11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test

Objective 11-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids in vivo, respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 -HSD1 in animal tests. Methods We assessed 11 -HSD1 knockout mice in the forced swim test (FST), tail suspension test (TST) and for locomotor activity. Results Genetic ablation of the 11-HSD1 gene results in an antidepressant-like phenotype in the FST; the most widely utilised animal test of antidepressant activity, but not in the related TST. This may be related to the different biological substrates underlying these tests. The decreased FST immobility was not due to alterations in general activity. Conclusions Taken together these results suggest that 11-HSD1 may play an important role in depression-related behaviours and further studies are necessary to fully characterise its role in such behaviour

The Quark-Gluon-Plasma Liquid

The quark-gluon plasma close to the critical temperature is a strongly interacting system. Using strongly coupled, classical, non-relativistic plasmas as an analogy, we argue that the quark-gluon plasma is in the liquid phase. This allows to understand experimental observations in ultrarelativistic heavy-ion collisions and to interpret lattice QCD results. It also supports the indications of the presence of a strongly coupled QGP in ultrarelativistic heavy-ion collisions.Comment: 8 pages, 2 figures, final version, to bepublished in J. Phys.

Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules

The subdivision of cell populations in compartments is a key event during animal development. In Drosophila, the gene apterous (ap) divides the wing imaginal disc in dorsal vs ventral cell lineages and is required for wing formation. ap function as a dorsal selector gene has been extensively studied. However, the regulation of its expression during wing development is poorly understood. In this study, we analyzed ap transcriptional regulation at the endogenous locus and identified three cis-regulatory modules (CRMs) essential for wing development. Only when the three CRMs are combined, robust ap expression is obtained. In addition, we genetically and molecularly analyzed the trans-factors that regulate these CRMs. Our results propose a three-step mechanism for the cell lineage compartment expression of ap that includes initial activation, positive autoregulation and Trithorax-mediated maintenance through separable CRMsThis study was supported by a grant from the MINECO to CE (No. BFU2012-34353) and grants from the Kantons Basel-Stadt and Basel-Land, and the Swiss National Science Foundation to MA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip

kt Effects in Direct-Photon Production

We discuss the phenomenology of initial-state parton-kt broadening in direct-photon production and related processes in hadron collisions. After a brief summary of the theoretical basis for a Gaussian-smearing approach, we present a systematic study of recent results on fixed-target and collider direct-photon production, using complementary data on diphoton and pion production to provide empirical guidance on the required amount of kt broadening. This approach provides a consistent description of the observed pattern of deviation of next-to-leading order QCD calculations relative to the direct-photon data, and accounts for the shape and normalization difference between fixed-order perturbative calculations and the data. We also discuss the uncertainties in this phenomenological approach, the implications of these results on the extraction of the gluon distribution of the nucleon, and the comparison of our findings to recent related work.Comment: LaTeX, uses revtex and epsf, 37 pages, 15 figure

Corridors of barchan dunes: stability and size selection

Barchans are crescentic dunes propagating on a solid ground. They form dune fields in the shape of elongated corridors in which the size and spacing between dunes are rather well selected. We show that even very realistic models for solitary dunes do not reproduce these corridors. Instead, two instabilities take place. First, barchans receive a sand flux at their back proportional to their width while the sand escapes only from their horns. Large dunes proportionally capture more than they loose sand, while the situation is reversed for small ones: therefore, solitary dunes cannot remain in a steady state. Second, the propagation speed of dunes decreases with the size of the dune: this leads -- through the collision process -- to a coarsening of barchan fields. We show that these phenomena are not specific to the model, but result from general and robust mechanisms. The length scales needed for these instabilities to develop are derived and discussed. They turn out to be much smaller than the dune field length. As a conclusion, there should exist further - yet unknown - mechanisms regulating and selecting the size of dunes.Comment: 13 pages, 13 figures. New version resubmitted to Phys. Rev. E. Pictures of better quality available on reques

Examination of direct-photon and pion production in proton-nucleon collisions

We present a study of inclusive direct-photon and pion production in hadronic interactions, focusing on a comparison of the ratio of gamma/pi0 yields with expectations from next-to-leading order perturbative QCD (NLO pQCD). We also examine the impact of a phenomenological model involving k_T smearing (which approximates effects of additional soft-gluon emission) on absolute predictions for photon and pion production and their ratio.Comment: 20 pages, 12 figures. Minor changes in wording and in figure

Evidence for Parton kT Effects in High pT Particle Production

Inclusive pizero and direct-photon cross sections in the kinematic range 3.5 < pT < 12 GeV/c with central rapidities are presented for 530 and 800 GeV/c proton beams and a 515 GeV/c pi- beam incident on beryllium targets. Current Next-to-Leading-Order perturbative QCD calculations fail to adequately describe the data for conventional choices of scales. Kinematic distributions from these hard scattering events provide evidence that the interacting partons carry significant initial-state parton transverse momentum (kT). Incorporating these kT effects phenomenologically greatly improves the agreement between calculations and the measured cross sections.Comment: 11 pages including 6 pages of figures with caption

Phase Transitions in Rotating Neutron Stars

As rotating neutron stars slow down, the pressure and the density in the core region increase due to the decreasing centrifugal forces and phase transitions may occur in the center. We extract the analytic behavior near the critical angular velocity $\Omega_0$, where the phase transitions occur in the center of a neutron star, and calculate the moment of inertia, angular velocity, rate of slow down, braking index, etc. For a first order phase transition these quantities have a characteristic behavior, e.g., the braking index diverges as $\sim(\Omega_0-\Omega)^{-1/2}$. Observational consequences for first, second and other phase transitions are discussed.Comment: 5 pages, one figure included, revtex latex styl