Lost Memories, Lost Colonies

The Roanoke Colony was the first English colony in America. The colonists were abandonded by the Governor shortly after the colony was established. In public memory, the fate of the colony is highly debated and has since become an American founding myth. As a result of the contested fate, the story of Roanoke has since become a blank slate upon which other legends can evolve. These legends become a window for historians into the insecurities of those who created them. This paper discusses why the English wanted to establish a colony, the popularization of Pocahontas, the history of marriages between Europeans and Native Americans in America, The Lost Colony play by Paul Green, and recent popluar culture pieces that mention Roanoke. Each part of the evolution of this story holds meaning about the time in which it originated. Roanoke simply serves as the vessel through which we come to understandings about public memory and the history of mixed marriages in America. Keywords: Lost Colony, Roanoke, memory, Native Americans, Outer Banks, marriag

Comparison of Hamstring and Quadriceps Muscle Activity in Men and Women Performing a Body Weight Squat

Multiple studies support the idea that women use a more quadriceps dominant activation pattern at the knee during stabilizing movements which may predispose them to a greater risk of ACL injury. A body weight squat is a common exercise used to strengthen knee musculature in attempt to minimize the risk of ACL injury. However, it is not clear whether this exercise activates the knee musculature in a manner that would not exacerbate the quadriceps dominance often observed in women. PURPOSE: To determine if women are more quadriceps dominant than men when performing a two-legged body weight squat. METHODS: Seven male and seven female Division III collegiate athletes (20.5±1.0 yrs, 176.2± 12.6 cm, and 79.7± 16.6 kg) provided informed consent and participated in this study. Surface EMG collected at 1000 Hz was used to measure the muscle activity of the vastus lateralis (VL) and the biceps femoris (BF), and normalized to the respective maximum voluntary isometric contraction (MVIC) for each muscle. Participants performed eight repetitions of a two-legged body weight squat at a cadence of 54 bpm. RMS EMG was computed across a 200 ms window and analyzed for the middle six repetitions at 15°, 45° and 60° of knee flexion during the movement. Hamstrings and quadriceps activity for the concentric phase of movement were evaluated separately, with two 2x3 (gender x joint position) mixed model ANOVAs. RESULTS: No interaction was observed between gender and joint position for either quadriceps (F(1,11) = 0.64, p = 0.54) or hamstring activity (F(1,11) = 1.24, p = .31). As knee flexion decreased, both quadriceps and hamstrings activity significantly decreased. Quadriceps activity, decreased from 41.7± 24.9%MVIC at 60° to 37.6± 21.7% at 45° to 34.2± 22.7% at 15° (F(1,11) = 5.74, p = 0.01). Likewise, hamstring activity decreased from 26.7± 28.9%MVIC at 60° to 20.6± 20.6% at 45° and to 18.2± 19.1% at 15° (F(1,11) = 3.92, p = 0.04). CONCLUSION: Gender-specific muscular imbalances do not occur during the performance of a bodyweight squat suggesting that such an exercise is appropriate as a part of strength training program designed to reduce ACL risk in women. However, knee angle is a relevant factor to consider when examining muscular characteristics of dynamic movements and injury mechanisms

"Basal conditions of Kongsvegen at the onset of surge - revealed using seismic vibroseis surveys" in the IASC Workshop on the dynamics and mass budget of Arctic glaciers - Abstracts and program booklet.

Kongsvegen is a well-studied surge-type glacier in the Kongsfjord area of northwest Svalbard. Long-term monitoring has shown that the ice surface velocity has been increasing for the past 4 years; presenting a unique opportunity to study the internal ice structure, basal conditions and thermal regime that play a crucial role in initiating glacier surges. In April 2019, three-component seismic vibroseis surveys were conducted at two sites on the glacier, using a small Electrodynamic Vibrator source (ElViS). Site 1 is in the ablation area and site 2 near the equilibrium line, where the greatest increase in ice surface velocity has been observed. Initial analysis indicates the conditions at the two sites are significantly different. At site 1 the ice is around 220 m thick, sitting on a relatively flat and uniform bed, with no clear change in the bed reflection along the profile. There is a horizontally layered sediment package ∼60 m thick underlaying the bed. The ice column shows no internal layering. By contrast at site 2 (Fig. 1), where the ice is around 390 m thick, there is much more complex internal ice structure. Clear internal ice reflections are visible between 150-250 m depth – where we expect a transition from cold to temperate ice. Further reflections in the 100 m above the bed indicate there could be shearing or sediment entrainment in this area. Below the bed, cross-cutting layers are clearly visible and the bed reflection itself shows changing reflection polarity – suggesting water or very wet sediment is present in some areas. This suggests ice movement by basal sliding and shearing is likely

Sediment features at the grounding zone and beneath Ekström Ice Shelf, East Antarctica, imaged using on-ice vibroseis

The grounding zone, where an ice sheet becomes a floating ice shelf, is known to be a key threshold region for ice flow and stability. A better understanding of ice dynamics and sediment transport across such zones will improve knowledge about contemporary and palaeo ice flow, as well as past ice extent. Here we present a set of seismic reflection profiles crossing the grounding zone and continuing to the shelf edge of Ekström Ice Shelf, East Antarctica. Using an on-ice vibroseis source combined with a snowstreamer we have imaged a range of sub-glacial and sub-shelf sedimentary and geomorphological features; from layered sediment deposits to elongated flow features. The acoustic properties of the features as well as their morphology allow us to draw conclusions as to their material properties and origin. These results will eventually be integrated with numerical models of ice dynamics to quantify past and present interactions between ice and the solid Earth in East Antarctica; leading to a better understanding of future contributions of this region to sea-level rise

Body Image in Primary Schools: A pilot evaluation of a primary school intervention program designed by teachers to improve children's body satisfaction

© 2016 Body Image in the Primary School (Hutchinson & Calland, 2011) is a body image curriculum that is widely available but has not yet been evaluated. This study evaluates a set of 6 of the 49 available lessons from this curriculum. Seventy-four girls and 70 boys aged 9–10 were recruited from four primary schools in the UK. Schools were randomly allocated into the intervention condition, where students received 6hours of body image lessons, or to lessons as normal. Body esteem was significantly higher among girls in the intervention group, compared to the control group, immediately post intervention, and at 3-month follow-up. Moreover, girls with lowest levels of body esteem at baseline reported the largest gains. Internalization was significantly lower among boys in the control group compared to the intervention group at 3-month follow-up. The pattern of results among the control group raises interesting issues for intervention evaluation

Stigma as a fundamental hindrance to the United States opioid overdose crisis response.

Alexander Tsai and co-authors discuss the role of stigma in responses to the US opioid crisis

The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila

<p>Abstract</p> <p>Background</p> <p>Mammalian <it>Delta-like 1 </it>(<it>Dlk-1</it>) protein shares homology with Notch ligands but lacks a critical receptor-binding domain. Thus it is unclear whether it is able to interact with Notch <it>in vivo</it>. Unlike mammals, <it>Drosophila </it>have a single Notch receptor allowing a simple <it>in vivo </it>assay for mammalian <it>Dlk1 </it>function.</p> <p>Results</p> <p>Here we show that membrane-bound DLK1 can regulate Notch leading to altered cellular distribution of Notch itself and inhibiting expression of Notch target genes. The resulting adult phenotypes are indicative of reduced Notch function and are enhanced by <it>Notch </it>mutations, confirming that DLK1 action is antagonistic. In addition, cells expressing an alternative <it>Dlk1 </it>isoform exhibit alterations in cell size, functions previously not attributed to Notch suggesting that DLK1 might also act via an alternative target.</p> <p>Conclusion</p> <p>Our results demonstrate that DLK1 can regulate the Notch receptor despite its atypical structure.</p

Off-World Mental Health:Considerations for the Design of Well-being-Supportive Technologies for Deep Space Exploration

During future long-duration space exploration missions, humans will be exposed to combinations of extreme physical, psychological, and interpersonal demands. These demands create risks for the safety, performance, health, and well-being of both individuals and crew. The communication latency in deep space means that explorers will increasingly have to operate independently and take responsibility for their own self-care and self-management. At present, several research programs are focused on developing and testing digital technologies and countermeasures that support the effective functioning of deep space crews. Although promising, these initiatives have been stimulated mostly by technological opportunity rather than cogent theory. In this perspective, we argue that digital technologies developed for spaceflight should be informed by well-being–supportive design principles and be cognizant of broader conversations around the development and use of digital health applications, especially pertaining to issues of autonomy, privacy, and trust. These issues are important for designing potentially mission-critical health technologies and may be determining factors in the safe and successful completion of future off-world endeavors.publishedVersio

Differences in level of confidence in diabetes care between different groups of trainees: the TOPDOC diabetes study

Background There is an increasing prevalence of diabetes. Doctors in training, irrespective of specialty, will have patients with diabetes under their care. The aim of this further evaluation of the TOPDOC Diabetes Study data was to identify if there was any variation in confidence in managing diabetes depending on the geographical location of trainees and career aspirations. Methods An online national survey using a pre-validated questionnaire was administered to trainee doctors. A 4-point confidence rating scale was used to rate confidence in managing aspects of diabetes care and a 6-point scale used to quantify how often trainees would contribute to the management of patients with diabetes. Responses were grouped depending on which UK country trainees were based and their intended career choice. Results Trainees in Northern Ireland reported being less confident in IGT diagnosis, use of IV insulin and peri-operative management and were less likely to adjust oral treatment, contact specialist, educate lifestyle, and optimise treatment. Trainees in Scotland were less likely to contact a specialist, but more likely to educate on lifestyle, change insulin, and offer follow-up advice. In Northern Ireland, Undergraduate (UG) and Postgraduate (PG) training in diagnosis was felt less adequate, PG training in emergencies less adequate, and reporting of need for further training higher. Trainees in Wales felt UG training to be inadequate. In Scotland more trainees felt UG training in diagnosis and optimising treatment was inadequate. Physicians were more likely to report confidence in managing patients with diabetes and to engage in different aspects of diabetes care. Aspiring physicians were less likely to feel the need for more training in diabetes care; however a clear majority still felt they needed more training in all aspects of care. Conclusions Doctors in training have poor confidence levels dealing with diabetes related care issues. Although there is variability between different groups of trainees according to geographical location and career aspirations, this is a UK wide issue. There should be a UK wide standardised approach to improving training for junior doctors in diabetes care with local training guided by specific needs.</p