Concept of Infected Wound (Dushta Vrana) in Ayurveda

Man is the superior most creature of God, having a sufficient intellectual mind to discover new things andconcurrently overcome the existing problems. So from very ancient time different methods of wound carehave been described. Wound is a separation or break in continuity of skin, mucous membrane or tissuecaused by physical, chemical or biological insult. Wound infections continue to represent a major medicalproblem, both in terms of how they affect the outcome of surgical procedures and for their impact on thelength of hospital stay and medical costs. In Ayurveda, an infected wound may be co-related with dushtavrana. Sushruta has explained that “vrana” (wound) is so called as it covers the site and the scar and evenafter healing, does not disappear till the person lives. Proper wound care is necessary to prevent infectionand to promote healing of the wound. In this paper, emphasis has been given to dushta vrana and itsmanagement description according to Samhita and an attempt has been made to explain the infectedwound according to modern concept

Outsourcing Strategy in Avionics Manufacturing in Indian DPSUs

The Avionics manufacturer DPSUs is a high end technology oriented which involve in complex integration among their supplier vendors. The global competition of DPSUs not only related the manufacturing facility technology but also their supply chain. This research paper point out the outsourcing as a strategic tool for economic growth of DPSUs. In this paper researcher discuss the present challenges in supply chain for avionics manufacturer DPSUs and GOI policy for outsourcing. Researcher develop a strategic outsourcing model for avionics manufacturer DPSUs which application enhances their performance

Effect of Lakshadigana Taila on Wound Healing in Albino Rat

Objective: To investigate the wound-healing potency of the Lakshadigana Taila on the excisional woundhealing process in experimental study of albino rats, in comparison to 5% Povidone Iodine solution anduntreated group.Materials and Methods: Albino rats of either sex weighing between 200 and 300 gm were divided randomlyinto three groups (n=6). The animals were anesthetized with anesthetic agent Thiopentone Sodium 25mg/kg intra peritoneal. The skin of albino rats was saved on one side of paravertebral region. The skinwas disinfected using cotton and alcohol wipes. Excisional wound, full thickness skin wounds of diameter10 mm were created in the paravertebral area. The following medications were applied topically to thewound once daily for a maximum of 16 days. In Group I (trial group) Lakshadigana Taila was applied onrats, in Group II (positive control), 5% Povidone Iodine solution was applied on rats and Group III (negativecontrol) served as untreated. Wound was measured on days 0, 4, 8, 12 and 16 of the experiment andhistopathological of H and E stain study done on day 4 and 8, 12 and 16. Statistical analysis was doneusing analysis of One Way ANOVA followed by Post Hoc Test and P <0.05 was considered significant and<0.001 highly significant.Result: Area of wound was measured in all three groups at different intervals and found that the rate ofwound contraction was statistically highly significant in all groups (p <0.001). Rate of wound contractionwas faster in Group I than in Group II and III.Conclusion: In the present study, topical application of Lakshadigan Taila accelerated healing of excisionalwound in albino rats

Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes

We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general composition CuX(2) · (H(2)O)(L)(X = Cl, Br,NO(3),NCS, or CH(3)COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated

Complexes of Benzoylisonicotinic Acid Hydrazide with VO(II), Mn(II), Co(II), Ni(II), Cu(II) & Zn(II)

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Complexes of VO(IV), Mn(II), Co(II), Ni(II), Cu(II) & Zn(II) with N-Acetyl-N' –isonicotinoylhydrazine

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Synthesis, Biological, Spectral, and Thermal Investigations of Cobalt(II) and Nickel(II) Complexes of N-Isonicotinamido -2′,4′-Dichlorobenzalaldimine

A new series of 12 complexes of cobalt(II) and nickel(II) with N-isonicotinamido-2′,4′-dichlorobenzalaldimine (INH-DCB) with the general composition MX(2) · n(INH-DCB) [M = Co(II) or Ni(II), X = Cl(−) ,Br(−), NO(3)(−), NCS(−), or CH(3)COO(−), n = 2; X = ClO(4) (−), n = 3] have been synthesized. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, infrared, electronic spectra, magnetic susceptibility, and conductivity measurements. An octahedral geometry has been suggested for all the complexes. The metal complexes were screened for their antifungal and antibacterial activities on different species of pathogenic fungi and bacteria and their biopotency has been discussed

A Rare Case of Deep Vein Thrombosis Secondary to Protein S Deficiency and Antithrombin III Deficiency with MTHFR (C677T) Heterozygous Mutation, and Crohn’s Disease

Deep vein thrombosis is a condition wherein a thrombus develops in the deep veins of the body, most commonly in the legs, due to increasing tendency of the blood to coagulate. One such reason is the MTHFR gene mutation, wherein an increase in homocysteine levels causes irritation of the blood vessel endothelium, causing a disturbance in Virchow’s triad, hence triggering clot formation. [1] The MTHFR gene is responsible for instructing the body to produce an enzyme called methylene tetrahydrofolate reductase(MTHFR) [2]. MTHFR gene mutations can lead to a wide range of disorders, either as a result of the elevated levels of homocysteine in the blood, or due to folate deficiency. In about 25% of individuals globally, there is a mutation of MTHFR. The MTHFR 677C\u3eT mutation is predominantly seen in the Hispanic ethnicity, whereas the MTHFR 128A\u3eC is predominantly seen in the ethnicity groups belonging to south east Asia. In the Indian population, the MTHFR mutation prevails a low frequency of 2.9%. Diagnosis and treatment are required only in cases where secondary diseases occur as a result of MTHFR polymorphism, or if there is significant family history [4]. The treatment is along the same lines as that of another diagnosed individual without the mutation. In this case, the correlation between a genetic mutation of the MTHFR gene and Protein S and Antithrombin III deficiency, along with Crohn\u27s disease, which resulted in the development of DVT in a middle aged, male individual and its management is discussed

Correlation of doppler studies at 34 weeks of gestation with perinatal outcome in high risk pregnancies

Background: Antepartum detection of the fetus at risk of death or compromise in utero remains a major challenge in modern obstetrics. The waveform analysis of the feto- maternal circulation by Doppler ultrasound has therefore become a quick and a simple way of screening and identifying fetal compromise. The main objective of the study is to evaluate Doppler flow indices as an index for assessing fetal well being in high risk pregnancies and to determine the predictive value of various Doppler parameters with perinatal outcome.Methods: The study was a prospective cohort study were forty pregnant women with a high risk factor (intrauterine growth restriction, pre eclampsia and gestational diabetes mellitus) and forty pregnant women with no high risk(controls) were selected at 34 weeks of gestation. Both the groups underwent an obstetrical ultrasound with color Doppler examination of bilateral uterine arteries, umbilical artery and middle cerebral artery. Abnormality was serially monitored and pregnancy terminated in the presence of absent, reversal of end diastolic flow in umbilical artery or non-reassuring tests of fetal wellbeing.Results: Uterine artery S/D abnormality was seen in 32.5% of high risk cases were as abnormal umbilical artery S/D was seen in 25% and abnormal Pulsatility Index (PI) in 15% cases. Middle cerebral artery flow was abnormal in only 17.5% cases. Abnormality in the uterine artery flow correlated well with the incidence of preterm delivery (69.2%), need for cesarean section (53.8%) and length of Neonatal intensive care unit(NICU) stay >48 hours (69.23%). Abnormal umbilical artery flow was associated with a significant increase in the incidence of preterm delivery(75%), small for gestational age babies(93.75%) and length of NICU stay >48 hours (93.75%). There was no significant correlation seen with isolated abnormal middle cerebral artery flow.Conclusions: Both uterine and umbilical artery Doppler velocities correlate well with the perinatal outcome but abnormal uterine artery Doppler predicts adverse neonatal outcome better than the fetal vessels as it discriminates fetuses at risk because of abnormal placental vascularisation from those who are at risk due to other causes