The large scale gas and dust distribution in the galaxy: Implications for star formation

Infrared Astronomy Observations are presented for the diffuse infrared (IR) emissions from the galactic plane at wavelengths of 60 and 100 microns and the total far infrared intensity and its longitudinal variations in the disk were derived. Using available CO, 5 GHz radio-continuum, and HI data, the IR luminosity per hydrogen mass and the ingrared excess (IRE) ratio in the Galaxy were derived. The longitudinal profiles of the 60 and 100 micron emission were linearly decomposed into three components that are associated with molecular (H2), neutral (HI), and ionized (HII) phases in the interstellar medium (ISM), and the relevant dust properties were derived in each phase. Implications of the findings for various models of the diffuse IR emisison and for star formation in the galactic disk are discussed

Blockade of HIV-1 Infection of New World Monkey Cells Occurs Primarily at the Stage of Virus Entry

HIV-1 naturally infects chimpanzees and humans, but does not infect Old World monkeys because of replication blocks that occur after virus entry into the cell. To understand the species-specific restrictions operating on HIV-1 infection, the ability of HIV-1 to infect the cells of New World monkeys was examined. Primary cells derived from common marmosets and squirrel monkeys support every phase of HIV-1 replication with the exception of virus entry. Efficient HIV-1 entry typically requires binding of the viral envelope glycoproteins and host cell receptors, CD4 and either CCR5 or CXCR4 chemokine receptors. HIV-1 did not detectably bind or utilize squirrel monkey CD4 for entry, and marmoset CD4 was also very inefficient compared with human CD4. A marmoset CD4 variant, in which residues 48 and 59 were altered to the amino acids found in human CD4, supported HIV-1 entry efficiently. The CXCR4 molecules of both marmosets and squirrel monkeys supported HIV-1 infection, but the CCR5 proteins of both species were only marginally functional. These results demonstrate that the CD4 and CCR5 proteins of New World monkeys represent the major restriction against HIV-1 replication in these primates. Directed adaptation of the HIV-1 envelope glycoproteins to common marmoset receptors might allow the development of New World monkey models of HIV-1 infection

N-linked glycosylation in the CXCR4 N-terminus inhibits binding to HIV-1 envelope glycoproteins

AbstractCXCR4 is a co-receptor along with CD4 for human immunodeficiency virus type 1 (HIV-1). We investigated the role of N-linked glycosylation in the N-terminus of CXCR4 in binding to HIV-1 gp120 envelope glycoproteins. Gp120s from CXCR4 (X4) and CCR5 (R5) using HIV-1 strains bound more efficiently to non-N-glycosylated than to N-glycosylated CXCR4 proteoliposomes in a CD4-dependent manner. Similar results were observed in binding studies using non-N-glycosylated or N-glycosylated CXCR4 expressed on cells. Mutation of the N-glycosylation site N11 in CXCR4 (N11Q-CXCR4) enhanced CD4-dependent binding of X4 and R5 gp120s and allowed more efficient entry of viruses pseudotyped with X4 or R5 HIV-1 envelope glycoproteins. However, the binding of R5 gp120 to N11Q-CXCR4 and entry of R5 HIV-1 viruses into cells expressing N11Q-CXCR4 were 20- and 100- to 1000-fold less efficient, respectively, than the levels achieved using X4 gp120 or X4 HIV-1 viruses. Binding of stromal cell-derived factor (SDF)-1α, the natural ligand of CXCR4, and SDF-1α-induced signaling were reduced by the N11Q mutation. These findings demonstrate that N-glycosylation at N11 inhibits the binding of CXCR4 to X4 and R5 HIV-1 gp120, and provide a better understanding of the structural elements of CXCR4 involved in HIV-1 Env–co-receptor interactions

Molecular hydrogen beyond the optical edge of an isolated spiral galaxy

We know little about the outermost portions of galaxies because there is little light coming from them. We do know that in many cases atomic hydrogen (HI) extends well beyond the optical radius \cite{Casertano91}. In the centers of galaxies, however, molecular hydrogen (H2) usually dominates by a large factor, raising the question of whether H2 is abundant also in the outer regions but hitherto unseen.Here we report the detection of emission from carbon monoxide (CO), the most abundant tracer of H2, beyond the optical radius of the nearby galaxy NGC 4414. The molecular clouds probably formed in the regions of relatively high HI column density and in the absence of spiral density waves. The relative strength of the lines from the two lowest rotational levels indicates that both the temperature and density of the H2 are quite low compared to conditions closer to the center. The inferred surface density of the molecular material continues the monotonic decrease from the inner regions. We conclude that while molecular clouds can form in the outer region of this galaxy, there is little mass associated with them.Comment: 3 Nature page

[CII] emission and star formation in the spiral arms of M31

The CII 158 microns line is the most important coolant of the interstellar medium in galaxies but substantial variations are seen from object to object. The main source of the emission at a galactic scale is still poorly understood. Previous studies of the CII emission in galaxies have a resolution of several kpc or more so the observed emission is an average of different ISM components. The aim of this work is to study, for the first time, the CII emission at the scale of a spiral arm. We want to investigate the origin of this line and its use as a tracer of star formation. We present CII and OI observations of a segment of a spiral arm of M~31 using the Infrared Space Observatory. The CII emission is compared with tracers of neutral gas (CO, HI) and star formation (H\alpha, Spitzer 24 mu.) The similarity of the CII emission with the Ha and 24 mu images is striking when smoothed to the same resolution, whereas the correlation with the neutral gas is much weaker. The CII cooling rate per H atom increases dramatically from ~2.7e-26 ergs/s/atom in the border of the map to ~ 1.4e-25 ergs/s/atom in the regions of star formation. The CII/FIR(42-122) ratio is almost constant at 2%, a factor 3 higher than typically quoted. However, we do not believe that M~31 is unusual. Rather, the whole-galaxy fluxes used for the comparisons include the central regions where the CII/FIR ratio is known to be lower and the resolved observations neither isolate a spiral arm nor include data as far out in the galactic disk as the observations presented here. A fit to published PDR models yields a plausible average solution of G_0~100 and n~3000 for the PDR emission in the regions of star formation in the arm of M31.Comment: 8 pages, 5 figures. To be published by A&A. Low quality figures. High quality version in http://www.obs.u-bordeaux1.fr/Radio/NRodriguez/out/m31.pd

Dust-temperature of an isolated star-forming cloud: Herschel observations of the Bok globule CB244

We present Herschel observations of the isolated, low-mass star-forming Bok globule CB244. It contains two cold sources, a low-mass Class 0 protostar and a starless core, which is likely to be prestellar in nature, separated by 90 arcsec (~ 18000 AU). The Herschel data sample the peak of the Planck spectrum for these sources, and are therefore ideal for dust-temperature and column density modeling. With these data and a near-IR extinction map, the MIPS 70 micron mosaic, the SCUBA 850 micron map, and the IRAM 1.3 mm map, we model the dust-temperature and column density of CB244 and present the first measured dust-temperature map of an entire star-forming molecular cloud. We find that the column-averaged dust-temperature near the protostar is ~ 17.7 K, while for the starless core it is ~ 10.6K, and that the effect of external heating causes the cloud dust-temperature to rise to ~ 17 K where the hydrogen column density drops below 10^21 cm^-2. The total hydrogen mass of CB244 (assuming a distance of 200 pc) is 15 +/- 5 M_sun. The mass of the protostellar core is 1.6 +/- 0.1 M_sun and the mass of the starless core is 5 +/- 2 M_sun, indicating that ~ 45% of the mass in the globule is participating in the star-formation process.Comment: Accepted for A&A Herschel Special Issue; 5 pages, 2 figure

Nuclear starburst-driven evolution of the central region in NGC 6764

We study the CO and the radiocontinuum emission in an active galaxy to analyze the interplay between the central activity and the molecular gas. We present new high-resolution observations of the CO(1-0) and CO(2-1) emission lines, and 3.5 cm and 20 cm radio continuum emission in the central region of the LINER/starburst galaxy NGC 6764. The galaxy has an outflow morphology in radio continuum, spatially coincident with the CO and H$\alpha$ emission, and centered slightly off the radio continuum peak at the LINER nucleus. The total molecular gas mass in the center is about 7x10^8 \msun, using a CO luminosity to total molecular gas conversion factor that is three times lower than the standard one. CO(1-0) emission is found near the boundaries of the radio continuum emission cone. The outflow has a projected expansion velocity of 25 km/s relative to the systemic velocity of NGC6764. About 4x 10^6 \msun of molecular gas is detected in the outflow. The approximate location (~1 kpc) of the dynamical inner Lindblad resonance has been derived from the rotation curve. The peak of the CO emission is slightly (< 200 pc) offset from the peak of the radio continuum. The molecular gas has most likely been ejected by the stellar winds from the recent starburst, but the CO line ratios show indication of an interaction with the AGN. The energy released by the nuclear starburst is sufficient to explain the observed outflow, even if the data cannot exclude the AGN from being the major energy source. Comparison of the outflow with hydrodynamical simulations suggests that the nuclear starburst is 3--7 Myr old and the bubble-like outflow is still confined and not freely expanding.Comment: Accepted for publication in A&

A Broadband Study of Galactic Dust Emission

We have combined infrared data with HI, H2 and HII surveys in order to spatially decompose the observed dust emission into components associated with different phases of the gas. An inversion technique is applied. For the decomposition, we use the IRAS 60 and 100 micron bands, the DIRBE 140 and 240 micron bands, as well as Archeops 850 and 2096 micron wavelengths. In addition, we apply the decomposition to all five WMAP bands. We obtain longitude and latitude profiles for each wavelength and for each gas component in carefully selected Galactic radius bins.We also derive emissivity coefficients for dust in atomic, molecular and ionized gas in each of the bins.The HI emissivity appears to decrease with increasing Galactic radius indicating that dust associated with atomic gas is heated by the ambient interstellar radiation field (ISRF). By contrast, we find evidence that dust mixed with molecular clouds is significantly heated by O/B stars still embedded in their progenitor clouds. By assuming a modified black-body with emissivity law lambda^(-1.5), we also derive the radial distribution of temperature for each phase of the gas. All of the WMAP bands except W appear to be dominated by emission from something other than normal dust, most likely a mixture of thermal bremstrahlung from diffuse ionized gas, synchrotron emission and spinning dust. Furthermore, we find indications of an emissivity excess at long wavelengths (lambda > 850 micron) in the outer Galaxy (R > 8.9 kpc). This suggests either the existence of a very cold dust component in the outer Galaxy or a temperature dependence of the spectral emissivity index. Finally, it is shown that ~ 80% of the total FIR luminosity is produced by dust associated with atomic hydrogen, in agreement with earlier findings by Sodroski et al. (1997).Comment: accepted for publication by A&