Estudios Parasitologicos y de Vectores. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Centro de Estudios Parasitologicos y de Vectores; ArgentinaFil: Canale, Delmi Margarita. Centro de Referencia de Vectores, Coordinación Nacional de Control de Vectores, Pabellón Rawson-Hospital Colonia; ArgentinaFil: Stariolo, Raúl Luis. Centro de Referencia de Vectores, Coordinación Nacional de Control de Vectores, Pabellón Rawson-Hospital Colonia; ArgentinaFil: Guérin, Diego M. A.. Universidad del País Vasco; España. Consejo Superior de Investigaciones Cientificas; España. Universidad Politécnica de Valencia; EspañaFil: González Cifuentes, Nadia L.. Universidad de Los Andes; ColombiaFil: Guhl, Felipe. Universidad de Los Andes; ColombiaFil: Bacigalupo, Antonella. Universidad de Chile; ChileFil: Cattan, Pedro E.. Universidad de Chile; ChileFil: Garcıa, Alejandro. Secretaria Regional Ministerial de Salud de Coquimbo; ChileFil: Villacis, Anita G.. Pontificia Universidad Catolica del Ecuador; EcuadorFil: Grijalva, Mario J.. Pontificia Universidad Catolica del Ecuador; Ecuador. Ohio University; Estados UnidosFil: Solorzano, Elizabeth. Universidad de San Carlos; GuatemalaFil: Monroy, Carlota. Universidad de San Carlos; GuatemalaFil: Espinoza Blanco, Yrma. Universidad Nacional Mayor de San Marcos; PerúFil: Cordova Benzaquen, Eleazar. Universidad Nacional San Agustín de Arequipa; PerúFil: Ruelas llerena, Nancy. Universidad Nacional San Agustín de Arequipa; PerúFil: Guzmán loayza, Miriam. Dirección Regional de Salud Moquegua; PerúFil: Caceres, Abraham G.. Universidad Nacional Mayor de San Marcos; PerúFil: Vences Blanco, Mauro O.. Universidad Nacional Autónoma de México; MéxicoFil: Salazar Schettino, Paz María. Universidad Nacional Autónoma de México; MéxicoFil: Martínez Martínez, Ignacio. Universidad Nacional Autónoma de México; MéxicoFil: Espinoza Gutiérrez, Bertha. Universidad Nacional Autónoma de México; MéxicoFil: Mojoli, Andrés. Centro para el Desarrollo de la Investigación Científica. Asunción; ParaguayFil: Rojas de Arias, Antonieta. Centro para el Desarrollo de la Investigación Científica. Asunción; ParaguayFil: Feliciangeli, M. Dora. Universidad de Carabobo Maracay; VenezuelaFil: Rivera Mendoza, Pedro. Fundación para el Desarrollo; NicaraguaFil: Rozas Dennis, Gabriela Susana. Universidad Nacional del Sur; ArgentinaFil: Sánchez Eugenia, Rubén. Unidad de Biofísica; EspañaFil: Aguirre, Jon. Unidad de Biofísica; España. Fundación Biofísica Bizkaia; EspañaFil: Viguera, Ana R.. Unidad de Biofísica; EspañaFil: Hernádez Suárez, Carlos M.. Universidad de Colima; México. Unidad Monterrey; MéxicoFil: Vilchez, Susana. Universidad de Granada; EspañaFil: Osuna, Antonio. Universidad de Granada; EspañaFil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de la Rioja. - Secretaria de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; ArgentinaFil: Mougabure Cueto, Gastón Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; ArgentinaFil: Esteban, Lidia. Universidad Industrial Santander; ColombiaFil: Angulo, Vıctor M.. Universidad Industrial Santander; ColombiaFil: Querido, Jailson F. B. Unidad de Biofísica; España. Fundación Biofísica Bizkaia; España. Universidad Nova de Lisboa; PortugalFil: Silva, Marcelo S.. Universidad Nova de Lisboa; PortugalFil: Marques, Tatiane. Universidade Federal do Triangulo Mineiro; BrasilFil: Anhe, Ana Carolina B. M.. Universidade Federal do Triangulo Mineiro; BrasilFil: Gomez Hernandez, Cesar. Universidade Federal do Triangulo Mineiro; BrasilFil: Ramirez, Luis E.. Universidade Federal do Triangulo Mineiro; BrasilFil: Rabinovich, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Estudios Parasitologicos y de Vectores. Universidad Nacional de la Plata. Facultad de Cs.naturales y Museo. Centro de Estudios Parasitologicos y de Vectores; ArgentinaFil: Diotaiuti, Liléia. Centro de Pesquisas Rene Rachou-FIOCRUZ; BrasilFil: Guerin Aguilar , Diego Marcelo. Universidad del País Vasco; España. Unidad de Biofísica; España. Fundación Biofísica Bizkaia; Españ

A multinational Delphi consensus to end the COVID-19 public health threat

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches1, while maintaining proven prevention measures using a vaccines-plus approach2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end

A Systematic Framework to Rapidly Obtain Data on Patients with Cancer and COVID-19: CCC19 Governance, Protocol, and Quality Assurance

When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 institutions with >400 collaborators. More than 5,000 cases with complete baseline data have been accrued. Future directions include increased electronic health record integration for direct data ingestion, expansion to additional domestic and international sites, more intentional patient involvement, and granular analyses of still-unanswered questions related to cancer subtypes and treatments. When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 institutions with >400 collaborators. More than 5,000 cases with complete baseline data have been accrued. Future directions include increased electronic health record integration for direct data ingestion, expansion to additional domestic and international sites, more intentional patient involvement, and granular analyses of still-unanswered questions related to cancer subtypes and treatments

Neotropical freshwater fisheries : A dataset of occurrence and abundance of freshwater fishes in the Neotropics

The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large-scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distribution records, with unique georeferenced coordinates, for the 4225 species, represented by occurrence and abundance data. The number of species for the most numerous orders are as follows: Characiformes (1289), Siluriformes (1384), Cichliformes (354), Cyprinodontiformes (245), and Gymnotiformes (135). The most recorded species was the characid Astyanax fasciatus (4696 records). We registered 116,802 distribution records for native species, compared to 1802 distribution records for nonnative species. The main aim of the NEOTROPICAL FRESHWATER FISHES data set was to make these occurrence and abundance data accessible for international researchers to develop ecological and macroecological studies, from local to regional scales, with focal fish species, families, or orders. We anticipate that the NEOTROPICAL FRESHWATER FISHES data set will be valuable for studies on a wide range of ecological processes, such as trophic cascades, fishery pressure, the effects of habitat loss and fragmentation, and the impacts of species invasion and climate change. There are no copyright restrictions on the data, and please cite this data paper when using the data in publications