Integrating Livestock and Cropping Systems: Interseeding Cereal Rye into Corn for Late Season Grazing

Corn (Zea mays) grown for grain is harvested too late in the year in many temperate regions to establish a cover crop to provide winter ground cover and an opportunity for late season grazing. The objective of this project is to evaluate the effect of interseeding cereal rye (Secale cereale) into corn for use as grazed forage after corn grain harvest on corn grain yield and additional grazing day/ha. In a 4-year study, corn was planted (64,246 plants/ha) in spring on two, 4.8-ha fields in central Pennsylvania. Cereal rye was interseeded (135 kg/ha) into the corn at the V4-V6 stage. Corn was harvested as grain in November and each field was divided into six, 0.8-ha paddocks and randomly assigned to either grazed (GRAZ) or ungrazed (NG) treatments. Beef cattle frontal-grazed three of the paddocks (four cows/paddock) in each field approximately four to five weeks after corn grain harvest and, if growth allowed, again in early spring before subsequent corn planting. Corn fodder (after grain harvest), corn grain and cereal rye yields were monitored each fall. Cereal rye growth was also monitored in early spring. On average, the cereal rye (plus the corn stover) provided enough forage for an additional 115-130 grazing days/ha in the fall. While early spring growth has the potential to provide even greater forage yields than fall, growth is much less dependable than fall. Corn grain yields did not decrease as a result of grazing, or of repeated plantings of corn year to year, ranging from 9,516-10,088 kg/ha across GRAZ and NG paddocks except in 2019 (dry year) when corn grain yields averaged 6,053 kg/ha across both GRAZ and NG treatments

Magnetic states of linear defects in graphene monolayers: effects of strain and interaction

The combined effects of defect-defect interaction and of uniaxial or biaxial strains of up to 10\% on the development of magnetic states on the defect-core-localized quasi-one-dimensional electronic states generated by the so-called 558 linear extended defect in graphene monolayers are investigated by means of {\it ab initio} calculations. Results are analyzed on the basis of the heuristics of the Stoner criterion. We find that conditions for the emergence of magnetic states on the 558 defect can be tuned by uniaxial tensile parallel strains (along the defect direction) at both limits of isolated and interacting 558 defects. Parallel strains are shown to lead to two cooperative effects that favor the emergence of itinerant magnetism: enhancement of the DOS of the resonant defect states in the region of the Fermi level and tuning of the Fermi level to the maximum of the related DOS peak. A perpendicular strain is likewise shown to enhance the DOS of the defect states, but it also effects a detunig of the Fermi level that shifts away from the maximum of the DOS of the defect states, which inhibts the emergence of magnetic states. As a result, under biaxial strains the stabilization of a magnetic state depends on the relative magnitudes of the two components of strain.Comment: 9 pages 8 figure

Intake and Milk Production of Lactating Dairy Cows Grazing Diverse Forage Mixtures Over Two Grazing Seasons

Voluntary intake and stocking rate are key determinants of animal performance on pasture. Greater plant diversity in grassland plant communities has been linked to increased primary production, greater stability in response to disturbance, and reduced weed pressure. Thus, increasing plant diversity may be one approach to improving animal productivity. An experiment was conducted to determine the effects of forage diversity on intake and milk production of lactating dairy cows over two grazing seasons

Brix as an Indicator of Sugar Content and Nutritive Value in Alfalfa and Orchardgrass Herbage

Brix, a measurement of total dissolved solids in solution, has been used by forage producers to provide real-time estimates of energy content of fresh herbage. However, its efficacy has never been validated in herbage through wet chemistry testing and comparisons with other nutritive value parameters. This study compared and correlated Brix measurements with sugar concentrations and common nutritive value parameters relating to protein, fiber, and energy to determine the viability of using Brix to predict when to graze or harvest fresh herbage. Brix measurements were collected monthly on fresh herbage samples of alfalfa (Medicago sativa L.) and orchardgrass (Dactylis glomerata L.) from May to August in 2019 and 2021. Herbage was immediately flash frozen with liquid nitrogen and analyzed for sugar concentration and nutritive value. Brix did not differ among sampling dates for alfalfa and only differed at the May sampling for orchardgrass, indicating that Brix values were not affected by harvest date during late spring and summer months. When correlated across all sampling dates, Brix was positively correlated to sugar concentrations, reduced fiber, and greater net energy concentrations in alfalfa, but not positively correlated to any nutritive value parameters in orchardgrass. These results indicated that Brix should be used only in a limited fashion to predict energy content of fresh herbage and is more reliable when used with legumes than grasses

Electrochemical Boron-Doped Diamond Film Microcells Micromachined with Femtosecond Laser: Application to the Determination of Water Framework Directive Metals

Planar electrochemical microcells were micromachined in a microcrystalline boron-doped diamond (BDD) thin layer using a femtosecond laser (Photo 1). The electrochemical performances of the new laser-machined BDD microcell were assessed by differential pulse anodic stripping voltammetry (DPASV) determinations, at nM level, of the four heavy metal ions of the European Water Framework Directive (WFD): Cd(II), Ni(II), Pb(II), Hg(II). The results are compared with those of previously published BDD electrodes [1]. The calculated detection limits are 0.4 nM, 6.8 nM and 5.5 nm 2.3 nM, and the linearities go up to 35nM, 97nM, 48nM and 5nM for respectively Cd(II), Ni(II) Pb(II) and Hg(II). The detection limits meet with the environmental quality standard of the WFD for three of the four metals. It was shown that the four heavy metals could be detected simultaneously, in the concentration ratio usually measured in sewage or runoff waters

Nash-wo-Numa (childhood growth & development) study protocol: Factors that impact linear growth in children 9 to 15 years of age in Matiari, Pakistan

Introduction: Adolescence is a time of significant physical and emotional change, and there is emerging concern that adolescents living in low- and middle-income countries (LMIC) may face substantial challenges in relation to linear growth and mental health. Data on the global burden of stunting after 5 years of age are limited, but estimates suggest up to 50 per cent of all adolescents in some LMIC are stunted. Additionally, many LMIC lack robust mental health care delivery systems. Pakistan has one of the world\u27s largest populations of adolescents (10 to 19 years) at approximately 40 million. The Nash-wo-Numa study\u27s primary objective is to assess the prevalence and risk factors for stunting among early adolescents in rural Pakistan. The study also aims to determine the prevalence of poor mental health and identify factors associated with common mental health concerns during the childhood to adulthood transition.Methods: This cross-sectional study will include girls (n= 738) 9.0 to 14.9 years of age and boys (n=687) 10.0 to 15.9 years of age who live in the rural district of Matiari, Pakistan. Participants will be assessed for anthropometrical measures, puberty development, nutritional biomarkers as well as symptoms of depression, anxiety and trauma using validated scales.Ethics and Dissemination: The proposed study aims to complete the picture of child and adolescent health concerning linear growth and mental health by including puberty indicators. Ethics approval has been granted by the Ethics Review Committee at the Aga Khan University, Karachi, Pakistan, #5251-WCH-ERC-18 and Research Ethics Board at SickKids Hospital, Toronto, Canada, #:1000060684. Study results will be presented at relevant conferences and published in peer-reviewed journals

Abnormal macrophage response to microbial stimulus in a 43-year-old man with a severe form of atherosclerosis: a case report

<p>Abstract</p> <p>Introduction</p> <p>New evidence indicates infections are emerging as risk factors for atherosclerosis although their specific role in the development and progression of atherosclerosis is still unclear.</p> <p>Case presentation</p> <p>A 43-year-old Caucasian man who had been treated for four years for multiple sclerosis progressively manifested systemic hypertension, polycythemia, peripheral arterial occlusion with intermittent claudication, and persistent headaches. In 2006, an instrumental analysis (magnetic resonance imaging) of our patient revealed widespread fibrocalcific atherosclerotic lesions which accounted for all his current symptoms, including those related to microbial stimulus. Two particular aspects were of interest, namely a lack of conventional cardiovascular risk factors and a negative family history for cardiovascular events. His chemical blood tests all yielded negative findings although a low positive hepatitis C virus-ribonucleic acid titer was detected. The titer had progressively increased and worsening atherosclerosis threatened the life of our patient. Interferon therapy was not appropriate for our patient due to the severe adverse effects observed shortly after its administration.</p> <p>Conclusions</p> <p>The reaction of individual cells to infections may provide an explanation as to why individuals with a similar microbial burden, corrected for the presence of other risk factors, display a different susceptibility to developing or worsening atherosclerosis. The identification of susceptible individuals and the treatment even of silent infections may provide an additional tool against atherosclerosis and its clinical complications. The evaluation of cell susceptibility before and after the correction of risk factors may contribute to the assessment of the efficacy of drug therapy.</p

Interleukin-2/interferon-α2a/13-retinoic acid-based chemoimmunotherapy in advanced renal cell carcinoma: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)

We performed a prospectively randomised clinical trial to compare the efficacy of four subcutaneous interleukin-2-(sc-IL-2) and sc interferon-α2a (sc-IFN-α2a)-based outpatient regimens in 379 patients with progressive metastatic renal cell carcinoma. Patients with lung metastases, an erythrocyte sedimentation rate ⩽70 mm h−1 and neutrophil counts ⩽6000 μl−1 (group I) were randomised to arm A: sc-IL-2, sc-IFN-α2a, peroral 13-cis-retinoic acid (po-13cRA) (n=78), or arm B: arm A plus inhaled-IL-2 (n=65). All others (group II) were randomised to arm C: arm A plus intravenous 5-fluorouracil (iv-5-FU) (n=116), or arm D: arm A plus po-Capecitabine (n=120). Median overall survival (OS) was 22 months (arm A; 3-year OS: 29.7%) and 18 months (arm B; 3-year OS: 29.2%) in group I, and 18 months (arm C; 3-year OS: 25.7%) and 16 months (arm D; 3-year OS: 32.6%) in group II. There were no statistically significant differences in OS, progression-free survival, and objective response between arms A and B, and between arms C and D, respectively. Given the known therapeutic efficacy of sc-IL-2/sc-INF-α2a/po-13cRA-based outpatient chemoimmunotherapies, our results did not establish survival advantages in favour of po-Capecitabine vs iv-5-FU, and in favour of short-term inhaled-IL-2 in patients with advanced renal cell carcinoma receiving systemic cytokines