Ariel - Volume 10 Number 6

Executive Editors Madalyn Schaefgen David Reich Business Manager David Reich News Editors Medical College Edward Zurad CAHS John Guardiani World Mark Zwanger Features Editors Meg Trexler Jim O\u27Brien Editorials Editor Jeffrey Banyas Photography and Sports Editor Stuart Singer Commons Editor Brenda Peterso

The economic implications of HLA matching in cadaveric renal transplantation.

Abstract Background: The potential economic effects of the allocation of cadaveric kidneys on the basis of tissue-matching criteria are controversial. We analyzed the economic costs associated with the transplantation of cadaveric kidneys with various numbers of HLA mismatches and examined the potential economic benefits of a local, as compared with a national, system designed to minimize HLA mismatches between donor and recipient in first cadaveric renal transplantations. Methods: All data were supplied by the U.S. Renal Data System. Data on all payments made by Medicare from 1991 through 1997 for the care of recipients of a first cadaveric renal transplant were analyzed according to the number of HLA-A, B, and DR mismatches between donor and recipient and the duration of cold ischemia before transplantation. Results: Average Medicare payments for renal-transplant recipients in the three years after transplantation increased from $60,436 per patient for fully HLA-matched kidneys (those with no HLA-A, B, or DR mismatches) to$80,807 for kidneys with six HLA mismatches between donor and recipient, a difference of 34 percent (P\u3c0.001). By three years after transplantation, the average Medicare payments were $64,119 for transplantations of kidneys with less than 12 hours of cold-ischemia time and$74,997 for those with more than 36 hours (P\u3c0.001). In simulations, the assignment of cadaveric kidneys to recipients by a method that minimized HLA mismatching within a local geographic area (i.e., within one of the approximately 50 organ-procurement organizations, which cover widely varying geographic areas) produced the largest cost savings ($4,290 per patient over a period of three years) and the largest improvements in the graft-survival rate (2.3 percent) when the potential costs of longer cold-ischemia time were considered. Conclusions: Transplantation of better-matched cadaveric kidneys could have substantial economic advantages. In our simulations, HLA-based allocation of kidneys at the local level produced the largest estimated cost savings, when the duration of cold ischemia was taken into account. No additional savings were estimated to result from a national allocation program, because the additional costs of longer cold-ischemia time were greater than the advantages of optimizing HLA matching

Health impact assessment of industrial development projects: a spatio-temporal visualization

Development and implementation of large-scale industrial projects in complex eco-epidemiological settings typically require combined environmental, social and health impact assessments. We present a generic, spatio-temporal health impact assessment (HIA) visualization, which can be readily adapted to specific projects and key stakeholders, including poorly literate communities that might be affected by consequences of a project. We illustrate how the occurrence of a variety of complex events can be utilized for stakeholder communication, awareness creation, interactive learning as well as formulating HIA research and implementation questions. Methodological features are highlighted in the context of an iron ore development in a rural part of Afric

The Environment of Warm-Season Elevated Thunderstorms Associated with Heavy Rainfall Over the Central United States

Twenty-one warm-season heavy-rainfall events in the central United States produced by mesoscale convective systems (MCSs) that developed above and north of a surface boundary are examined to define the environmental conditions and physical processes associated with these phenomena. Storm-relative composites of numerous kinematic and thermodynamic fields are computed by centering on the heavy-rain-producing region of the parent elevated MCS. Results reveal that the heavy-rain region of elevated MCSs is located on average about 160 km north of a quasi-stationary frontal zone, in a region of low-level moisture convergence that is elongated westward on the cool side of the boundary. The MCS is located within the left-exit region of a south-southwesterly lowlevel jet (LLJ) and the right-entrance region of an upper-level jet positioned well north of the MCS site. The LLJ is directed toward a divergence maximum at 250 hPa that is coincident with the MCS site. Near-surface winds are light and from the southeast within a boundary layer that is statically stable and cool. Winds veer considerably with height (about 1408) from 850 to 250 hPa, a layer associated with warm-air advection. The MCS is located in a maximum of positive equivalent potential temperature ue advection, moisture convergence, and positive thermal advection at 850 hPa. Composite fields at 500 hPa show that the MCS forms in a region of weak anticyclonic curvature in the height field with marginal positive vorticity advection. Even though surfacebased stability fields indicate stable low-level air, there is a layer of convectively unstable air with maximumu e CAPE values of more than 1000 J kg21 in the vicinity of the MCS site and higher values upstream. Maximumu e convective inhibition (CIN) values over the MCS centroid site are small (less than 40 J kg21) while to the south convection is limited by large values of CIN (greater than 60 J kg21). Surface-to-500-hPa composite average relative humidity values are about 70%, and composite precipitable water values average about 3.18 cm (1.25 in.). The representativeness of the composite analysis is also examined. Last, a schematic conceptual model based upon the composite fields is presented that depicts the typical environment favorable for the development of elevated thunderstorms that lead to heavy rainfall

High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris.

Cell membranes represent the "front line" of cellular defense and the interface between a cell and its environment. To determine the range of proteins and protein complexes that are present in the cell membranes of a target organism, we have utilized a "tagless" process for the system-wide isolation and identification of native membrane protein complexes. As an initial subject for study, we have chosen the Gram-negative sulfate-reducing bacterium Desulfovibrio vulgaris. With this tagless methodology, we have identified about two-thirds of the outer membrane- associated proteins anticipated. Approximately three-fourths of these appear to form homomeric complexes. Statistical and machine-learning methods used to analyze data compiled over multiple experiments revealed networks of additional protein-protein interactions providing insight into heteromeric contacts made between proteins across this region of the cell. Taken together, these results establish a D. vulgaris outer membrane protein data set that will be essential for the detection and characterization of environment-driven changes in the outer membrane proteome and in the modeling of stress response pathways. The workflow utilized here should be effective for the global characterization of membrane protein complexes in a wide range of organisms

Pc5 wave power in the quiet‐time plasmasphere and trough: CRRES observations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94876/1/grl26887.pd

Accountability and Transparency of Entrepreneurial Journalism: Unresolved ethical issues in crowdfunded journalism projects

Crowdfunding is a new business model in which journalists rely—and depend—on (micro-) payments by a large number of supporters to finance their reporting. In this form of entrepreneurial journalism the roles of publisher, fundraiser and journalist often overlap. This raises questions about conflicts of interest, accountability and transparency. The article presents the results of selected case studies in four different European countries—Germany (Krautreporter), Italy (Occhidellaguerra), the United Kingdom (Contributoria) and the Netherlands (De Correspondent)—as well as one US example (Kickstarter). The study used a two-step methodological approach: first a content analysis of the websites and the Twitter accounts with regard to practices of media accountability, transparency and user participation was undertaken. The aim was to investigate how far ethical challenges in crowdfunded entrepreneurial journalism are accounted for. Second, we present findings from semi-structured interviews with journalists from each crowdfunding. The study provides evidence about the ethical issues in this area, particularly in relation to production transparency and responsiveness. The study also shows that in some cases of crowdfunding (platforms), accountability is outsourced and implemented only through the audience participation

Nighttime Magnetic Perturbation Events Observed in Arctic Canada: 3. Occurrence and Amplitude as Functions of Magnetic Latitude, Local Time, and Magnetic Disturbance Indices

Rapid changes of magnetic fields associated with nighttime magnetic perturbation events (MPEs) with amplitudes |ΔB| of hundreds of nT and 5–10 min duration can induce geomagnetically induced currents (GICs) that can harm technological systems. This study compares the occurrence and amplitude of nighttime MPEs with |dB/dt| ≥ 6 nT/s observed during 2015 and 2017 at five stations in Arctic Canada ranging from 64.7° to 75.2° in corrected geomagnetic latitude (MLAT) as functions of magnetic local time (MLT), the SME (SuperMAG version of AE) and SYM/H magnetic indices, and time delay after substorm onsets. Although most MPEs occurred within 30 min after a substorm onset, ∼10% of those observed at the four lower latitude stations occurred over two hours after the most recent onset. A broad distribution in local time appeared at all five stations between 1700 and 0100 MLT, and a narrower distribution appeared at the lower latitude stations between 0200 and 0700 MLT. There was little or no correlation between MPE amplitude and the SYM/H index; most MPEs at all stations occurred for SYM/H values between −40 and 0 nT. SME index values for MPEs observed \u3e1 h after the most recent substorm onset fell in the lower half of the range of SME values for events during substorms, and dipolarizations in synchronous orbit at GOES 13 during these events were weaker or more often nonexistent. These observations suggest that substorms are neither necessary nor sufficient to cause MPEs, and hence predictions of GICs cannot focus solely on substorms

Robot rights? Towards a social-relational justification of moral consideration \ud

Should we grant rights to artificially intelligent robots? Most current and near-future robots do not meet the hard criteria set by deontological and utilitarian theory. Virtue ethics can avoid this problem with its indirect approach. However, both direct and indirect arguments for moral consideration rest on ontological features of entities, an approach which incurs several problems. In response to these difficulties, this paper taps into a different conceptual resource in order to be able to grant some degree of moral consideration to some intelligent social robots: it sketches a novel argument for moral consideration based on social relations. It is shown that to further develop this argument we need to revise our existing ontological and social-political frameworks. It is suggested that we need a social ecology, which may be developed by engaging with Western ecology and Eastern worldviews. Although this relational turn raises many difficult issues and requires more work, this paper provides a rough outline of an alternative approach to moral consideration that can assist us in shaping our relations to intelligent robots and, by extension, to all artificial and biological entities that appear to us as more than instruments for our human purpose