11 research outputs found
Improved markers of cholestatic liver injury in patients with primary biliary cholangitis treated with obeticholic acid and bezafibrate.
A decrease or normalization of alkaline phosphatase (ALP) and bilirubin levels in patients treated for primary biliary cholangitis (PBC) predicts a better survival. Obeticholic acid (OCA) is the approved second-line therapy if ursodeoxycholic acid (UCDA) fails, but its use may worsen pruritus. Adding bezafibrate to UCDA improved biochemical markers of cholestatic liver injury and decreased pruritus severity. Because normalization of ALP and bilirubin was only achieved in a minority of patients in these studies, we explored whether bezafibrate (off-label drug) could improve the effect of OCA (licensed drug) on cholestasis.status: Published onlin
Depicting the Landscape of Adipose Tissue-Specific Macrophages and Their Immunometabolic Signatures during Obesity
Obesity is a widespread health condition, which can lead to the development of metabolic disorders, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular diseases. Obesity is marked by the excessive deposition of fat in adipose tissue sites combined with chronic low-grade inflammation. Within this clinical setting, it is well established that adipose tissue macrophages exhibit prominent roles in regulating inflammation and metabolism. However, aside from these well-established roles, the involvement of microenvironmental cues as well as underlying cellular metabolism in driving immunological fate decisions within macrophages are poorly understood. Here we aim to map the different adipose tissue-derived macrophage subsets, together with their metabolic and functional profiles. Finally, we discuss their potential contribution during homeostasis and disease progression associated with obesity.status: publishe
Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial
Forecasting the UK economy: Alternative forecasting methodologies and the role of off-model information
Combination of Fibrates with Obeticholic Acid Is Able to Normalise Biochemical Liver Tests in Patients with Difficult-to-treat Primary Biliary Cholangitis
International audienc