27 research outputs found

    Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

    Get PDF
    OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

    Financial crisis and executive remuneration in banking industry - an analysis of five British banks

    No full text
    The recent financial crisis has accelerated the debate of executive remuneration. Theoretically, there are divergences between the design of executive remuneration suggested by agency theory and reality. In this study, we contribute to this debate by re-visiting the theories underlying the design of executive remuneration and providing empirical evidence from the recently banking failures in the UK. Empirically, we find that ineffective executive remuneration could contribute significantly to business failure. The lavish executive remuneration packages of the five troubled British banks do not reflect the companies' performances and provide little reward to the shareholders. Theoretically, we find that the executive remuneration design derived from a single agency perspective is insufficient to provide convincing explanation to the real business world during the financial crisis. Prospect theory, real option theory and the managerial power approach all together would complement agency theory to bring the theory of executive remuneration closer to reality. Our extended theoretical framework sheds some lights on the factors that undermine the executive remuneration that a single agency theory does not take into account, and thus have valuable policy implications for improving executive remuneration design in the future.agency theory, bank, executive remuneration, financial crisis,

    Abu Ghraib and the War against Terror - a case against Donald Rumsfeld

    Get PDF
    The pictures of the inhuman and abusive treatment of Iraqi prisoners at the Abu Ghraib prison shocked the world. The authors of this contribution will take a criminological approach to the crimes committed and will show—by using an analytical framework used by organizational criminologists—that the abuse and torture at Abu Ghraib was an inevitable outcome of the War on Terror as launched by the U.S. administration in a reaction to the terrorist attack launched against it. The abuse at Abu Ghraib which violated U.S. as well as international human rights law was not caused by a few rotten apples as policymakers tried to make us believe, but was a clear example of a state crime. A state crime for which U.S. leaders within the Bush administration such as the Secretary of Defense Donald Rumsfeld, might be held criminally responsible if they would be prosecuted by the ICC
    corecore