The Middle Ages goes global: Henri Pirenne, his thesis, and medieval globalities past and present

Scholarships & Prizes Office. University of Sydne

‘Le monde est un logement d'étrangers’: François Savary de Brèves (1560–1628), diplomatic agent in the early modern Mediterranean

François Savary de Brèves (1560–1628) served as French ambassador to the Ottoman Empire from 1592 to 1606 and, together with his earlier attachment to the French embassy, spent close to two decades in the Ottoman capital. It was the longest sojourn of any French ambassador since the French entered into formal diplomatic relations with the Ottomans in 1535. Despite scholars crediting his term as a watershed moment in Ottoman-French relations, a complete study on him remains to be published. Savary de Brèves also established the first press in Paris for printing in Arabic, Persian and Turkish, just one component of a broader vision of oriental studies in early modern France whose motivations have remained ambiguous for scholars to-date. Examining his diplomatic career and oriental studies project within the context of a complex cross-cultural, multi-lingual Mediterranean at the turn of the seventeenth century, this study argues Savary de Brèves represents a new kind of agent who was instrumental in redefining European attitudes towards the Ottomans, in fields including diplomacy, language and oriental studies, in response to pragmatic geopolitical realities. This study has implications for the way we think about diplomacy, language-learning, oriental studies and the Mediterranean in the early modern period, particularly in the often-overlooked period of the early seventeenth century. The study draws on a variety of sources produced by Savary de Brèves, including diplomatic correspondence, Ottoman legal and administrative sources, the travel account of his journey to Tunis and Algiers, and his writings about the Ottomans in his later years

Investigation into the effects of transmission-channel fidelity loss in RGBD sensor data for SLAM

Simultaneous Location and Mapping (SLAM) is computationally expensive, and requires high-fidelity sensor data. This paper investigates the effects of transmission channel fidelity loss in Red-Green-Blue-Depth (RGBD) sensor data. A mobile robotic platform developed for Explosive Ordinance Disposal (EOD) is used, with a highly constrained data and video link to a base station which computes a SLAM solution. Experiments were conducted offline, using well known data-sets with ground truth data, and their results have been compared to determine the effect of fidelity loss under various multiplexing approaches with a constrained transmission channel

An integrated national scale SARS-CoV-2 genomic surveillance network.

The Coronavirus Disease 2019 (COVID-19) Genomics UK Consortium (COG-UK) was launched in March, 2020, with £20 million support from UK Research and Innovation, the UK Department of Health and Social Care, and Wellcome Trust. The goal of this consortium is to sequence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for up to 230 000 patients, health-care workers, and other essential workers in the UK with COVID-19, which will help to enable the tracking of SARS-CoV-2 transmission, identify viral mutations, and integrate with health data to assess how the viral genome interacts with cofactors and consequences of COVID-19

Afoxolaner as a Treatment for a Novel Sarcoptes scabiei Infestation in a Juvenile Potbelly Pig

A 2 months old female Vietnamese potbellied pig presented to a veterinary teaching hospital with a referring complaint of pruritus. A human caretaker of the pig had recently been diagnosed with a Sarcoptes spp. dermatitis. Microscopic examination of the skin scrape samples and BLAST analysis confirmed the species of the mite as most closely related to Sarcoptes scabiei var. canis (AY493391). The pig was treated with afoxolaner as previous treatment with ivermectin was not efficacious. Recheck examinations and follow up revealed the pig to be non-pruritic and resolving. Afoxolaner may be a therapeutic option when treating Sarcoptes spp. infections in companion pigs

The dark energy spectrometer - A potential multi-fiber instrument for the Blanco 4-meter telescope

We describe the preliminary design of the Dark Energy Spectrometer (DESpec), a fiber-fed spectroscopic instrument concept for the Blanco 4-meter telescope at Cerro Tololo Inter-American Observatory (CTIO). DESpec would take advantage of the infrastructure recently deployed for the Dark Energy Camera (DECam). DESpec would be mounted in the new DECam prime focus cage, would be interchangeable with DECam, would share the DECam optical corrector, and would feature a focal plane with ∼4000 robotically positioned optical fibers feeding multiple high-throughput spectrometers. The instrument would have a field of view of 3.8 square degrees, a wavelength range of approximately 500<λ<1000 nm, and a spectral resolution of R∼3000. DESpec would provide a powerful spectroscopic follow-up system for sources in the Southern hemisphere discovered by the Dark Energy Survey and LSST

Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020–December 2021

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population

The longer-term effects of access to HIV self-tests on HIV testing frequency in high-risk gay and bisexual men: follow-up data from a randomised controlled trial

Background: A wait-list randomised controlled trial in Australia (FORTH) in high-risk gay and bisexual men (GBM) showed access to free HIV self-tests (HIVSTs) doubled the frequency of HIV testing in year 1 to reach guideline recommended levels of 4 tests per year, compared to two tests per year in the standard-care arm (facility-based testing). In year 2, men in both arms had access to HIVSTs. We assessed if the effect was maintained for a further 12 months. Methods: Participants included GBM reporting condomless anal intercourse or > 5 male partners in the past 3 months. We included men who had completed at least one survey in both year 1 and 2 and calculated the mean tests per person, based on the validated self-report and clinic records. We used Poisson regression and random effects Poisson regression models to compare the overall testing frequency by study arm, year and testing modality (HIVST/facility-based test). Findings: Overall, 362 men completed at least one survey in year 1 and 343 in year 2. Among men in the intervention arm (access to HIVSTs in both years), the mean number of HIV tests in year 2 (3⋅7 overall, 2⋅3 facility-based tests, 1⋅4 HIVSTs) was lower compared to year 1 (4⋅1 overall, 1⋅7 facility-based tests, 2⋅4 HIVSTs) (RR:0⋅84, 95% CI:0⋅75-0⋅95, p=0⋅002), but higher than the standard-care arm in year 1 (2⋅0 overall, RR:1⋅71, 95% CI:1⋅48-1.97, p<0⋅001). Findings were not different when stratified by sociodemographic characteristics or recent high risk sexual history. Interpretation: In year 2, fewer HIVSTs were used on average compared to year 1, but access to free HIVSTs enabled more men to maintain higher HIV testing frequency, compared with facility-based testing only. HIV self-testing should be a key component of HIV testing and prevention strategies. Funding:: This work was supported by grant 568971 from the National Health and Medical Research Council of Australia