61 research outputs found
High-frequency nanotube mechanical resonators
We report on a simple method to fabricate high-frequency nanotube mechanical
resonators reproducibly. We measure resonance frequencies as high as 4.2 GHz
for the fundamental eigenmode and 11 GHz for higher order eigenmodes. The
high-frequency resonances are achieved using short suspended nanotubes and by
introducing tensile stress in the nanotube. These devices allow us to determine
the coefficient of the thermal expansion of an individual nanotube, which is
negative and is about -0.7E-5 1/K at room temperature. High-frequency
resonators made of nanotubes hold promise for mass sensing and experiments in
the quantum limit
Mechanical oscillations in lasing microspheres
We investigate the feasibility of activating coherent mechanical oscillations
in lasing microspheres by modulating the laser emission at a mechanical
eigenfrequency. To this aim, 1.5% Nd3+:Barium-Titanium-Silicate microspheres
with diameters around 50 {\mu}m were used as high quality factor (Q>10^6)
whispering gallery mode lasing cavities. We have implemented a pump-and-probe
technique in which the pump laser used to excite the Nd3+ ions is focused on a
single microsphere with a microscope objective and a probe laser excites a
specific optical mode with the evanescent field of a tapered fibre. The studied
microspheres show monomode and multi-mode lasing action, which can be modulated
in the best case up to 10 MHz. We have optically transduced thermally-activated
mechanical eigenmodes appearing in the 50-70 MHz range, the frequency of which
decreases with increasing the size of the microspheres. In a pump-and-probe
configuration we observed modulation of the probe signal up to the maximum pump
modulation frequency of our experimental setup, i.e., 20 MHz. This modulation
decreases with frequency and is unrelated to lasing emission, pump scattering
or thermal effects. We associate this effect to free-carrier-dispersion induced
by multiphoton pump light absorption. On the other hand, we conclude that, in
our current experimental conditions, it was not possible to resonantly excite
the mechanical modes. Finally, we discuss on how to overcome these limitations
by increasing the modulation frequency of the lasing emission and decreasing
the frequency of the mechanical eigenmodes displaying a strong degree of
optomechanical coupling.Comment: 17 pages, 5 figure
Thermal transport in nanoporous holey silicon membranes investigated with optically-induced transient thermal gratings
In this study, we use the transient thermal grating optical technique
\textemdash a non-contact, laser-based thermal metrology technique with
intrinsically high accuracy \textemdash to investigate room-temperature
phonon-mediated thermal transport in two nanoporous holey silicon membranes
with limiting dimensions of 100 nm and 250 nm respectively. We compare the
experimental results to ab initio calculations of phonon-mediated thermal
transport according to the phonon Boltzmann transport equation (BTE) using two
different computational techniques. We find that the calculations conducted
within the Casimir framework, i.e. based on the BTE with the bulk phonon
dispersion and diffuse scattering from surfaces, are in quantitative agreement
with the experimental data, and thus conclude that this framework is adequate
for describing phonon-mediated thermal transport through holey silicon
membranes with feature sizes on the order of 100 nm
Thermal transport in nanoporous holey silicon membranes investigated with optically induced transient thermal gratings
In this study, we use transient thermal gratings—a non-contact, laser-based thermal metrology technique with intrinsically high accuracy—to investigate room-temperature phonon-mediated thermal transport in two nanoporous holey silicon membranes with limiting dimensions of 120 nm and 250 nm, respectively. We compare the experimental results with ab initio calculations of phonon-mediated thermal transport according to the phonon Boltzmann transport equation (BTE) using two different computational techniques. We find that the calculations conducted within the Casimir framework, i.e., based on the BTE with the bulk phonon dispersion and diffuse scattering from surfaces, are in quantitative agreement with the experimental data and thus conclude that this framework is adequate for describing phonon-mediated thermal transport in silicon nanostructures with feature sizes of the order of 100 nm
Mechanical oscillations in lasing microspheres
We investigate the feasibility of activating coherent mechanical oscillations in lasing microspheres by modulating the laser emission at a mechanical eigenfrequency. To this aim, 1.5%Nd3+:Barium-Titanium-Silicate microspheres with diameters around 50 μm were used as high quality factor (Q>106) whispering gallery mode lasing cavities. We have implemented a pump-and-probe technique in which the pump laser used to excite the Nd3+ ions is focused on a single microsphere with a microscope objective and a probe laser excites a specific optical mode with the evanescent field of a tapered fibre. The studied microspheres show monomode and multi-mode lasing action, which can be modulated in the best case up to 10 MHz. We have optically transduced thermally-activated mechanical eigenmodes appearing in the 50-70 MHz range, the frequency of which decreases with increasing the size of the microspheres. In a pump-and-probe configuration we observed modulation of the probe signal up to the maximum pump modulation frequency of our experimental setup, i.e., 20 MHz. This modulation decreases with frequency and is unrelated to lasing emission, pump scattering or thermal effects. We associate this effect to free-carrier-dispersion induced by multiphoton pump light absorption. On the other hand, we conclude that, in our current experimental conditions, it was not possible to resonantly excite the mechanical modes. Finally, we discuss on how to overcome these limitations by increasing the modulation frequency of the lasing emission and decreasing the frequency of the mechanical eigenmodes displaying a strong degree of optomechanical coupling
TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors
Despite the promising efficacy of adoptive cell therapies (ACT) in melanoma, complete response rates remain relatively low and outcomes in other cancers are less impressive. The immunosuppressive nature of the tumor microenvironment and the expression of immune-inhibitory ligands, such as PD-L1/CD274 by the tumor and stroma are considered key factors limiting efficacy. The addition of checkpoint inhibitors (CPI) to ACT protocols bypasses some mechanisms of immunosuppression, but associated toxicities remain a significant concern. To overcome PD-L1–mediated immunosuppression and reduce CPI-associated toxicities, we used TALEN technology to render tumor-reactive T cells resistant to PD-1 signaling. Here, we demonstrate that inactivation of the PD-1 gene in melanoma-reactive CD8+ T cells and in fibrosarcoma-reactive polyclonal T cells enhanced the persistence of PD-1 gene-modified T cells at the tumor site and increased tumor control. These results illustrate the feasibility and potency of approaches incorporating advanced gene-editing technologies into ACT protocols to silence immune checkpoints as a strategy to overcome locally active immune escape pathways
High field level crossing studies on spin dimers in the low dimensional quantum spin system NaT(CO)(HO) with T=Ni,Co,Fe,Mn
In this paper we demonstrate the application of high magnetic fields to study
the magnetic properties of low dimensional spin systems. We present a case
study on the series of 2-leg spin-ladder compounds
NaT(CO)(HO) with T = Ni, Co, Fe and Mn. In all
compounds the transition metal is in the high spin configuation. The
localized spin varies from S=1 to 3/2, 2 and 5/2 within this series. The
magnetic properties were examined experimentally by magnetic susceptibility,
pulsed high field magnetization and specific heat measurements. The data are
analysed using a spin hamiltonian description. Although the transition metal
ions form structurally a 2-leg ladder, an isolated dimer model consistently
describes the observations very well. This behaviour can be understood in terms
of the different coordination and superexchange angles of the oxalate ligands
along the rungs and legs of the 2-leg spin ladder. All compounds exhibit
magnetic field driven ground state changes which at very low temperatures lead
to a multistep behaviour in the magnetization curves. In the Co and Fe
compounds a strong axial anisotropy induced by the orbital magnetism leads to a
nearly degenerate ground state and a strongly reduced critical field. We find a
monotonous decrease of the intradimer magnetic exchange if the spin quantum
number is increased
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