Objective: To investigate the wound-healing potency of the Lakshadigana Taila on the excisional woundhealing process in experimental study of albino rats, in comparison to 5% Povidone Iodine solution anduntreated group.Materials and Methods: Albino rats of either sex weighing between 200 and 300 gm were divided randomlyinto three groups (n=6). The animals were anesthetized with anesthetic agent Thiopentone Sodium 25mg/kg intra peritoneal. The skin of albino rats was saved on one side of paravertebral region. The skinwas disinfected using cotton and alcohol wipes. Excisional wound, full thickness skin wounds of diameter10 mm were created in the paravertebral area. The following medications were applied topically to thewound once daily for a maximum of 16 days. In Group I (trial group) Lakshadigana Taila was applied onrats, in Group II (positive control), 5% Povidone Iodine solution was applied on rats and Group III (negativecontrol) served as untreated. Wound was measured on days 0, 4, 8, 12 and 16 of the experiment andhistopathological of H and E stain study done on day 4 and 8, 12 and 16. Statistical analysis was doneusing analysis of One Way ANOVA followed by Post Hoc Test and P <0.05 was considered significant and<0.001 highly significant.Result: Area of wound was measured in all three groups at different intervals and found that the rate ofwound contraction was statistically highly significant in all groups (p <0.001). Rate of wound contractionwas faster in Group I than in Group II and III.Conclusion: In the present study, topical application of Lakshadigan Taila accelerated healing of excisionalwound in albino rats
