Processing Oscillatory Data with PDV

Author Institution: Lawrence Livermore National LaboratorySlides presented at the 2nd Annual Photonic Doppler Velocimetry (PDV) Workshop held at Lawrence Livermore National Laboratory, Livermore, California, August 16-17, 2007

People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population

There is a great deal of interest in fine scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to play a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. Here we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK control population that can be used as a resource by the research community as well as providing fine scale genetic information on the British population. So far, some 4,000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3,865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1,057 samples demonstrates the value of these samples for investigating fine scale population structure within the UK, and shows how this can be enhanced by the use of surnames

MFA09 (MFA 2009)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum in 2009. Content includes A new paradigm / Carmon Colangelo -- Evolving practices / Patricia Olynyk -- Stephanie Barenz -- Carolyn Dawn Bendel -- Jacob Cruzen -- Rachel Ann Dennis -- Bryan Eaton -- Maya Escobar -- Meredith Foster -- Morgan Gehris -- Gina Grafos -- Stephen Hoskins -- Amelia Jones -- Hye Young Kim -- Anne Lindberg -- Goran Maric -- Kelda Martensen -- Erica L. Millspaugh -- Carianne Noga -- Joel Parker -- Rebecca C. Potts -- Shannon Randol -- Elaine Rickles -- Michael Kenneth Smith -- Dan Solberg -- Natalie Toney -- Glenn Tramantano -- Kathryn Trout -- J. Taylor Wallace.https://openscholarship.wustl.edu/books/1006/thumbnail.jp

Antioxidant Protects against Increases in Low Molecular Weight Hyaluronan and Inflammation in Asphyxiated Newborn Pigs Resuscitated with 100% Oxygen

BACKGROUND: Newborn resuscitation with 100% oxygen is associated with oxidative-nitrative stresses and inflammation. The mechanisms are unclear. Hyaluronan (HA) is fragmented to low molecular weight (LMW) by oxidative-nitrative stresses and can promote inflammation. We examined the effects of 100% oxygen resuscitation and treatment with the antioxidant, N-acetylcysteine (NAC), on lung 3-nitrotyrosine (3-NT), LMW HA, inflammation, TNFα and IL1ß in a newborn pig model of resuscitation. METHODS & PRINCIPAL FINDINGS: Newborn pigs (n = 40) were subjected to severe asphyxia, followed by 30 min ventilation with either 21% or 100% oxygen, and were observed for the subsequent 150 minutes in 21% oxygen. One 100% oxygen group was treated with NAC. Serum, bronchoalveolar lavage (BAL), lung sections, and lung tissue were obtained. Asphyxia resulted in profound hypoxia, hypercarbia and metabolic acidosis. In controls, HA staining was in airway subepithelial matrix and no 3-NT staining was seen. At the end of asphyxia, lavage HA decreased, whereas serum HA increased. At 150 minutes after resuscitation, exposure to 100% oxygen was associated with significantly higher BAL HA, increased 3NT staining, and increased fragmentation of lung HA. Lung neutrophil and macrophage contents, and serum TNFα and IL1ß were higher in animals with LMW than those with HMW HA in the lung. Treatment of 100% oxygen animals with NAC blocked nitrative stress, preserved HMW HA, and decreased inflammation. In vitro, peroxynitrite was able to fragment HA, and macrophages stimulated with LMW HA increased TNFα and IL1ß expression. CONCLUSIONS & SIGNIFICANCE: Compared to 21%, resuscitation with 100% oxygen resulted in increased peroxynitrite, fragmentation of HA, inflammation, as well as TNFα and IL1ß expression. Antioxidant treatment prevented the expression of peroxynitrite, the degradation of HA, and also blocked increases in inflammation and inflammatory cytokines. These findings provide insight into potential mechanisms by which exposure to hyperoxia results in systemic inflammation

Forest damage and forest monitoring in Norway. Annual report of the Norwegian Monitoring Programme for Forest Damage 1999

Overvåkingsprogram for skogskader (OPS) har vært i drift siden 1986. Formålet har vært å overvåke skogtilstanden i forhold til luftforurensninger. Registreringer blir utført i to landsdekkende flatenett og et nett av intensive overvåkingsflater. Skogens tilstand, basert på vurderinger av trekroner har i mange år vært nedadgående (redusert kronetetthet og flere misfargete trær), særlig for granskogen. Denne tendensen kan imidlertid være i ferd med å snu. Resultatene for de to siste årene har vist en liten forbedring. På landsbasis er det ikke registrert unormal avdøing av trær. Resultater fra skogøkologiske undersøkelser på intensivflater, som er representative for mye av skogen rundt om i Norge, viser at skogøkosystemet er stabilt og har en rimelig god status. Skogens helsetilstand avhenger i stor grad av jordsmonn, trealder, klima, skadegjørere og andre naturlige stressfaktorer. Når trær skranter skyldes dette ofte et samspill mellom alder, klima, voksestedsbetingelser og sjukdommer. Tilførsler av luftforurensninger vil komme i tillegg til, og i samspill med disse forholdene. Bidraget fra forurensningene er vanskelig å fastslå fordi denne påvirkningen oftest er svært liten i forhold til de andre forholdene. Men dette betyr ikke at luftforurensningnes mulige predisponerende betydning må utelukkes. I fremtiden vil trolig eventuelle utslag av et endret klima spille en større rolle.Forest damage and forest monitoring in Norway. Annual report of the Norwegian Monitoring Programme for Forest Damage 1999publishedVersio

Skogskader og skogovervåking i Norge. Årsrapport for Overvåkingsprogram for skogskader 2000

publishedVersio

Nordic Growth Entrepreneurship Review 2012

In recent years, the Nordic countries have improved the framework conditions for entrepreneurship and thereby continued the development that has taken place over the last decades. In important areas, the framework conditions for entrepreneurship in the Nordic countries are as strong as those in the best-performing countries