Diammonium tris­[hexa­aqua­magnesium(II)] tetra­kis­[hydrogenphosphate(III)], (NH4)2[Mg(H2O)6]3(HPO3)4

The framework of the title compound is made up of discrete Mg(H2O)6 octa¬hedra, and HPO3 and NH4 tetra¬hedra, which are organized in planes parallel to (010). Strong hydrogen bonding between the building units stabilizes the structure. The hydrogenphosphate(III) tetra¬hedra, the ammonium tetra¬hedron and one of the two Mg atoms lie on positions with m symmetry, whereas the second Mg atom is located on a position with 2/m symmetry

The space–time-fractional derivatives order effect of Caputo–Fabrizio on the doping profiles for formation a p-n junction

In this study, we treated the space–time-fractional diffusion equation in a semi-infinite medium using a recently developed fractional derivative introduced by Caputo and Fabrizio. Our main focus was on simulating the diffusion profiles during the creation of a p-n junction according to the obtained solution. We made an interesting observation regarding the influence of the fractional-order derivatives on the depth estimation of the p-n junction. Increasing the order of the time-fractional derivative, denoted as $$\alpha$$, resulted in faster diffusion and deeper p-n junctions. On the other hand, increasing the order of the space fractional derivative, denoted as $$\beta$$, led to slower diffusion and shallower p-n junctions. These findings demonstrate the significant impact of the fractional derivative orders on the diffusion behavior and depth characteristics of the p-n junction in the studied system

Diammonium tris­[hexa­aqua­magnesium(II)] tetra­kis­[hydrogenphosphate(III)], (NH4)2[Mg(H2O)6]3(HPO3)4

The framework of the title compound is made up of discrete Mg(H2O)6 octa¬hedra, and HPO3 and NH4 tetra¬hedra, which are organized in planes parallel to (010). Strong hydrogen bonding between the building units stabilizes the structure. The hydrogenphosphate(III) tetra¬hedra, the ammonium tetra¬hedron and one of the two Mg atoms lie on positions with m symmetry, whereas the second Mg atom is located on a position with 2/m symmetry

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old