ANALISIS PENGARUH TYPE OF CONFORMITY DAN EMOTIONAL INTELLIGENCE TERHADAP KEPATUHAN CUCI TANGAN KARYAWAN (Studi di Instalasi Rawat Inap Rumah Sakit Umum Haji Surabaya)

Beberapa faktor yang mempengaruhi tingkat kepatuhan cuci tangan adalah type of conformity dan emotional intelligence karyawan. Tujuan penelitian ini adalah mengeluarkan rekomendasi upaya meningkatkan kepatuhan cuci tangan karyawan berdasarkan analisis type of conformity dan emotional intelligence. Metode penelitian menggunakan pendekatan kuantitatif dengan cross sectional yang dilaksanakan pada periode September hingga Oktober tahun 2017. Teknik pengumpulan data menggunakan kuesioner. Populasi dalam penelitian adalah seluruh karyawan yang bekerja di unit pelayanan rawat inap Rumah Sakit Umum Haji Surabaya. Jumlah populasi sebesar 287 karyawan dengan 202 orang berprofesi perawat, 29 orang bidan, dan 56 orang berprofesi pekarya rumah sakit. Sampel penelitian adalah sebagian karyawan unit pelayanan rawat inap yang terbagi ke dalam 12 ruangan. Teknik sampling yang digunakan adalah proportionate stratified random sampling sehingga didapatkan sampel sejumlah 167 karyawan. Pengambilan sampel setiap ruangan dilakukan secara acak (random) dengan kriteria sampel adalah karyawan yang bekerja di unit pelayanan rawat inap dan bersedia mengisi kuesioner dengan dibuktikan melalui infromed consent. Instrumen penelitian yang dipakai adalah kuesioner. Hasil penelitian secara deskriptif menunjukkan bahwa sebagian besar karyawan unit pelayanan rawat inap berada pada kelompok usia dewasa awal (60,5%), berjenis kelamin perempuan, tingkat pendidikan setingkat Diploma, dengan masa kerja lebih dari 5 tahun. Hasil penelitian memberikan informasi bahwa mayoritas karyawan telah memiliki tipe kepatuhan pada tingkatan internalization (98%). Mayoritas karyawan memiliki aspek emotional intelligence berupa self motivation yang baik dan mayoritas karyawan memiliki tingkat kepatuhan cuci tangan pada tingkatan baik. Hasil uji pengaruh menunjukkan terdapat pengaruh yang signifikan antara type of conformity terhadap tingkat kepatuhan cuci tangan karyawan (p<0,05). Aspek emotional intelligence yang memberikan pengaruh signifikan terhadap tingkat kepatuhan cuci tangan karyawan adalah self motivation, self awareness, dan empathy (p<0,05). Rekomendasi adalah (1) menyusun suatu sistem reward and punishment (2) mengatur proporsi jumlah perawat dan tempat tidur (3) mengatur ulang peletakan fasilitas hand rub dan membuat bahan hand rub yang dapat diterima kulit tangan karyawan (4) memunculkan suatu program dengan tujuan memberikan informasi terkait pentingnya cuci tangan terhadap keselamatan diri dan pasien (6) mengadakan forum berbagi pengalaman masalah selama bekerja dengan mengundang tenaga ahli agar dapat menumbuhkan empati dalam diri karyawan

EVALUASI KEBERHASILAN STRATEGI BISNIS KOMERSIALISASI TEKNOLOGI PADA INCUBATEE (STUDI KASUS : INCUBATEE BIT-BPPT)

ABSTRAK Ajeng Sista Palupi Cakrasiwi, I0311003. EVALUASI KEBERHASILAN STRATEGI BISNIS KOMERSIALISASI TEKNOLOGI PADA INCUBATEE (STUDI KASUS : INCUBATEE DI BIT-BPPT). Skripsi. Surakarta: Program Studi Sarjana Teknik Industri, Fakultas Teknik, Universitas Sebelas Maret, Oktober 2015. Komersialisasi teknologi merupakan serangkaian proses dari pengembangan dan pemasaran sebuah teknologi. Teknologi tersebut dirancang untuk mencapai suatu titik yang dapat diaplikasikan pada suatu kegiatan produksi atau konsumsi sehingga dapat menghasilkan keuntungan. Sukses atau tidaknya komersialisasi bisnis berbasis teknologi dipengaruhi oleh beberapa faktor. Faktor-faktor tersebut antara lain kapasitas incubatee sebagai pengusaha berbasis teknologi, pusat inkubasi yang melakukan proses inkubasi kepada incubatee, dan mentor yang mendampingi incubatee. Penelitian ini menggunakan studi kasus di BIT-BPPT yang merupakan salah satu pusat inkubasi dibawah Kemenristek. Incubatee di BIT-BPPT terbagi menjadi 4 (empat) yaitu manufaktur, ICT, EES (Energy, Environment, Service), dan Agroindustri. Menurut data incubatee yang dikelola secara mandiri didalam BIT-BPPT menunjukkan bahwa angka survival rate pusat inkubasi ini dari tahun 2002 sampai 2014 yang lulus atau graduate adalah sebesar 29%. Angka yang cukup bersaing dengan pusat inkubasi lainnya di Indonesia. Namun, saat di benchmarking masih kurang apabila bersaing dengan negara maju. Sehingga perlu adanya evaluasi keberhasilan strategi bisnis komersialisasi teknologi oleh incubatee agar dapat meningkatkan survival rate lulusan incubatee di BIT-BPPT. Pada penelitian ini, dilakukan langkah-langkah pengolahan data menggunakan analisis crosstab dan analisis longitudinal. Kemudian, untuk melakukaan pemetaan strategi bisnis dilakukan pengolahan data menggunakan analisis SWOT yang dirumuskan dengan matrik IFAS dan EFAS. Analisis SWOT yang dihasilkan diverifikasi menggunakan FGD (Focus Group Disscussion) bersama dengan pengelola pusat inkubasi. Selanjutnya dilakukan pemetaan alternatif strategi bisnis menggunakan unsur manajemen 5M (Man, Method, Money, Material, Machine) dan unsur penguatan inkubator kepada incubatee. Hasil pemetaan strategi bisnis mengunakan analisis SWOT dan pemetaan alternatif strategi bisnis diharapkan dapat memberikan masukkan kepada BIT-BPPT, sehingga BIT-BPPT dapat menghasilkan lebih banyak luaran incubatee yang sukses dan dapat bersaing dengan pusat inkubasi lainnya. Kata kunci: alat ukur, komersialisasi teknologi, strategi bisnis, incubatee, pusat inkubasi, mentor xix + 119 halaman; 32 gambar; 42 tabel; Daftar Pustaka: 60 (1969-2015) ABSTRACT Ajeng Sista Palupi Cakrasiwi, I0311003. EVALUATION OF SUCCESS STRATEGY IN BUSINESS TECHNOLOGY COMMERCIALISATION BY INCUBATEE (CASE STUDY: INCUBATEE IN BIT-BPPT). Thesis. Surakarta: Undergraduate Program of Industrial Engineering Department, Faculty of Engineering, Sebelas Maret University, October 2015. Commercialization of the technology is a series of processes of developing and marketing a technology. The technology is designed to reach a point that can be applied to a production or consumption so as to make a profit. Success or failure of the commercialization of technology-based business is influenced by several factors. These factors include incubatee capacity as technology-based entrepreneurs, incubation center that perform the incubation process to incubatee, and mentor who accompanied incubatee. This study uses a case study at BIT-BPPT which is one incubation center under The Ministry Of Research and Technology. Incubatee at BIT-BPPT is divided into 4 (four), they are manufacture, ICT, EES (Energy, Environment, Service), and Agro-industry. According to data incubatee managed independently within the BIT-BPPT showed that the survival rate of this incubation center from 2002 to 2014 who passed or graduated is 29%. Figures are quite competitive with other incubation centers in Indonesia. However, when benchmarking is still lacking when competing with developed countries. So it is necessary to evaluate the success of the business strategy by incubatee commercialization of the technology in order to improve the survival rate of graduates incubatee at BIT-BPPT. In this study, carried out the steps of data processing using crosstab analysis and longitudinal analysis. Then, to make business strategy mapping, the data be treated by using the SWOT analysis with IFAS and EFAS matrix formulated. The resulting SWOT analysis is verified using FGD (Focus Group disscussion) together with the manager and staff of incubation center. Furthermore, the mapping of alternative business strategies using management element 5M (Man, Method, Money, Material, Machine) and a strengthening element of the incubator to incubatee. Results of mapping business strategy using SWOT analysis and mapping alternative business strategy expected to enter the BIT-BPPT, so the BIT-BPPT can produce more output incubatee successful and to compete with other incubation centers. Keywords: measuring tools, technology commercialization, business strategy, incubatee, incubation center, mentor xix + 119 pages; 32 figures; 42 tables; References: 60 (1969-2015

Application of the Weibull distribution for the optimization of maintenance policies of an electronic railway signaling system

ESREL 2017, European Safety and Reliability Conference, PORTOROZ, SLOVÉNIE, 18-/06/2017 - 22/06/2017This paper presents the advantages of using Weibull distribution to describe reliability figures of an electronic railway signaling system, respect to the commonly used exponential distribution. After presenting the context of reliability estimations within the railway domain, this work introduces the approach to use field-return data to build up reliability parameters instead of predictive methodologies, and it is applied to an existing electronic signaling system. A comparison between the two methodologies is also provided, as well as the introduction of further reliability indicators. A model to improve preventive maintenance tasks defining the optimum time interval is then presented and an example is provided. Some suggestions to improve the process of collecting field-return data are presented impacting both the after-sales logbook and the design of the circuit boards

DNA-protein interaction at the replication termini of plasmid R6K.

Understanding the molecular mechanism of specific and polarized termination of DNA replication at a sequence-specific replication terminus requires detailed analyses of the interaction of terminator protein (ter) with specific DNA sequences (tau), constituting the replication terminus. Such analyses should provide the structural basis of the functional polarity of replication inhibition observed in vivo and in vitro at tau sites. With this objective in mind, we have purified the replication terminator protein of Escherichia coli to homogeneity and have analyzed the interaction of the protein with the replication termini of R6K, using chemical probes and by site-directed mutagenesis. The results show that one monomer of ter protein binds to a single tau site with an equilibrium dissociation constant of 5 x 10(-9) moles/liter. Furthermore, a combination of alkylation interference and protection, hydroxyradical footprinting, and site-directed mutagenesis has revealed the phosphate groups and base residues of the tau core sequence that make contacts with ter protein and those residues that are important for both DNA-protein interaction and for termination of replication in vivo. The overall picture that emerges from these analyses reveals that ter forms an asymmetric complex with a tau sequence. Thus, the asymmetric ter-tau complex provides a structural basis for the functional polarity of the arrest of a moving replication fork at a tau site

Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies

Peripheral T cell lymphomas (PTCL) account for about 12% of lymphoid tumours worldwide. Almost half show such morphological and molecular variability as to hamper any further classification, and to justify their inclusion in a waste-basket category termed “not otherwise specified (NOS)”. The latter term is used for neoplasms with aggressive presentation, poor response to therapy and dismal prognosis. In contrast to B cell lymphomas, PTCL have been the subject of only a limited number of studies to elucidate their pathobiology and identify novel pharmacological approaches. Herewith, the authors revise the most recent contributions on the subject based on the experience they have gained in the extensive application of microarray technologies. PTCL/NOS are characterised by erratic expression of T cell associated antigens, including CD4 and CD52, which have recently been proposed as targets for ad hoc immunotherapies. PTCL/NOS also show variable Ki-67 marking, with rates >80% heralding a worse prognosis. Gene expression profiling studies have revealed that PTCL/NOS derive from activated T lymphocytes, more often of the CD4+ type, and bear a signature composed of 155 genes and related products that play a pivotal role in cell signalling transduction, proliferation, apoptosis and matrix remodelling. This observation seems to pave the way for the use of innovative drugs such as tyrosine kinase and histone deacetylase inhibitors whose efficacy has been proven in PTCL primary cell cultures. Gene expression profiling also allows better distinction of PTCL/NOS from angioimmunoblastic T cell lymphoma, the latter being characterised by follicular T helper lymphocyte derivation and CXCL13, PD1 and vascular endothelial growth factor expression

Trends and correlates of HIV-1 resistance among subjects failing an antiretroviral treatment over the 2003-2012 decade in Italy

BACKGROUND: Despite a substantial reduction in virological failures following introduction of new potent antiretroviral therapies in the latest years, drug resistance remains a limitation for the control of HIV-1 infection. We evaluated trends and correlates of resistance in treatment failing patients in a comprehensive database over a time period of relevant changes in prescription attitudes and treatment guidelines. METHODS: We analyzed 6,796 HIV-1 pol sequences from 49 centres stored in the Italian ARCA database during the 2003-2012 period. Patients (n = 5,246) with viremia > 200 copies/mL received a genotypic test while on treatment. Mutations were identified from IAS-USA 2013 tables. Class resistance was evaluated according to antiretroviral regimens in use at failure. Time trends and correlates of resistance were analyzed by Cochran-Armitage test and logistic regression models. RESULTS: The use of NRTI backbone regimens slightly decreased from 99.7% in 2003-2004 to 97.4% in 2010-2012. NNRTI-based combinations dropped from 46.7% to 24.1%. PI-containing regimens rose from 56.6% to 81.7%, with an increase of boosted PI from 36.5% to 68.9% overtime. In the same reference periods, Resistance to NRTIs, NNRTIs and PIs declined from 79.1% to 40.8%, from 77.8% to 53.8% and from 59.8% to 18.9%, respectively (p < .0001 for all comparisons). Dual NRTI + NNRTI and NRTI + PI resistance decreased from 56.4% to 33.3% and from 36.1% to 10.5%, respectively. Reduced risk of resistance over time periods was confirmed by a multivariate analysis. CONCLUSIONS: Mutations associated with NRTIs, NNRTIs and PIs at treatment failure declined overtime regardless of specific class combinations and epidemiological characteristics of treated population. This is likely due to the improvement of HIV treatment, including both last generation drug combinations and prescription guidelines