Let the trajectories tell a quantum story: Post-entangling the SHARC scheme

A new method is proposed to perform Quantum Wave Packet Nuclear Dynamics on large systems, by making use of information obtained by Semi-Classical Quantum Dynamics. The key of the method resides in expressing the nuclear wave function of the system in a basis set determined by the positions of multiple trajectories at each tim

Analytical solution of the optimal laser control problem in two-level systems

The optimal control of two-level systems by time-dependent laser fields is studied using a variational theory. We obtain, for the first time, general analytical expressions for the optimal pulse shapes leading to global maximization or minimization of different physical quantities. We present solutions which reproduce and improve previous numerical results.Comment: 12 pages, 2 figure

Solving the main cosmological puzzles with a generalized time varying vacuum energy

We study the dynamics of the FLRW flat cosmological models in which the vacuum energy density varies with time, $\Lambda(t)$. In particular, we investigate the dynamical properties of a generalized vacuum model and we find that under certain conditions the vacuum term in the radiation era varies as $\Lambda(z) \propto (1+z)^{4}$, while in the matter era we have $\Lambda(z)\propto (1+z)^{3}$ up to $z\simeq 3$ and $\Lambda(z)=\Lambda$ for $z\le 3$. The confirmation of such a behavior would be of paramount importance because it could provide a solution to the cosmic coincidence problem as well as to the fine tuning problem, without changing the well known (from the concordance $\Lambda$ cosmology) Hubble expansion.Comment: 9 pages, 2 figures, Accepted for publication by Astronomy and Astrophysic

Seguimiento farmacoterapéutico en las prácticas tuteladas: aplicación de la metodología Dáder en la identificación de PRM

Within the framework of the subject “Practical Work Experience” forming part of the Pharmacy course at the NationalUniversity of Cordoba, Argentina, fifth year students carry out practical work in community pharmacies. This universitycourse, tutored by professional pharmacists, includes the pharmacotherapeutic monitoring of patients, using Dádermethodology, as one of its activities.In this study, the students ability to recognise Adverse Drug Reactions (ADR) is evaluated during the year 2001, anda comparison of the results is made with those obtained from a similar study carried out by professional communitypharmacists in August of the year 2000.50 students, supervised by pharmacist tutors, carried out the identification of ADR. Of the patients that were monitored(n=50): 70% were women; with a predominant age group from 70 to 79 years of age (34%) and an average of medicines/patient of 7.6±2.1 (range: 0-12); average ADR identified per patient 5.6±5.0 (range: 1-23).The standard of the teaching, at pre-graduate level, of Dáder methodology evaluated through the comparison of resultsbetween students and pharmacists, gave satisfactory results.En el marco de la asignatura “Practicanato Profesional” de la Carrera de Farmacia de la Universidad Nacional deCórdoba (Argentina), los alumnos del quinto año desarrollan sus prácticas en farmacias comunitarias. Allí cuentancon farmacéuticos tutores y, entre las actividades desarrolladas, se incluye el seguimiento farmacoterapéutico depacientes empleando la metodología Dáder.En este trabajo se evalúa la capacidad de los alumnos para identificar PRM, durante el año 2001, y se comparan,para fines académicos, con los resultados presentados por farmacéuticos comunitarios en agosto de 2000.50 alumnos realizaron la identificación de PRM supervisados por farmacéuticos tutores. De los pacientes bajoseguimiento (n=50): 70% fueron mujeres; grupo etario predominante, de 70 a 79 años (34%); promedio de medicamentos/paciente 7.6±2.1 (rango: 0-12); promedio de PRM identificados por paciente 5.6±5.0 (rango: 1-23).La calidad de la enseñanza de la metodología Dáder en el pregrado arrojó resultados satisfactorios al comparar entrealumnos y farmacéuticos

Physical and mathematical modeling of wave propagation in the Ariane 5 VEB structure

The separation of the lower stage of the ARIANE 5 Vehicle Equipment Bay (VEB) Structure is to be done using a pyrotechnic device. The wave propagation effects produced by the explosion can affect the electronic equipment, so it was decided to analyze, using both physical and numerical modeling, a small piece of the structure to determine the distribution of the accelerations and the relative importance of damping, stiffness, connections, etc. on the response of the equipment

Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy (AAK). Due to the characteristics of AAK and its bilateral nature, clinical management is challenging and complicated by the multiple coexisting ocular and systemic morbidities in aniridia. Although it is primarily assumed that AAK originates from a congenital limbal stem cell deficiency, in recent years AAK and its pathogenesis has been questioned in the light of new evidence and a refined understanding of ocular development and the biology of limbal stem cells (LSCs) and their niche. Here, by consolidating and comparing the latest clinical and preclinical evidence, we discuss key unanswered questions regarding ocular developmental aspects crucial to AAK. We also highlight hypotheses on the potential role of LSCs and the ocular surface microenvironment in AAK. The insights thus gained lead to a greater appreciation for the role of developmental and cellular processes in the emergence of AAK. They also highlight areas for future research to enable a deeper understanding of aniridia, and thereby the potential to develop new treatments for this rare but blinding ocular surface disease

Experiencia con la metodología Dáder de seguimiento farmacoterapéutico en el pre-grado: encuesta a los alumnos

In the field of pharmaceutical studies, the inclusion of tutored practical experience is considered as a priority in theeducation of pre-graduate students. In the year 2001, the subject Practical Work Experience during the pharmacy degreecourse at the Faculty of Chemical Sciences, National University of Córdoba, was carried out, with the collaboration ofpharmacist tutors, participants in the Dáder program, in the Province of Córdoba, Argentina. Under their supervision,the students carrying out the final year of their studies, participated in practice sessions in community pharmacies. Inthe year 2001, a survey was designed in order to obtain student’s opinions of the project. On this basis, the activitiesand training tools developed, with the tutor pharmacist, were evaluated.A response rate of 89.6%, from the 48 surveys distributed, was achieved. With regard to the training received, themajority of students responded to questions 1,2, and 3, with excellent and very good. 97.7% considered the methodologyemployed as practical, and 95.3% believed that it was possible to incorporate these pharmaceutical care activities intotheir future working practices.La formación de grado en farmacia plantea como una prioridad la inclusión de prácticas tuteladas. En el año 2001,en la asignatura Practicanato Profesional de la Carrera de Farmacia (Facultad de Ciencias Químicas, UniversidadNacional de Córdoba), se trabajó con la colaboración de farmacéuticos tutores participantes del Programa Dáderen la Provincia de Córdoba (Argentina). Bajo su supervisión, los alumnos del último año realizaron sus prácticasen Farmacias Comunitarias. Se elaboró una encuesta para conocer la opinión de los estudiantes en esta experienciay, sobre esta base, evaluar actividades y herramientas de capacitación utilizadas junto a los farmacéuticos tutores,durante el año 2001.Se alcanzó un 89,6% de respuesta sobre 48 encuestas distribuidas. Sobre la capacitación recibida, en las preguntas1, 2 y 3, las calificaciones fueron mayoritariamente entre Excelente y Muy Bueno; el 97,7% considera práctica lametodología empleada; el 95,3% considera que es posible incorporar actividades de Atención Farmacéutica en sufuturo desempeño profesional