The interaction energy of well-separated Skyrme solitons

We prove that the asymptotic field of a Skyrme soliton of any degree has a non-trivial multipole expansion. It follows that every Skyrme soliton has a well-defined leading multipole moment. We derive an expression for the linear interaction energy of well-separated Skyrme solitons in terms of their leading multipole moments. This expression can always be made negative by suitable rotations of one of the Skyrme solitons in space and iso-space.We show that the linear interaction energy dominates for large separation if the orders of the Skyrme solitons' multipole moments differ by at most two. In that case there are therefore always attractive forces between the Skyrme solitons.Comment: 27 pages amslate

Determination of lunar ilmentite abundances from remotely sensed data

The mapping of ilmenite on the surface of the moon is a necessary precursor to the investigation of prospective lunar base sites. Telescopic observations of the moon using a variety of narrow bandpass optical interference filters are being performed as a preliminary means of achieving this goal. Specifically, ratios of images obtained using filters centered at 0.40 and 0.56 microns provide quantitative estimates of TiO2 abundances. Analysis of preliminary distribution maps of TiO2 concentrations allows identification of specific high-Ti areas. Investigations of these areas using slit spectra in the range 0.03 to 0.85 microns are underway to search for discrete spectral signatures attributable to ilmenite

Another Look at Cord Blood Proteins - Changes with the birth weight and as a predictor of Hyaline membrane disease in neonates

The total cord protein (TCP) and albumin levels of 287 Black babies (155 term and 132 low birthweight) were measured, related to birthweight, and compared with international figures, in order to clarify previously published inconclusive data. An assessment was also made as to whether a previously published level of 4,6 g/100 ml TCP or less, proved of good predictive value to the development of hyaline membrane disease (HMD) in Black babies. TCP levels, as measured by a chemical and meter method, were noted, and the accuracy of the methods compared and statistically evaluated

Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data

Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to utilize a strategy to elicit broadly neutralizing antibodies (bNAbs) that target highly-conserved epitopes. The conserved epitopes of bNAbs have been mapped almost exclusively to the E2 glycoprotein. In this study, we have used HCV-GLUE, a bioinformatics resource for HCV sequence data, to investigate the major epitopes targeted by well-characterized bNAbs. Here, we analyze the level of conservation of each epitope by genotype and subtype and consider the most promising bNAbs identified to date for further study as potential vaccine leads. For the most conserved epitopes, we also identify the most prevalent sequence variants in the circulating HCV population. We examine the distribution of E2 sequence data from across the globe and highlight regions with no coverage. Genotype 1 is the most prevalent genotype worldwide, but in many regions, it is not the dominant genotype. We find that the sequence conservation data is very encouraging; several bNAbs have a high level of conservation across all genotypes suggesting that it may be unnecessary to tailor vaccines according to the geographical distribution of genotypes

Plio-Pleistocene time-averaged field in southern Patagonia recorded in lava flows

Paleomagnetic directions were obtained from stepwise alternating-field or thermal demagnetization of 53 lava flows from southern Patagonia (latitudes 49.5°-52.1 °S) that include the Pali-Aike volcanic field and the Meseta Viscachas plateau lavas. In addition to previous Miocene-late Quaternary ages of these flows, 40Ar/39Ar dates spanning from 0.1 to 15.4 Ma were obtained for 17 of the sites. All except one of the magnetic polarities coincide with the expected polarities of the magnetic polarity timescale [Cande and Kent, 1995] for the obtained 40Ar/39Ar ages. The mean direction from 33 sites (eliminating sites <4 Ma) that pass a selection criteria of α95 ≤5° is Dec = 358.7°,Inc = - 68.2°, α95 = 3.5°, a value that coincides within the statistical uncertainty with the direction of the geocentric axial dipole for that area (Inc = - 68.1°). Likewise, the mean virtual geomagnetic pole (VGP) coincides within the statistical uncertainty with the geographic North Pole. The secular variation described by the VGP angular standard deviation for these sites is 17.1°, a value expected for that latitude according to Model G of paleosecular variation [McFadden et al., 1988]. The characteristics of the data presented are optimum for time-averaged field (TAF) studies because of the good age control and good quality of the paleomagnetic data: (1) primary components of magnetization were obtained using principal component analysis [Kirschvink, 1980] from at least five points and maximum angular deviation ≤5°, (2) site means were calculated with Fisher statistics using at least three samples, and (c) 38 of the 53 flows had α95 ≤ 5°. No results (five sites) or high α95 values (≤5°) were obtained primarily from sites affected by lightning.Fil: Mejia, V.. University of Florida; Estados UnidosFil: Opdyke, N. D.. University of Florida; Estados UnidosFil: Vilas, Juan Francisco A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Singer, B. S.. University of Wisconsin; Estados UnidosFil: Stoner, J. S.. State University of Colorado at Boulder; Estados Unido

How do liquids confined at the nanoscale influence adhesion?

Liquids play an important role in adhesion and sliding friction. They behave as lubricants in human bodies especially in the joints. However, in many biological attachment systems they acts like adhesives, e.g. facilitating insects to move on ceilings or vertical walls. Here we use molecular dynamics to study how liquids confined at the nanoscale influence the adhesion between solid bodies with smooth and rough surfaces. We show that a monolayer of liquid may strongly affect the adhesion.Comment: 5 pages, 9 color figures. Some figures are in Postscript Level 3 format. Minimal changes with respect to the previous version. Added doi and reference to the published article also inside the pape

The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes

Circoviruses (family Circoviridae) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain relatively poorly understood. Endogenous circoviral elements (CVe) are DNA sequences derived from circoviruses that occur in vertebrate genomes. CVe are a useful source of information about the biology and evolution of circoviruses. In this study, we screened 362 vertebrate genome assemblies in silico to generate a catalog of CVe loci. We identified a total of 179 CVe sequences, most of which have not been reported previously. We show that these CVe loci reflect at least 19 distinct germline integration events. We determine the structure of CVe loci, identifying some that show evidence of potential functionalization. We also identify orthologous copies of CVe in snakes, fish, birds, and mammals, allowing us to add new calibrations to the timeline of circovirus evolution. Finally, we observed that some ancient CVe group robustly with contemporary circoviruses in phylogenies, with all sequences within these groups being derived from the same host class or order, implying a hitherto underappreciated stability in circovirus-host relationships. The openly available dataset constructed in this investigation provides new insights into circovirus evolution, and can be used to facilitate further studies of circoviruses and CVe

Additional evidence that juvenile oyster disease is caused by a member of the roseobacter group and colonization of nonaffected animals by stappia stellulata-like strains

Juvenile oyster disease (JOD) causes significant annual mortalities of hatchery-produced Eastern oysters, Crassostrea virginica, cultured in the Northeast. We have reported that a novel species of the α-proteobacteria Roseobacter group (designated CVSP) was numerically dominant in JOD-affected animals sampled during the 1997 epizootic on the Damariscotta River, Maine. In this study we report the isolation of CVSP bacteria from JOD-affected oysters during three separate epizootics in 1998. These bacteria were not detected in nonaffected oysters at the enzootic site, nor in animals raised at a JOD-free site. Animals raised at the JOD enzootic site that were unaffected by JOD were stably and persistently colonized by Stappia stellulata-like strains. These isolates (designated M1) inhibited the growth of CVSP bacteria in a disk-diffusion assay and thus may have prevented colonization of these animals by CVSP bacteria in situ. Laboratory-maintained C. virginica injected with CVSP bacteria experienced statistically significant elevated mortalities compared to controls, and CVSP bacteria were recovered from these animals during the mortality events. Together, these results provide additional evidence that CVSP bacteria are the etiological agent of JOD. Further, there are no other descriptions of specific marine α-proteobacteria that have been successfully cultivated from a defined animal host. Thus, this system presents an opportunity to investigate both bacterial and host factors involved in the establishment of such associations and the role of the invertebrate host in the ecology of these marine α-proteobacteria

Theory of friction: contribution from fluctuating electromagnetic field

We calculate the friction force between two semi-infinite solids in relative parallel motion (velocity $V$), and separated by a vacuum gap of width $d$. The friction force result from coupling via a fluctuating electromagnetic field, and can be considered as the dissipative part of the van der Waals interaction. We consider the dependence of the friction force on the temperature $T$, and present a detailed discussion of the limiting cases of small and large $V$ and $d$.Comment: 15 pages, No figure