Gas Rich Dwarfs from the PSS-II III. HI Profiles and Dynamical Masses

We present Arecibo neutral hydrogen data on a sample of optically selected dwarf galaxies. The sample ranges in HI mass from 10^6 M_sun to 5x10^9 M_sun, with a mean of 7.9x10^8 M_sun. Using estimated HI radii, the HI surface densities range from 0.6 to 20 M_sun pc^-2, all well below the critical threshold for star formation (Kennicutt 1998). M_HI/L values of the LSB dwarfs range from 0.3 to 12 with a mean value of 2.0. Dynamical masses, calculated from the HI profile widths, range from 10^8 M_sun to 10^11 M_sun. There is a strong correlation between optical luminosity and dynamical mass for LSB dwarfs implying that the dark matter (whether baryonic or non-baryonic) follows the detectable baryonic matter.Comment: 53 pages, AASTeX v4.0, 8 figures, to be published in ApJ Suppl, images, tables and referee report can be found at http://zebu.uoregon.edu/~j

Best-BRA (Is subpectoral or pre-pectoral implant placement best in immediate breast reconstruction?) A protocol for a pilot randomised controlled trial of subpectoral versus pre-pectoral immediate implant-based breast reconstruction in women following mastectomy

Background: implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure following mastectomy. IBBR techniques are evolving rapidly, with mesh-assisted subpectoral reconstruction becoming the standard of care and more recently, prepectoral techniques being introduced. These muscle-sparing techniques may reduce postoperative pain, avoid implant animation and improve cosmetic outcomes and have been widely adopted into practice. Although small observational studies have failed to demonstrate any differences in the clinical or patient-reported outcomes of prepectoral or subpectoral reconstruction, high-quality comparative evidence of clinical or cost-effectiveness is lacking. A well-designed, adequately powered randomised controlled trial (RCT) is needed to compare the techniques, but breast reconstruction RCTs are challenging. We, therefore, aim to undertake an external pilot RCT (Best-BRA) with an embedded QuinteT Recruitment Intervention (QRI) to determine the feasibility of undertaking a trial comparing prepectoral and subpectoral techniques.Methods and analysis: best-BRA is a pragmatic, two-arm, external pilot RCT with an embedded QRI and economic scoping for resource use. Women who require a mastectomy for either breast cancer or risk reduction, elect to have an IBBR and are considered suitable for both prepectoral and subpectoral reconstruction will be recruited and randomised 1:1 between the techniques.The QRI will be implemented in two phases: phase 1, in which sources of recruitment difficulties are rapidly investigated to inform the delivery in phase 2 of tailored interventions to optimise recruitment of patients.Primary outcomes will be (1) recruitment of patients, (2) adherence to trial allocation and (3) outcome completion rates. Outcomes will be reviewed at 12 months to determine the feasibility of a definitive trial.Ethics and dissemination: the study has been approved by the National Health Service (NHS) Wales REC 6 (20/WA/0338). Findings will be presented at conferences and in peer-reviewed journals.Trial registration number: ISRCTN10081873.</p

QCD and strongly coupled gauge theories : challenges and perspectives

We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe

Predictors of satisfaction and quality of life following post-mastectomy breast reconstruction

Objective: Breast reconstruction is associated with multiple psychological benefits. However, few studies have identified clinical and psychological factors associated with improved satisfaction and quality of life. This study examined factors which predict satisfaction with breast appearance, outcome satisfaction and quality of life following post-mastectomy breast reconstruction. Methods: Women who underwent post-mastectomy breast reconstruction between 2010 and 2016 received a postal questionnaire consisting of: The BREAST-Q Patient Reported Outcomes Instrument, The European Organisation for Research and Treatment of Cancer QLQ-30 Questionnaire, The Patient and Observer Scar Assessment Scale and a series of Visual-Analogue Scales. One hundred and forty eight women completed the questionnaire, a 56% response rate. Results: Hierarchical multiple regression analyses revealed psychosocial factors accounted for 75% of the variance in breast satisfaction, 68% for outcome satisfaction and 46% for quality of life. Psychosocial wellbeing emerged as a significant predictor of satisfaction with breast appearance (β=.322) and outcome satisfaction (β=.406). Deep inferior epigastric perforator flap (DIEP) patients reported greater satisfaction with breast appearance (β=.120) and outcome satisfaction (β=.167). Conclusions: This study extends beyond limited research by distinguishing between satisfaction with breast appearance and outcome satisfaction. The study provides preliminary evidence for the role of psychosocial factors predicting key patient reported outcomes and demonstrates the importance of psychosocial wellbeing and reconstruction type. Healthcare providers could assess psychosocial wellbeing prior to reconstruction to support optimal recovery. Clinicians could also use the findings of this study to justify the use of DIEP over implant reconstructions