16 research outputs found

    Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

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    OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

    Status of coral reefs in the Fiji Islands, 2004

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    Abu Ghraib and the War against Terror - a case against Donald Rumsfeld

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    The pictures of the inhuman and abusive treatment of Iraqi prisoners at the Abu Ghraib prison shocked the world. The authors of this contribution will take a criminological approach to the crimes committed and will show—by using an analytical framework used by organizational criminologists—that the abuse and torture at Abu Ghraib was an inevitable outcome of the War on Terror as launched by the U.S. administration in a reaction to the terrorist attack launched against it. The abuse at Abu Ghraib which violated U.S. as well as international human rights law was not caused by a few rotten apples as policymakers tried to make us believe, but was a clear example of a state crime. A state crime for which U.S. leaders within the Bush administration such as the Secretary of Defense Donald Rumsfeld, might be held criminally responsible if they would be prosecuted by the ICC
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