390 research outputs found
Structures 2 - The response of a clamped circular plate to impulsive loads
Computer analysis of clamped circular plate response to axisymmetric impulsive loa
Structures i- the response of beams and rings to high-intensity, short-duration loading
Computer programs for determining response of beams and rings to high intensity, short duration loadin
On the electromagnetic properties of active media
Several results concerning active media or metamaterials are proved and
discussed. In particular, we consider the permittivity, permeability, wave
vector, and refractive index, and discuss stability, refraction, gain, and
fundamental limitations resulting from causality
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109971/1/cptclpt20132.pd
Controlling passively-quenched single photon detectors by bright light
Single photon detectors based on passively-quenched avalanche photodiodes can
be temporarily blinded by relatively bright light, of intensity less than a
nanowatt. I describe a bright-light regime suitable for attacking a quantum key
distribution system containing such detectors. In this regime, all single
photon detectors in the receiver Bob are uniformly blinded by continuous
illumination coming from the eavesdropper Eve. When Eve needs a certain
detector in Bob to produce a click, she modifies polarization (or other
parameter used to encode quantum states) of the light she sends to Bob such
that the target detector stops receiving light while the other detector(s)
continue to be illuminated. The target detector regains single photon
sensitivity and, when Eve modifies the polarization again, produces a single
click. Thus, Eve has full control of Bob and can do a successful
intercept-resend attack. To check the feasibility of the attack, 3 different
models of passively-quenched detectors have been tested. In the experiment, I
have simulated the intensity diagrams the detectors would receive in a real
quantum key distribution system under attack. Control parameters and side
effects are considered. It appears that the attack could be practically
possible.Comment: Experimental results from a third detector model added. Minor
corrections and edits made. 11 pages, 10 figure
Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109858/1/cptclpt2011174.pd
Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update
CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic antidepressants (TCAs), with some drugs being affected by CYP2D6 only (e.g., nortriptyline and desipramine) and others by both polymorphic enzymes (e.g., amitriptyline, clomipramine, doxepin, imipramine, and trimipramine). Evidence is presented for CYP2D6 and CYP2C19 genotype-directed dosing of TCAs. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants
Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET study
CONTEXT: Hot flashes are a common side effect of adjuvant endocrine therapies (AET; leuprolide, tamoxifen, aromatase inhibitors) that reduce quality of life and treatment adherence in breast cancer patients. Because hot flashes affect only some women, preexisting neurobiological traits might predispose to their development. Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction. OBJECTIVE: The aim of the study was to understand whether neurobiological factors predict hot flashes. DESIGN: [18F]-Fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans coregistered with structural magnetic resonance imaging were used to determine whether metabolic activity in the insula and hypothalamic thermoregulatory and estrogen-feedback regions measured before and in response to AET predict hot flashes. Findings were correlated with CYP2D6 genotype because of CYP2D6 polymorphism associations with tamoxifen-induced hot flashes. OUTCOME MEASURES: We measured regional cerebral metabolic rate of glucose uptake (rCMRglu) in the insula and hypothalamus on FDG-PET. RESULTS: Of 18 women without hot flashes who began AET, new-onset hot flashes were reported by 10 (55.6%) and were detected objectively in nine (50%) participants. Prior to the use of all AET, rCMRglu in the insula (P ≤ 0.01) and hypothalamic thermoregulatory (P = 0.045) and estrogen-feedback (P = 0.007) regions was lower in women who reported developing hot flashes. In response to AET, rCMRglu was further reduced in the insula in women developing hot flashes (P ≤ 0.02). Insular and hypothalamic rCMRglu levels were lower in intermediate than extensive CYP2D6 metabolizers. CONCLUSIONS: Trait neurobiological characteristics predict hot flashes. Genetic variability in CYP2D6 may underlie the neurobiological predisposition to hot flashes induced by AET
Detector decoy quantum key distribution
Photon number resolving detectors can enhance the performance of many
practical quantum cryptographic setups. In this paper, we employ a simple
method to estimate the statistics provided by such a photon number resolving
detector using only a threshold detector together with a variable attenuator.
This idea is similar in spirit to that of the decoy state technique, and is
specially suited for those scenarios where only a few parameters of the photon
number statistics of the incoming signals have to be estimated. As an
illustration of the potential applicability of the method in quantum
communication protocols, we use it to prove security of an entanglement based
quantum key distribution scheme with an untrusted source without the need of a
squash model and by solely using this extra idea. In this sense, this detector
decoy method can be seen as a different conceptual approach to adapt a single
photon security proof to its physical, full optical implementation. We show
that in this scenario the legitimate users can now even discard the double
click events from the raw key data without compromising the security of the
scheme, and we present simulations on the performance of the BB84 and the
6-state quantum key distribution protocols.Comment: 27 pages, 7 figure
Small Molecule Inhibitors of Staphylococcus aureus RnpA Alter Cellular mRNA Turnover, Exhibit Antimicrobial Activity, and Attenuate Pathogenesis
Methicillin-resistant Staphylococcus aureus is estimated to cause more U.S. deaths annually than HIV/AIDS. The emergence of hypervirulent and multidrug-resistant strains has further amplified public health concern and accentuated the need for new classes of antibiotics. RNA degradation is a required cellular process that could be exploited for novel antimicrobial drug development. However, such discovery efforts have been hindered because components of the Gram-positive RNA turnover machinery are incompletely defined. In the current study we found that the essential S. aureus protein, RnpA, catalyzes rRNA and mRNA digestion in vitro. Exploiting this activity, high through-put and secondary screening assays identified a small molecule inhibitor of RnpA-mediated in vitro RNA degradation. This agent was shown to limit cellular mRNA degradation and exhibited antimicrobial activity against predominant methicillin-resistant S. aureus (MRSA) lineages circulating throughout the U.S., vancomycin intermediate susceptible S. aureus (VISA), vancomycin resistant S. aureus (VRSA) and other Gram-positive bacterial pathogens with high RnpA amino acid conservation. We also found that this RnpA-inhibitor ameliorates disease in a systemic mouse infection model and has antimicrobial activity against biofilm-associated S. aureus. Taken together, these findings indicate that RnpA, either alone, as a component of the RNase P holoenzyme, and/or as a member of a more elaborate complex, may play a role in S. aureus RNA degradation and provide proof of principle for RNA catabolism-based antimicrobial therapy
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