Value-in-exchange or value-in-use? Empirical insights into consumer perceptions.

This paper considers consumer perceptions of value against the background of emerging paradigm shifts in marketing moving away from traditional transactional ‘value-in-exchange’ approaches where marketers create value for consumers, towards a concept of ‘value-in-use’ where it is the consumer who creates the value with the organisation deemed to be at best only a co-creator. Much of the relevant literature on governmental interventions is located within the public health arena, yet there is little which examines issues of value or value creation. This paper also therefore addresses this gap in the extant literature by considering issues of value in relation to engagement in physical activity and health in a leisure service setting

Towards developing understanding of the drivers, constraints from the consumption values underpinning participation in physical activity.

Overall participation rates in physical activity across the UK have remained relatively static since the mid 1980s, with attendant causes for concern about the inequality of participation rates amongst various target groups that may be worthy of specific investigation. Behaviour change models from the fields of leisure studies, consumer behaviour and social psychology offer conceptualisation of a notion of exchange underpinning the expectancy-value process, noting that, in order to facilitate a voluntary exchange there needs to be a value proposition that induces action and/or motivates effort from the consumer. It is therefore reasonable to assume that such value expectations will also influence health behaviour intentions. This paper therefore aims to offer a more developing understanding of the drivers, constraints and experiential consumption values underpinning participation in physical activity. Results suggest that, rather than focusing on the social and altruistic values of behavioural changes, and given that the functional value of participation is already well-known (if not always acted upon) through social marketing campaigns’ educational efforts and through the media, it may be worth policymakers and leisure service providers focusing more on highlighting the emotional benefits to be gained, especially when targeting women to increase their participation in physical activit

Why don’t people do what’s good for them? : an examination of the value(s) which affect physical activity.

One of the 21st Century’s major public health issues is physical inactivity. Therefore one of the greatest public policy challenges is to find new ways of conferring to an inactive population the health related benefits that arise from being physically active in a way that not only leads to knowledge acquisition, but which also leads to increased levels of participation in physical activity. Participation rates in physical activity across the UK have remained stubbornly static since the mid‐ 1980s and retain a range of gender, age, social‐economic and ethnic participation inequalities. Research has indicated that, when compared to men, women are more likely to: lead sedentary lifestyles (Hausenblas and Symons‐Downs, 2005), experience poor health (Bertakis et al., 2000), and feel more uncomfortable about their body image (Liechty et al., 2006), factors which impact on and/or result in lower participation levels, suggesting that social marketing campaigns to date have been largely ineffective. A central tenet of social marketing is to achieve a voluntary, not forced or coerced behaviour change by emphasising a value proposition that induces action from the consumer. Set in the context of publicly funded leisure facilities this paper offers empirical insights regarding the drivers, constraints and consumption values underpinning women’s participation in physical activity. Our results suggest that value perceptions regarding the costs, benefits and enjoyment of exercise do not differ with gender. However, statistically significant differences exist between the genders regarding: the physical environment within which exercise occurs; the quality of service experience; and intrinsic factors such as social and altruistic value. Insights gained from this research may be able to inform policymakers and leisure services providers regarding more effective methods of engaging ‘hard‐to‐reach’ groups, such as women. Specifically, our findings suggest that exercise adoption is likely to be increased with targeted social marketing campaigns which focus on emphasising the experiential aspects of consuming physical activity viewed from the perspective of value‐in‐use rather than from the traditional price‐based perspective that tends to focus on the trade off of costs against benefits

Global patterns in students’ views of science and interest in science

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.International studies have shown that interest in science and technology among primary and secondary school students in Western European countries is low and seems to be decreasing. In many countries outside Europe, and especially in developing countries, interest in science and technology remains strong. As part of the large-scale European Union funded ‘Science Education for Diversity’ project, a questionnaire probing potential reasons for this difference was completed by students in the UK, Netherlands, Turkey, Lebanon, India and Malaysia. This questionnaire sought information about favourite courses, extracurricular activities and views on the nature of science. Over 9,000 students aged mainly between 10 and 14 years completed the questionnaire. Results revealed that students in countries outside Western Europe showed a greater interest in school science, in careers related to science and in extracurricular activities related to science than didWestern European students. Non-European studentswere also more likely to hold an empiricist viewof the nature of science and to believe that science can solve many problems faced by the world. Multilevel analysis revealed a strong correlation between interest in science and having such a view of the Nature of Science.This publication received funding from the European Union Science in Society Framework 7 Programme (FP7/2007/2013) under grant agreement 244717. We would like to thank the following people for collecting data and contributing to this research project: Roel Janssen, Huseyin Bag, Lindsay Hetherington, Alun Morgan, Keith Postlethwaite, Rupert Wegerif, Ng Swee Chin, Choy Siew Chee, Oo Pou San, Chin Fui Chung, Teh Lee Wah, Sugra Chunawala, Chitra Natarajan and Beena Chok

A comparison of A-level performance in economics and business studies: how much more difficult is economics?

This paper uses ALIS data to compare academic performance in two subjects often viewed as relatively close substitutes for one another at A-level. The important role of GCSE achievement is confirmed for both subjects. There is evidence of strong gender effects and variation in outcomes across Examination Boards. A counterfactual exercise suggests that if the sample of Business Studies candidates had studied Economics nearly 40% of those who obtained a grade C or better in the former subject would not have done so in the latter. The opposite exercise uggests that 12% more Economics candidates would have achieved a grade C or better if they had taken Business Studies. In order to render a Business Studies A-level grade comparable to an Economics one in terms of relative difficulty, we estimate that a downward adjustment of 1.5 UCAS points should be applied to the former subject. This adjustment is lower than that suggested by correction factors based on conventional subject pair analysis for these two subjects

Localized Populations of CD8low/− MHC Class I Tetramer+ SIV-Specific T Cells in Lymphoid Follicles and Genital Epithelium

CD8 T cells play an important role in controlling viral infections. We investigated the in situ localization of simian immunodeficiency virus (SIV)-specific T cells in lymph and genital tissues from SIV-infected macaques using MHC-class I tetramers. The majority of tetramer-binding cells localized in T cell zones and were CD8+. Curiously, small subpopulations of tetramer-binding cells that had little to no surface CD8 were detected in situ both early and late post-infection, and in both vaginally and rectally inoculated macaques. These tetramer+CD8low/− cells were more often localized in apparent B cell follicles relative to T cell zones and more often found near or within the genital epithelium than the submucosa. Cells analyzed by flow cytometry showed similar populations of cells. Further immunohistological characterization revealed small populations of tetramer+CD20− cells inside B cell follicles and that tetramer+ cells did not stain with γδ-TCR nor CD4 antibodies. Negative control tetramer staining indicated that tetramer+CD8low/− cells were not likely NK cells non-specifically binding to MHC tetramers. These findings have important implications for SIV-specific and other antigen-specific T cell function in these specific tissue locations, and suggest a model in which antigen-specific CD8+ T cells down modulate CD8 upon entering B cell follicles or the epithelial layer of tissues, or alternatively a model in which only antigen-specific CD8 T cells that down-modulate CD8 can enter B cell follicles or the epithelium

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum

Plasmodium falciparum, the causative agent of human malaria, expresses two aminopeptidases, PfM1AAP and PfM17LAP, critical to generating a free amino acid pool used by the intraerythrocytic stage of the parasite for proteins synthesis, growth and development. These exopeptidases are potential targets for the development of a new class of anti-malaria drugs.To define the substrate specificity of recombinant forms of these two malaria aminopeptidases we used a new library consisting of 61 fluorogenic substrates derived both from natural and unnatural amino acids. We obtained a detailed substrate fingerprint for recombinant forms of the enzymes revealing that PfM1AAP exhibits a very broad substrate tolerance, capable of efficiently hydrolyzing neutral and basic amino acids, while PfM17LAP has narrower substrate specificity and preferentially cleaves bulky, hydrophobic amino acids. The substrate library was also exploited to profile the activity of the native aminopeptidases in soluble cell lysates of P. falciparum malaria.This data showed that PfM1AAP and PfM17LAP are responsible for majority of the aminopeptidase activity in these extracts. These studies provide specific substrate and mechanistic information important for understanding the function of these aminopeptidases and could be exploited in the design of new inhibitors to specifically target these for anti-malaria treatment

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide

BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. Antiretroviral chemotherapeutics have decreased AIDS mortality in industrialized countries, but only minimally in developing countries. To prevent an analogous dichotomy, microbicides should be: acceptable; accessible; affordable; and accelerative in transition from development to marketing. Already marketed pharmaceutical excipients or foods, with established safety records and adequate anti-HIV-1 activity, may provide this option. METHODS: Fruit juices were screened for inhibitory activity against HIV-1 IIIB using CD4 and CXCR4 as cell receptors. The best juice was tested for inhibition of: (1) infection by HIV-1 BaL, utilizing CCR5 as the cellular coreceptor; and (2) binding of gp120 IIIB and gp120 BaL, respectively, to CXCR4 and CCR5. To remove most colored juice components, the adsorption of the effective ingredient(s) to dispersible excipients and other foods was investigated. A selected complex was assayed for inhibition of infection by primary HIV-1 isolates. RESULTS: HIV-1 entry inhibitors from pomegranate juice adsorb onto corn starch. The resulting complex blocks virus binding to CD4 and CXCR4/CCR5 and inhibits infection by primary virus clades A to G and group O. CONCLUSION: These results suggest the possibility of producing an anti-HIV-1 microbicide from inexpensive, widely available sources, whose safety has been established throughout centuries, provided that its quality is adequately standardized and monitored

Balance in single-limb stance in healthy subjects – reliability of testing procedure and the effect of short-duration sub-maximal cycling

BACKGROUND: To assess balance in single-limb stance, center of pressure movements can be registered by stabilometry with force platforms. This can be used for evaluation of injuries to the lower extremities. It is important to ensure that the assessment tools we use in the clinical setting and in research have minimal measurement error. Previous studies have shown that the ability to maintain standing balance is decreased by fatiguing exercise. There is, however, a need for further studies regarding possible effects of general exercise on balance in single-limb stance. The aims of this study were: 1) to assess the test-retest reliability of balance variables measured in single-limb stance on a force platform, and 2) to study the effect of exercise on balance in single-limb stance, in healthy subjects. METHODS: Forty-two individuals were examined for test-retest reliability, and 24 individuals were tested before (pre-exercise) and after (post-exercise) short-duration, sub-maximal cycling. Amplitude and average speed of center of pressure movements were registered in the frontal and sagittal planes. Mean difference between test and retest with 95% confidence interval, the intraclass correlation coefficient, and the Bland and Altman graphs with limits of agreement, were used as statistical methods for assessing test-retest reliability. The paired t-test was used for comparisons between pre- and post-exercise measurements. RESULTS: No difference was found between test and retest. The intraclass correlation coefficients ranged from 0.79 to 0.95 in all stabilometric variables except one. The limits of agreement revealed that small changes in an individual's performance cannot be detected. Higher values were found after cycling in three of the eight stabilometric variables. CONCLUSIONS: The absence of systematic variation and the high ICC values, indicate that the test is reliable for distinguishing among groups of subjects. However, relatively large differences in an individual's balance performance would be required to confidently state that a change is real. The higher values found after cycling, indicate compensatory mechanisms intended to maintain balance, or a decreased ability to maintain balance. It is recommended that average speed and DEV 10; the variables showing the best reliability and effects of exercise, be used in future studies