21 research outputs found

    The contribution of MTHFR C677T polymorphism to peripheral artery disease in diabetic patients

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    The aim of this study was to investigate the association between functional polymorphism C677T (rs1801133) of methylenetetrahydrofolate reductase (MTHFR) gene for and risk of peripheral artery disease in diabetes patient

    The development mechanism of financial resources of the housing mortgage lending in Russia

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    The urgency of the analyzed issue is due to the priority of state issues of providing the population with affordable and comfortable housing. The purpose of research is to develop the main provisions of the development mechanism of financial resources of the housing mortgage lending and to develop practical recommendations for its implementation. The leading approach to research this issue is a systematic approach, which used such scientific methods as analysis and synthesis, economic and mathematical and statistical methods, logic, and dialectic methods. Key findings of research are to develop the functional model of the development mechanism of financial resources of the housing mortgage lending; to clarify the understanding of mortgage and housing mortgage lending. The article also shows the scheme of public-private partnerships in order to enhance the formation of financial resources for the construction of affordable housing for the population. The contents of the article may be used in the practice of commercial banks in attracting financial resources and regional authorities in order to improve the housing supply. Β© 2016 Savinova et al

    Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study

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    Glutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of glutathione is associated with an increased host susceptibility to oxidative stress, a pathological condition implicated in the development and progression of cancer. The catalytic subunit of glutamate-cysteine ligase (GCLC) is an enzyme responsible for the initial and rate-limiting step of glutathione biosynthesi

    ВлияниС ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Pro198Leu Π³Π΅Π½Π° глутатионпСроксидазы 1-Π³ΠΎ Ρ‚ΠΈΠΏΠ° Π½Π° риск развития аллСргичСской Π±Ρ€ΠΎΠ½Ρ…ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ астмы Ρƒ ΠΌΡƒΠΆΡ‡ΠΈΠ½

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    The purpose of our pilot study was to investigate the association between Pro198Leu polymorphism in the glutathione peroxidase-1 gene (GPX1) and susceptibility to atopic and non-atopic asthma in Russian residents of the Central region of Russia. Blood samples from 213 asthmatics and 205 healthy controls matched on gender and age were analyzed for P198L polymorphism of the GPX1 gene using PCR-RFLP methods. The association of 198Pro/Leu GPX1 genotype (OR = 1,53; p = 0,05) with susceptibility to atopic BA was found. However, the 198Pro/Leu genotype of the glutathione peroxidase-1 gene was found to be associated with atopic BA in males only (OR = 2,21; p = 0,01).Π’ΠΏΠ΅Ρ€Π²Ρ‹Π΅ ΠΈΠ·ΡƒΡ‡Π΅Π½Π° связь ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Pro198Leu Π³Π΅Π½Π° глутатионпСроксидазы-1 (GPX1) с Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ аллСргичСской ΠΈ нСаллСргичСской Ρ„ΠΎΡ€ΠΌ Π±Ρ€ΠΎΠ½Ρ…ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ астмы (БА). ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠΌ для исслСдования послуТила популяционная Π²Ρ‹Π±ΠΎΡ€ΠΊΠ° русских ΠΆΠΈΡ‚Π΅Π»Π΅ΠΉ Π¦Π΅Π½Ρ‚Ρ€Π°Π»ΡŒΠ½ΠΎΠ§Π΅Ρ€Π½ΠΎΠ·Π΅ΠΌΠ½ΠΎΠ³ΠΎ Ρ€Π΅Π³ΠΈΠΎΠ½Π° России (213 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… БА ΠΈ 205 Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄ΠΎΠ±Ρ€ΠΎΠ²ΠΎΠ»ΡŒΡ†Π΅Π²). Π“Π΅Π½ΠΎΡ‚ΠΈΠΏΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Pro198Leu Π³Π΅Π½Π° GPX1 ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°Π·Π½ΠΎΠΉ Ρ†Π΅ΠΏΠ½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ (ПЦР) ΠΈ посрСдством Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π΄Π»ΠΈΠ½ рСстрикционных Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚ΠΎΠ² (ΠŸΠ”Π Π€). УстановлСно, Ρ‡Ρ‚ΠΎ частота Π³Π΅Ρ‚Π΅Ρ€ΠΎΠ·ΠΈΠ³ΠΎΡ‚ 198L/P Π±Ρ‹Π»Π° Π²Ρ‹ΡˆΠ΅ срСди Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… аллСргичСской БА, Ρ‡Π΅ΠΌ срСди Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΠΎΠ² (OR = 1,53; p = 0,05). Однако обнаруТСнная Π½Π°ΠΌΠΈ Π²ΠΏΠ΅Ρ€Π²Ρ‹Π΅ ассоциация ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Pro198Leu Π³Π΅Π½Π° GPX1 с аллСргичСской БА Π±Ρ‹Π»Π° Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½Π° Ρ‚ΠΎΠ»ΡŒΠΊΠΎ для ΠΌΡƒΠΆΡ‡ΠΈΠ½ (OR = 2,21, p = 0,01)

    Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.

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    BACKGROUND: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma. METHODS: We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects. RESULTS: First approach: 50 SNPs were selected based on an overall interaction effect at p<10-4. The most pronounced interaction effect was observed for rs9969775 on chromosome 9 (discovery meta-analysis: ORint = 0.50, p = 7.63*10-5, replication: ORint = 0.65, p = 0.02). Second approach: 35 SNPs were selected based on the overall genetic effect in exposed subjects (p <10-4). The most pronounced genetic effect was observed for rs5011804 on chromosome 12 (discovery meta-analysis ORint = 1.50, p = 1.21*10-4; replication: ORint = 1.40, p = 0.03). CONCLUSIONS: Using two genome-wide interaction approaches, we identified novel polymorphisms in non-annotated intergenic regions on chromosomes 9 and 12, that showed suggestive evidence for interaction with active tobacco smoking in the onset of adult asthma

    The contribution of MTHFR C677T polymorphism to peripheral artery disease in diabetic patients

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    The aim of this study was to investigate the association between functional polymorphism C677T (rs1801133) of methylenetetrahydrofolate reductase (MTHFR) gene for and risk of peripheral artery disease in diabetes patient

    The flavin-containing monooxygenase 3 gene and essential hypertension: The joint effect of polymorphism E158K and cigarette smoking on disease susceptibility

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    Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute to essential hypertension (EH). The present study was designed to investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in a Russian population. A total of 2 995 unrelated subjects from Kursk (1 362 EH patients and 843 healthy controls) and Belgorod (357 EH patients and 422 population controls) regions of Central Russia were recruited for this stud
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