2,634 research outputs found
A semantical approach to equilibria and rationality
Game theoretic equilibria are mathematical expressions of rationality.
Rational agents are used to model not only humans and their software
representatives, but also organisms, populations, species and genes,
interacting with each other and with the environment. Rational behaviors are
achieved not only through conscious reasoning, but also through spontaneous
stabilization at equilibrium points.
Formal theories of rationality are usually guided by informal intuitions,
which are acquired by observing some concrete economic, biological, or network
processes. Treating such processes as instances of computation, we reconstruct
and refine some basic notions of equilibrium and rationality from the some
basic structures of computation.
It is, of course, well known that equilibria arise as fixed points; the point
is that semantics of computation of fixed points seems to be providing novel
methods, algebraic and coalgebraic, for reasoning about them.Comment: 18 pages; Proceedings of CALCO 200
Reaction and Axial Vector Coupling
The reaction is studied in the region of low
to investigate the effect of deuteron structure and width of the
resonance on the differential cross section. The results are used to extract
the axial vector coupling from the experimental data on
this reaction. The possibility to determine this coupling from electroweak
interaction experiments with high intensity electron accelerators is discussed.Comment: 14 pages, REVTEX, 5 figure
Dirichlet sigma models and mean curvature flow
The mean curvature flow describes the parabolic deformation of embedded
branes in Riemannian geometry driven by their extrinsic mean curvature vector,
which is typically associated to surface tension forces. It is the gradient
flow of the area functional, and, as such, it is naturally identified with the
boundary renormalization group equation of Dirichlet sigma models away from
conformality, to lowest order in perturbation theory. D-branes appear as fixed
points of this flow having conformally invariant boundary conditions. Simple
running solutions include the paper-clip and the hair-pin (or grim-reaper)
models on the plane, as well as scaling solutions associated to rational (p, q)
closed curves and the decay of two intersecting lines. Stability analysis is
performed in several cases while searching for transitions among different
brane configurations. The combination of Ricci with the mean curvature flow is
examined in detail together with several explicit examples of deforming curves
on curved backgrounds. Some general aspects of the mean curvature flow in
higher dimensional ambient spaces are also discussed and obtain consistent
truncations to lower dimensional systems. Selected physical applications are
mentioned in the text, including tachyon condensation in open string theory and
the resistive diffusion of force-free fields in magneto-hydrodynamics.Comment: 77 pages, 21 figure
Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort
Introduction: Alzheimer's disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devastating disease have become a research priority. Consequently, the identification of clinically significant and sensitive blood biomarkers for its early detection is very important. Apolipoprotein E (APOE) is a well-known and established genetic risk factor for late-onset AD; however, the impact of the protein level on AD risk is unclear. We assessed the utility of plasma ApoE protein as a potential biomarker of AD in the large, well-characterised Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) cohort.
Methods: Total plasma ApoE levels were measured at 18-month follow-up using a commercial bead-based enzyme-linked immunosorbent assay: the Luminex xMAP human apolipoprotein kit. ApoE levels were then analysed between clinical classifications (healthy controls, mild cognitive impairment (MCI) and AD) and correlated with the data available from the AIBL cohort, including but not limited to APOE genotype and cerebral amyloid burden.
Results: A significant decrease in ApoE levels was found in the AD group compared with the healthy controls. These results validate previously published ApoE protein levels at baseline obtained using different methodology. ApoE protein levels were also significantly affected, depending on APOE genotypes, with ε2/ε2 having the highest protein levels and ε4/ε4 having the lowest. Plasma ApoE levels were significantly negatively correlated with cerebral amyloid burden as measured by neuroimaging.
Conclusions: ApoE is decreased in individuals with AD compared with healthy controls at 18-month follow-up, and this trend is consistent with our results published at baseline. The influence of APOE genotype and sex on the protein levels are also explored. It is clear that ApoE is a strong player in the aetiology of this disease at both the protein and genetic levels
A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle
Current methods to quantify in vivo RNA dynamics are limited. Here, we developed a novel stable isotope (D2O) methodology to quantify RNA synthesis (i.e., ribosomal biogenesis) in cells, animal models, and humans. First, proliferating C2C12 cells were incubated in D2O-enriched media and myotubes ±50 ng/ml IGF-I. Second, rat quadriceps (untrained, n = 9; 7-wk interval-“like” training, n = 13) were collected after ~3-wk D2O (70 atom %) administration, with body-water enrichment monitored via blood sampling. Finally, 10 (23 ± 1 yr) men consumed 150-ml D2O followed by 50 ml/wk and undertook 6-wk resistance exercise (6 × 8 repetitions, 75% 1-repetition maximum 3/wk) with body-water enrichment monitored by saliva sampling and muscle biopsies (for determination of RNA synthesis) at 0, 3, and 6 wk. Ribose mole percent excess (r-MPE) from purine nucleotides was analyzed via GC-MS/MS. Proliferating C2C12 cell r-MPE exhibited a rise to plateau, whereas IGF-I increased myotube RNA from 76 ± 3 to 123 ± 3 ng/μl and r-MPE by 0.39 ± 0.1% (both P < 0.01). After 3 wk, rat quadriceps r-MPE had increased to 0.25 ± 0.01% (P < 0.01) and was greater with running exercise (0.36 ± 0.02%; P < 0.01). Human muscle r-MPE increased to 0.06 ± 0.01 and 0.13 ± 0.02% at 3/6 wk, respectively, equating to synthesis rates of ~0.8%/day, increasing with resistance exercise to 1.7 ± 0.3%/day (P < 0.01) and 1.2 ± 0.1%/day (P < 0.05) at 3/6 wk, respectively. Therefore, we have developed and physiologically validated a novel technique to explore ribosomal biogenesis in a multimodal fashion
Retailing in the United Kingdom - a synopsis
This paper illustrates the structure of, and trends in, the retail market of the United Kingdom (UK). This industry analysis describes the retail environment compared to continental Europe and considers the regulatory issues which have helped form this retail environment. By using secondary data we describe concentration and consolidation tendencies and explain specific features of the UK retail market. Major trends are identified and discussed, concluding with an outlook on future developments
Height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality
OBJECTIVES: Height is inversely associated with cardiovascular disease mortality risk and has shown variable associations with cancer incidence and mortality. The interpretation of findings from previous studies has been constrained by data limitations. Associations between height and specific causes of death were investigated in a large general population cohort of men and women from the West of Scotland.
DESIGN: Prospective observational study.
SETTING: Renfrew and Paisley, in the West of Scotland.
SUBJECTS: 7052 men and 8354 women aged 45-64 were recruited into a study in Renfrew and Paisley, in the West of Scotland, between 1972 and 1976. Detailed assessments of cardiovascular disease risk factors, morbidity and socioeconomic circumstances were made at baseline.
MAIN OUTCOME MEASURES: Deaths during 20 years of follow up classified into specific causes.
RESULTS: Over the follow up period 3347 men and 2638 women died. Height is inversely associated with all cause, coronary heart disease, stroke, and respiratory disease mortality among men and women. Adjustment for socioeconomic position and cardiovascular risk factors had little influence on these associations. Height is strongly associated with forced expiratory volume in one second (FEV1) and adjustment for FEV1 considerably attenuated the association between height and cardiorespiratory mortality. Smoking related cancer mortality is not associated with height. The risk of deaths from cancer unrelated to smoking tended to increase with height, particularly for haematopoietic, colorectal and prostate cancers. Stomach cancer mortality was inversely associated with height. Adjustment for socioeconomic position had little influence on these associations.
CONCLUSION: Height serves partly as an indicator of socioeconomic circumstances and nutritional status in childhood and this may underlie the inverse associations between height and adulthood cardiorespiratory mortality. Much of the association between height and cardiorespiratory mortality was accounted for by lung function, which is also partly determined by exposures acting in childhood. The inverse association between height and stomach cancer mortality probably reflects Helicobacter pylori infection in childhood resulting inor being associated withshorter height. The positive associations between height and several cancers unrelated to smoking could reflect the influence of calorie intake during childhood on the risk of these cancers
Decoherence control in microwave cavities
We present a scheme able to protect the quantum states of a cavity mode
against the decohering effects of photon loss. The scheme preserves quantum
states with a definite parity, and improves previous proposals for decoherence
control in cavities. It is implemented by sending single atoms, one by one,
through the cavity. The atomic state gets first correlated to the photon number
parity. The wrong parity results in an atom in the upper state. The atom in
this state is then used to inject a photon in the mode via adiabatic transfer,
correcting the field parity. By solving numerically the exact master equation
of the system, we show that the protection of simple quantum states could be
experimentally demonstrated using presently available experimental apparatus.Comment: 13 pages, RevTeX, 8 figure
New Insights into White-Light Flare Emission from Radiative-Hydrodynamic Modeling of a Chromospheric Condensation
(abridged) The heating mechanism at high densities during M dwarf flares is
poorly understood. Spectra of M dwarf flares in the optical and
near-ultraviolet wavelength regimes have revealed three continuum components
during the impulsive phase: 1) an energetically dominant blackbody component
with a color temperature of T 10,000 K in the blue-optical, 2) a smaller
amount of Balmer continuum emission in the near-ultraviolet at lambda 3646
Angstroms and 3) an apparent pseudo-continuum of blended high-order Balmer
lines. These properties are not reproduced by models that employ a typical
"solar-type" flare heating level in nonthermal electrons, and therefore our
understanding of these spectra is limited to a phenomenological interpretation.
We present a new 1D radiative-hydrodynamic model of an M dwarf flare from
precipitating nonthermal electrons with a large energy flux of erg
cm s. The simulation produces bright continuum emission from a
dense, hot chromospheric condensation. For the first time, the observed color
temperature and Balmer jump ratio are produced self-consistently in a
radiative-hydrodynamic flare model. We find that a T 10,000 K
blackbody-like continuum component and a small Balmer jump ratio result from
optically thick Balmer and Paschen recombination radiation, and thus the
properties of the flux spectrum are caused by blue light escaping over a larger
physical depth range compared to red and near-ultraviolet light. To model the
near-ultraviolet pseudo-continuum previously attributed to overlapping Balmer
lines, we include the extra Balmer continuum opacity from Landau-Zener
transitions that result from merged, high order energy levels of hydrogen in a
dense, partially ionized atmosphere. This reveals a new diagnostic of ambient
charge density in the densest regions of the atmosphere that are heated during
dMe and solar flares.Comment: 50 pages, 2 tables, 13 figures. Accepted for publication in the Solar
Physics Topical Issue, "Solar and Stellar Flares". Version 2 (June 22, 2015):
updated to include comments by Guest Editor. The final publication is
available at Springer via http://dx.doi.org/10.1007/s11207-015-0708-
Charge-Symmetry Violation in Pion Scattering from Three-Body Nuclei
We discuss the experimental and theoretical status of charge-symmetry
violation (CSV) in the elastic scattering of pi+ and pi- on 3H and 3He.
Analysis of the experimental data for the ratios r1, r2, and R at Tpi = 142,
180, 220, and 256 MeV provides evidence for the presence of CSV. We describe
pion scattering from the three-nucleon system in terms of single- and
double-scattering amplitudes. External and internal Coulomb interactions as
well as the Delta-mass splitting are taken into account as sources of CSV.
Reasonable agreement between our theoretical calculations and the experimental
data is obtained for Tpi = 180, 220, and 256 MeV. For these energies, it is
found that the Delta-mass splitting and the internal Coulomb interaction are
the most important contributions for CSV in the three-nucleon system. The CSV
effects are rather sensitive to the choice of pion-nuclear scattering
mechanisms, but at the same time, our theoretical predictions are much less
sensitive to the choice of the nuclear wave function. It is found, however,
that data for r2 and R at Tpi = 142 MeV do not agree with the predictions of
our model, which may indicate that there are additional mechanisms for CSV
which are important only at lower energies.Comment: 26 pages of RevTeX, 16 postscript figure
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