Best Practice In Company Standardisation

Though the majority of standards are company standards, scientificstandardisation literature pays hardly any attention to them. In thispaper we describe results from a research project on companystandardisation (Oly & Slob, 1999). The researchers investigated sixchemical and petrochemical industries in the Netherlands: Akzo Nobel,Dow Chemical, DSM, Gasunie, NAM and Shell. These companies havenumerous standards for their installations. Best practice fordeveloping such standards was developed by examining the companies andusing insights from relevant literature. This paper describes thescientific approach used and some of the best practice results.benchmarking;standard;standardization;company standardization;process industry

Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.

There is growing interest in quantitative analysis of in vivo genetic toxicity dose-response data, and use of point-of-departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic rodent (TGR) assay variants, employing different rodent strains and reporter transgenes, are used for the assessment of chemically-induced genotoxic effects in vivo. However, regulatory issues arise when different PoD values (e.g., lower BMD confidence intervals or BMDLs) are obtained for the same compound across different TGR assay variants. This study therefore employed the BMD approach to examine the ability of different TGR variants to yield comparable genotoxic potency estimates. Review of over 2000 dose-response datasets identified suitably-matched dose-response data for three compounds (ethyl methanesulfonate or EMS, N-ethyl-N-nitrosourea or ENU, and dimethylnitrosamine or DMN) across four commonly-used murine TGR variants (Muta™Mouse lacZ, Muta™Mouse cII, gpt delta and BigBlue® lacI). Dose-response analyses provided no conclusive evidence that TGR variant choice significantly influences the derived genotoxic potency estimate. This conclusion was reliant upon taking into account the importance of comparing BMD confidence intervals as opposed to directly comparing PoD values (e.g., comparing BMDLs). Comparisons with earlier works suggested that with respect to potency determination, tissue choice is potentially more important than choice of TGR assay variant. Scoring multiple tissues selected on the basis of supporting toxicokinetic information is therefore recommended. Finally, we used typical within-group variances to estimate preliminary endpoint-specific benchmark response (BMR) values across several TGR variants/tissues. We discuss why such values are required for routine use of genetic toxicity PoDs for HHRA. Environ. Mol. Mutagen. 58:632-643, 2017. © 2017 Her Majesty the Queen in Right of Canada. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc

The Voice of the Other: A Dialogico-Rhetorical Understanding of Opponent and Toulmin’s Rebuttal

Although contemporary dialectical logic recognizes an important role for the opponent in argumentation, it remains loyal to the idea that arguments are supportive. In this paper, it is argued that because of this dialectical logic does not take seriously its own dialogical perspective. Without acknowledging a substantial role for rebutting factors in argumentation, the role of the opponent remains secondary. Toulmin’s understanding of the rebuttal suggests a way to incorporate such a substantial role of the opponent

But that simply isn\u27t true; rethinking truth in argumentation

Since the dialectical turn in logic, truth has been replaced by acceptability. The latter notion, however, does not provide for a strong enough constraint. It is thought that only truth can overrule acceptability, and for that reason we need to reass ess the notion. Still, truth is a confusing philosophical concept, and we should be clear as to which understanding of the notion can do the job. I shall argue that a correspondence theory of truth in particular will not do. Rather we should adopt a de flationary account: all we need is a suitable understanding of the truth-predicate

The PRIMO FORTE framework for good governance in public, private and civic organisations : an analysis on small EU states

Purpose: In this article we lay out and discuss a framework proposed by the Public Risk Management Organisation (PRIMO) (https://www.primo-europe.eu/) of which the authors are board members and the results of a test on public and private entities of EU small jurisdictions, specifically Malta, Slovenia, Luxembourg, Lithuania, Latvia, Estonia and Cyprus. These are countries within the EU having less than 3 million people population. Design/methodology/approach: We collected our primary data by using a semi-structured questionnaire and administering it to participants who are working directly or indirectly with entities within these EU states. The questionnaire was structured using the FORTETM acronym as themes, ‘Financial and compliant design’, ‘Object orientation and delivery’, ‘Responsibility and stewardship’, ‘Tools and processes for creation’ and ‘Environmental awareness and interaction’, with 5 statements under each theme to which participants were required to answer using a 5-point Likert-scale ranging from “Strongly Disagree” to “Strongly Agree”. We, however, allowed the participants to open up and discuss each statement and recorded these comments. Some demographic data was also collected as to the type of entity the participants are working with, the level of expertise on governance of the participant and the size of the entity. The quantitative data was subjected to statistical analysis while the results from the open ended question was analysed using the Thematic approach. Findings: Factor analysis provided support for the FORTE Good Governance model for both the Private and Public entities, no-matter if they are small or large. Originality/value: The study provides a better understanding and supports the FORTE Model established by PRIMO-Europe, after approximately 15 years of collecting data on public risks and for the first time tests it on both Private and Public entities, in large and small firms in small EU Jurisdictions. Moreover, this model contributed to the vast literature on models of risk management within organisations, but was not validated empirically for reliability of the factors, and on small jurisdictions. Therefore, the significance and importance of such a study lies firstly on the premise that testing on small countries, can be deemed as small laboratories for more complex politics, regulations and policies of larger countries.peer-reviewe