The Practice and Potential of Renewable Energy Localisation: Results from a UK Field Trial

open access articleThe adaptation of electricity demand to match the non-despatchable nature of renewable generation is one of the key challenges of the energy transition. We describe a UK field trial in 48 homes of an approach to this problem aimed at directly matching local supply and demand. This combined a community-based business model with social engagement and demand response technology employing both thermal and electrical energy storage. A proportion of these homes (14) were equipped with rooftop photovoltaics (PV) amounting to a total of 45 kWp; the business model enabled the remaining 34 homes to consume the electricity exported from the PV-equipped dwellings at a favourably low tariff in the context of a time-of-day tariff scheme. We report on the useful financial return achieved by all participants, their overall experience of the trial, and the proportion of local generation consumed locally. The energy storage devices were controlled, with user oversight, to respond automatically to signals indicating the availability of low cost electricity either from the photovoltaics or the time of day grid tariff. A substantial response was observed in the resulting demand profile from these controls, less so from demand scheduling methods which required regular user configuration. Finally results are reported from a follow-up fully commercial implementation of the concept showing the viability of the business model. We conclude that the sustainability of the transition to renewable energy can be strengthened with a community-oriented approach as demonstrated in the trial that supports users through technological change and improves return on investment by matching local generation and consumption

Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications

When adorned with n-octyl chains azobenzene is able to disrupt a variety of calcein-loaded phospholipid liposomes. The levels of lysis observed are dependent both on the lipid headgroup and the conformation of the azobenzene compound. In all cases studied, it has been shown that the cis-conformer is more membrane-interactive than the trans-conformer, suggesting that this class of molecule could be optimised for photo-dynamic therapy applications against infectious pathogens

Making Legacy Thermal Storage Heating fit for the Smart Grid

Collaborative paper with Oxford University Environmental Change Institute and Energy Local Ltd. The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Thermal storage heaters, charged using overnight off-peak electricity, have been used for domestic space heating in the UK and other countries since the 1980s. However, they have always been difficult for consumers to manage efficiently and, with the advent of a high proportion of renewables in the electricity generation mix, the time of day when they are charged needs to be more flexible. There is also a need to reduce peaks in the demand profile to allow distribution networks to support new sources of demand such as electric vehicles. We describe a trial of a smart control system that was retrofitted to a group of six dwellings with this form of heating, with the objectives of providing more convenient and efficient control for the users while varying the times at which charging is performed, to flatten the profile of demand and make use of locally-generated renewable electricity. The trial also employs a commercially-realistic combination of a static time-of-day tariff with a real time tariff dependent on local generation, to provide consumers with the opportunity and incentive to reduce their costs by varying times of use of appliances. Results from operation over the 2015-16 heating season indicate that the objectives are largely achieved. It is estimated that on an annualised and weather-adjusted basis most of the users have consumed less electricity than before intervention and their costs are less on the trial tariffs. Critical factors for success of this form of system are identified, particularly the need to facilitate hands-on control of heating by thrifty users and the importance of an effective and sustained user engagement programme when introducing the technology, to ensure users gain confidence through a readily-accessible source of support and advice

Managing complexity in the smart grid through a new approach to demand response

CASCADE was a consortium project with Cranfield UniversityAdoption of weather-dependent renewable generation of electricity has introduced additional complexity to the challenge of maintaining a dynamic equilibrium between generation and electricity demand. At the same time the need for electricity to power heating and transport in place of fossil fuels will lead to congestion in distribution networks. Part of the solution will be to manage domestic electricity demand using signals between the smart grid and smart home, but this must be done in a way that does not provoke further instability. We use an agent-based model of household electricity consumption and supply to show how the complexity of domestic demand can be shaped allowing it to make a contribution to system stability. A possible role for this method in balancing conflicting interests between electricity consumers, suppliers, and distribution network operators is discussedEPSRC under the CASCADE project (EP/GO59969/1

Anionic Host Defence Peptides from the Plant Kingdom: Their Anticancer Activity and Mechanisms of Action

It is becoming increasingly clear that plants, ranging from across the plant kingdom produce anionic host defence peptides (AHDPs) with potent activity against a wide variety of human cancers cells. In general, this activity involves membrane partitioning by AHDPs, which leads to membranolysis and / or internalization to attack intracellular targets such as DNA. Several models have been proposed to describe these events including: the toroidal pore and Shai-Matsuzaki-Huang mechanisms but, in general, the mechanisms underpinning the membrane interactions and anticancer activity of these peptides are poorly understood. Plant AHDPs with anticancer activity can be conveniently discussed with reference to two groups: cyclotides, which possess cyclic molecules stabilized by cysteine knot motifs, and other ADHPs that adopt extended and α-helical conformations. Here, we review research into the anticancer action of these two groups of peptides along with current understanding of the mechanisms underpinning this action

Will domestic consumers take up the Renewable Heat Incentive? An analysis of the barriers to heat pump adoption using agent-based modelling

Project name is AMEN from Agent-based Modelling of Electricity Networks.The UK Government introduced the tariff-based domestic Renewable Heat Incentive (RHI) in April 2014 to encourage installation of renewable heat technologies as a key component of its carbon reduction policy. Of these, heat pumps are considered to be the most promising for widespread adoption and as such are the subject of this paper. Pilot studies prior to introduction of the policy identified non-financial barriers to uptake, such as the "hassle factor" involved, and initial figures indeed indicate that uptake is lower than expected. We analyse these non-financial barriers using an agent-based model and conclude that there is a tipping point beyond which adoption is likely to fall very sharply. We suggest that the RHI's complex and stringent compliance requirements for home inspections and heat emitter performance may well have driven adoption past this point and that further intervention may be required if the key aims of the RHI are to be achieved

The importance of passive integrated transponder (PIT) tags for measuring life-history traits of sea turtles

Capture-mark-recapture studies rely on the identification of individuals through time, using markers or tags, which are assumed to be retained. This assumption, however, may be violated, having implications for population models. In sea turtles, individual identification is typically based on external flipper tags, which can be combined with internal passive integrated transponder (PIT) tags. Despite the extensive use of flipper tags, few studies have modelled tag loss using continuous functions. Using a 26-year dataset for sympatrically nesting green (Chelonia mydas) and loggerhead (Caretta caretta) turtles, this study aims to assess how PIT tag use increases the accuracy of estimates of life-history traits. The addition of PIT tags improved female identification: between 2000 and 2017, 53% of green turtles and 29% of loggerhead turtles were identified from PIT tags alone. We found flipper and PIT tag losses were best described by decreasing logistic curves with lower asymptotes. Excluding PIT tags from our dataset led to underestimation of flipper tag loss, reproductive periodicity, reproductive longevity and annual survival, and overestimation of female abundance and recruitment for both species. This shows the importance of PIT tags in improving the accuracy of estimates of life-history traits. Thus, estimates where tag loss has not been corrected for should be interpreted with caution and could bias IUCN Red List assessments. As such, long-term population monitoring programmes should aim to estimate tag loss and assess the impact of loss on life-history estimates, to provide robust estimates without which population models and stock assessments cannot be derived accurately

Fly ash-derived MCM-41 as a low-cost silica support for polyethyleneimine in post-combustion CO2 capture

The mesoporous silicate molecular sieve, MCM-41, has been synthesized from pulverized coal fly ash (PFA), where the silicate filtrate used is a by-product from hydrothermal zeolite production. Rice husk ash was also used for comparison but fusion with sodium hydroxide was used to prepare the silicate filtrate, along similar lines to earlier reports of using PFA as a precursor for MCM-41 synthesis. The MCM-41 samples are chemically and mineralogically similar to a commercially available sample, but with higher pore volumes dominated by mesopores (0.92–1.13 cf. 0.88 cm3 g−1). After polyethyleneimine (PEI) impregnation for CO2 capture, the ash derived MCM-41 samples displayed higher uptakes than the commercial sample with the maximum achievable PEI loading of 60 Wt.% PEI (dry basis) before particle agglomeration occurs, approximately 13 compared to 11 Wt.%, respectively, the latter being comparable to earlier reports in the literature. The PFA sample that displays the fastest kinetics to achieve 90% of the equilibrium uptake had the largest mesopore volume of 1.13 cm3 g−1. Given the PFA-derived MCM-41 uses a waste silicate solution for hydrothermal preparation and no prior preparation is needed, production costs are estimated to be considerable lower where silicate solutions need to be prepared by base treatment, even if ash is used, as for the RHA derived MCM-41 used here

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

ObjectiveA pilot open label, single dose trial of fenobam, an mGluR5 antagonist, was conducted to provide an initial evaluation of safety and pharmacokinetics in adult males and females with fragile X syndrome (FXS).MethodsTwelve subjects, recruited from two fragile X clinics, received a single oral dose of 50-150 mg of fenobam. Blood for pharmacokinetic testing, vital signs and side effect screening was obtained at baseline and numerous time points for 6 h after dosing. Outcome measures included prepulse inhibition (PPI) and a continuous performance test (CPT) obtained before and after dosing to explore the effects of fenobam on core phenotypic measures of sensory gating, attention and inhibition.ResultsThere were no significant adverse reactions to fenobam administration. Pharmacokinetic analysis showed that fenobam concentrations were dose dependent but variable, with mean (SEM) peak values of 39.7 (18.4) ng/ml at 180 min after the 150 mg dose. PPI met a response criterion of an improvement of at least 20% over baseline in 6 of 12 individuals (4/6 males and 2/6 females). The CPT did not display improvement with treatment due to ceiling effects.ConclusionsClinically significant adverse effects were not identified in this study of single dose fenobam across the range of dosages utilised. The positive effects seen in animal models of FXS treated with fenobam or other mGluR5 antagonists, the apparent lack of clinically significant adverse effects, and the potential beneficial clinical effects seen in this pilot trial support further study of the compound in adults with FXS