La Registrazione dei Nomi a Dominio sotto il Top Level Domain .IT: L\u27oggetto ROLE

This document illustrates the \u27role\u27 object contained within the ccTLD "it" whois database. In particular, it provides the guidelines for a proper use of the object itself within the technical modules utilized to register a domain name under the ccTLD \u27.it\u27 and for a correct filling of its fields

Comparison of different approaches for landslide-induced damage assessment: the case study of Agnone (southern Italy)

Landslides constitute one of the most important geo-hazards affecting southern Italy. Particularly, in this area slope movements have over time caused relevant socio-economic losses and, in some cases, also casualties. Prevention, prediction and monitoring of landslide phenomena play a key-role to avoid or minimize their effects. In this work, damage suffered by facilities located within and surrounding a deep-seated landslide were classified through three different approaches. The investigated area is located in the municipality of Agnone (Molise region, central-south Italy), which is strongly affected by landslide processes. A main landslide event that occurred in 2003 is still active, exhibiting slow and intermittent movements. In this contribution, three different approaches for landslide-induced damage assessment are compared and their discrepancy discussed, highlighting the benefits and drawbacks of the different approaches. Finally, the future development of a new methodology and classification for infrastructures damage assessment is evaluated, merging the procedures used in this work

Il nuovo sistema di assegnazione dei nic-handle nel Registro del ccTLD "it"

This document describes the technical and operational aspects of the new nic-handle assignment system adopted by the ccTLD "it" Registry . In particular, the document shows the impact of the new system on the syntax check software as well as the registration forms and the Registry Web site

LA VALUTAZIONE EX POST DEL PROGRAMMA DI SVILUPPO RURALE DELLA REGIONE TOSCANA. STUDIO METODOLOGICO PER IL CALCOLO DELL'INDICATORE DI VALORE AGGIUNTO AZIENDALE

Il presente lavoro di ricerca si inserisce nell’ambito del processo di valutazione ex post del Programma di Sviluppo Rurale (PSR) 2007-2013 della Regione Toscana. Rispetto alla programmazione precedente, il Reg. (CE) 1698/2005 sullo sviluppo rurale ha introdotto un approccio al monitoraggio ed alla valutazione più sistematico, strutturato e “standardizzato”, prevedendo l’utilizzo di una serie di indicatori comuni a tutti gli Stati membri. Il citato regolamento ha infatti istituito il “Quadro Comune di Monitoraggio e Valutazione” (QCMV). Al fine di chiarire gli aspetti operativi, la Commissione (DG Agricoltura e Sviluppo Rurale) ha pubblicato un documento di orientamento (Manuale del Quadro Comune per il Monitoraggio e la Valutazione) contenente la lista degli indicatori e le linee guida per il loro utilizzo. Gli indicatori previsti seguono una precisa gerarchia che corrisponde ai vari livelli di intervento: prodotti, risultati, impatti. Gli indicatori sono utilizzati come strumenti per valutare, ad ogni livello, il grado di raggiungimento degli obiettivi. Il presente studio ha come oggetto la sperimentazione della metodologia individuata dalla Commissione per il calcolo dell’indicatore di risultato “Variazione del valore aggiunto aziendale lordo”. L’arco temporale di osservazione va dal 2004 al 2008. Infatti, per motivi tecnici, legati alla disponibilità dei dati, abbiamo applicato la metodologia ai dati contabili, presenti nella banca dati RICA Toscana, delle aziende beneficiarie del PSR nella programmazione 2000-2006. L’obiettivo di questa “simulazione” è duplice: i) mettere in evidenza i punti critici che si possono incontrare nel corso della procedura, a partire dalla raccolta dei dati fino alla loro elaborazione; ii) valutare il grado di attendibilità della metodologia prescritta, analizzando gli esiti a cui questa può condurre. La parte sperimentale del presente lavoro, è preceduta da una sezione introduttiva, in cui si tracciano gli orientamenti generali della politica di sviluppo rurale, a livello europeo, ed i concetti chiave per la sua valutazione. Viene tracciata una breve storia del percorso che dall’impostazione tradizionale della PAC, incentrata sul sostegno alla produzione agricola, ha portato all’attuale politica di sviluppo rurale, il cui riferimento normativo è costituito dal Regolamento (CE) n.1698/2005. Vengono descritte le principali novità introdotte, con particolare attenzione al tema della valutazione, di cui vengono illustrati i principi generali e gli aspetti operativi legati al QCMV

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma

The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti-neoplastic effects in vitro may not be reached in tumour patients. In this study, we tested in vitro and in vivo effects of two VPA-derivatives (ACS2, ACS33) on pre-clinical prostate cancer models. PC3 and DU-145 prostate tumour cell lines were treated with various concentrations of ACS2 or ACS33 to perform in vitro cell proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and to evaluate tumour cell adhesion to endothelial cell monolayers. Analysis of acetylated histones H3 and H4 protein expression was performed by western blotting. In vivo tumour growth was conducted in subcutaneous xenograft mouse models. Tumour sections were assessed by immunohistochemistry for histone H3 acetylation and proliferation. ACS2 and ACS33 significantly up-regulated histone H3 and H4 acetylation in prostate cancer cell lines. In micromolar concentrations both compounds exerted growth arrest in PC3 and DU-145 cells and prevented tumour cell attachment to endothelium. In vivo, ACS33 inhibited the growth of PC3 in subcutaneous xenografts. Immunohistochemistry and western blotting confirmed increased histone H3 acetylation and reduced proliferation. ACS2 and ACS33 represent novel VPA derivatives with superior anti-tumoural activities, compared to the mother compound. This investigation lends support to the clinical testing of ACS2 or ACS33 for the treatment of prostate cancer

Integration of field investigations and remote sensing techniques for the assessment of landslide activity and damage

The aim of the PhD thesis was to look for a relationship between the landslide-induced damage recorded on structures and facilities based on the results of several field campaigns and kinematic parameters quantitatively estimated by remote sensing techniques. Investigations were developed on two test sites: a deep-seated landslide in Colle Lapponi-Piano Ovetta in municipality of Agnone (Molise region, southern Italy) and the landslides affecting the southwestern sector of Volterra (Tuscany region, central Italy). First of all, a re-enactment of the evolution of both landslides were conducted, by means of 3D reconstructions based on historical aerial series of images and the analysis of Persistent Scatterers of ERS1/2, ENVISAT and COSMO-SkyMed satellites. The 3D Points Clouds and models were developed on several sets of aerial historical images dating from different years starting from 1945 and 1954 for Agnone and Volterra, respectively. To better understand the morpho-evolutionary stages, a qualitative assessment of changes of volume were made combining the oldest and the latest 3D reconstructed Points Clouds. This interpretation, even if qualitative and not quantitative, can be helpful for understanding possible effects of future reactivations and as a support to realize mitigation plans, susceptibility maps and other useful for the local administrators. The Persistent Scatterers were used to monitor the evolution in recent years, up to 2015. Then, for both case studies, the damage was revealed on structures and facilities by several field surveys and classified by means of five literature damage categorizations. During their application, some drawbacks and benefits of the methodologies were carried out and a new approach to improve the categorization of the damage on structures, facilities and ground surfaces was developed. This was conceived in two subsequent phases: i) a classification to use during the field campaign to quantify the severity of cracks and fractures on structures, facilities and ground surfaces; ii) an a posteriori ranking to apply on the entire structure, involving the extension of damage classes, performed by a cell-grid matrix. Furthermore, a damage recording scheme, useful for the recognition of cracks and fractures during the field surveys, was proposed. A critical comparison between the results obtained applying the different classification approaches, then followed. Buildings and facilities, for both sites, were categorized using also kinematic parameters such as velocity and maximum displacement measured along the Line Of Sight, derived by A-DInSAR, and their absolute values re-projected along the steepest local slope. Once characterized and categorized all structures and facilities of both sites of interest, a correlation between the surveyed damage classes and the deriving parameters by satellite were looked for. The investigation was carried to understand the behaviour of entire structures, subject to displacements. The first analysis was conducted on the Agnone test site where for several constructions an upper regression line between damage categories and velocity reprojected along the slope was recognized. Some outlayers were identified, mainly for low damage levels, then singularly investigated. To assess the reliability of all the structures, a matrix involving damage and velocity along the slope parameter acquired by ENVISAT and COSMO-SkyMed sensors was developed in order to obtain a classification. To validate the correlation and the reliability matrix the same procedure was applied to the Volterra site. Once asserted the validity of the relation between the velocity reprojected along the steepest slope and the classes of damage also for this area, the reliability matrix was applied on the constructions of the Volterra site. In this way, the relation between the displacement occurred during the period covered by ENVISAT and COSMO-SkyMed shows how the surveyed damage construction are related to the displacement. Some areas where damage occurred in the 2000 shows high reliability with ENVISAT recorded velocity, while others structures exhibits high reliability with COSMO-SkyMed data. The results were interesting because they highlight the fact that for some construction there is correlation between velocity of displacement of the entire structure and affecting damage; for others, instead, the high damage is related to the differential settlement and not necessarily to a high rate of displacement velocity

Presente e futuro della rilevazione: come i nuovi strumenti digitali cambiano il modo di raccogliere i dati nelle ricerche di mercato

Presente e futuro della rilevazione: come i nuovi strumenti digitali cambiano il modo di raccogliere i dati nelle ricerche di mercat