647 research outputs found
Estudio de la viabilidad comercial para la creación de un spa para hombres de 25 a 59 años en la ciudad de Chiclayo, 2015
La presente tesis tuvo como objetivo principal investigar la viabilidad comercial de implementar un Spa exclusivamente para hombres en la ciudad de Chiclayo, debido a que diversos estudios indicaron que en la actualidad los índices de estrés, ya sea laboral o psicológico, son elevados y se requiere desarrollar modelos de negocio que permitan atenuarlos. Por ello, la presente investigación, basándose en una segmentación que abarca hombres de 25 a 59 años, de estilos de vida sofisticados y progresistas, realizó mediante encuestas, entrevistas y grupos focales, un estudio para verificar la viabilidad de ejecución del spa masculino, del cual se obtuvo resultados positivos con respecto al crecimiento de éste sector, demostrando la aceptación del proyecto como parte del cuidado masculino, de modo que éste pueda brindar un servicio innovador, exclusivo y necesario, que ayude a mejorar la calidad de vida y satisfacción de los clientes, a través de las preferencias, características y sugerencias recolectadas en el estudio y análisis del mercado Chiclayano, por lo que se concluyó del estudio que sí es viable la creación de un spa para hombres en dicha ciudad.Tesi
The Schistosomiasis Research Agenda—What Now?
[Extract] As relatively new schistosomiasis researchers, we awaited with eagerness the publication of the "Schistosomiasis Research Agenda" SRA) put forward by Colley and Secor in the December 2007 issue of PLoS Neglected Tropical Diseases [1]. The SRA is a comprehensive, well-organized list of research activities that reflects the impressive diversity of interests that make up current schistosomiasis research. Colley and Secor went to admirable lengths to solicit the interests of researchers the world over, with special efforts to solicit the opinions of scientists in countries or regions where schistosomiasis is endemic, such as Brazil, China, and Africa. Having attended some of these meetings (11th International Congress of Parasitology, held in Glasgow, United Kingdom in August 2006; and the 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene, held in Atlanta, United States in November 2006) and received the emails, we are confident that the SRA indeed reflects the richness and breadth of current schistosomiasis research
Ghostwriting at Elite Academic Medical Centers in the United States
Jeffrey Lacasse and Jonathan Leo assess ghostwriting policies at 50 academic medical centers in the United States and find that only 10 explicitly prohibit ghostwriting
A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation
Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) cell differentiation of antigen-stimulated CD4(+) T cells. Intriguingly, we found that Bcl6 was also highly and transiently expressed during the CD4(+)CD8(+) (double positive [DP]) stage of T cell development, in association with the E3 ligase cullin 3 (Cul3), a novel binding partner of Bcl6 which ubiquitinates histone proteins. DP stage-specific deletion of the E3 ligase Cul3, or of Bcl6, induced the derepression of the Bcl6 target genes Batf (basic leucine zipper transcription factor, ATF-like) and Bcl6, in part through epigenetic modifications of CD4(+) single-positive thymocytes. Although they maintained an apparently normal phenotype after emigration, they expressed increased amounts of Batf and Bcl6 at basal state and produced explosive and prolonged Tfh responses upon subsequent antigen encounter. Ablation of Cul3 in mature CD4(+) splenocytes also resulted in dramatically exaggerated Tfh responses. Thus, although previous studies have emphasized the essential role of Bcl6 in inducing Tfh responses, our findings reveal that Bcl6-Cul3 complexes also provide essential negative feedback regulation during both thymocyte development and T cell activation to restrain excessive Tfh responses
The Sputum Microbiome, Airway Inflammation and Mortality in Chronic Obstructive Pulmonary Disease
Exact Bayesian curve fitting and signal segmentation.
We consider regression models where the underlying functional relationship between the response and the explanatory variable is modeled as independent linear regressions on disjoint segments. We present an algorithm for perfect simulation from the posterior distribution of such a model, even allowing for an unknown number of segments and an unknown model order for the linear regressions within each segment. The algorithm is simple, can scale well to large data sets, and avoids the problem of diagnosing convergence that is present with Monte Carlo Markov Chain (MCMC) approaches to this problem. We demonstrate our algorithm on standard denoising problems, on a piecewise constant AR model, and on a speech segmentation problem
Vasopressin versus norepinephrine infusion in patients with septic shock
Background Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors
Improved Standardization of Type II-P Supernovae: Application to an Expanded Sample
In the epoch of precise and accurate cosmology, cross-confirmation using a
variety of cosmographic methods is paramount to circumvent systematic
uncertainties. Owing to progenitor histories and explosion physics differing
from those of Type Ia SNe (SNe Ia), Type II-plateau supernovae (SNe II-P) are
unlikely to be affected by evolution in the same way. Based on a new analysis
of 17 SNe II-P, and on an improved methodology, we find that SNe II-P are good
standardizable candles, almost comparable to SNe Ia. We derive a tight Hubble
diagram with a dispersion of 10% in distance, using the simple correlation
between luminosity and photospheric velocity introduced by Hamuy & Pinto 2002.
We show that the descendent method of Nugent et al. 2006 can be further
simplified and that the correction for dust extinction has low statistical
impact. We find that our SN sample favors, on average, a very steep dust law
with total to selective extinction R_V<2. Such an extinction law has been
recently inferred for many SNe Ia. Our results indicate that a distance
measurement can be obtained with a single spectrum of a SN II-P during the
plateau phase combined with sparse photometric measurements.Comment: ApJ accepted version. Minor change
Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis
Cullin 3 (CUL3) is part of the ubiquitin proteasomal system and controls several cellular processes critical for normal organ function including the cell cycle, and Keap1/Nrf2 signaling. Kidney tubule-specific Cul3 disruption causes tubulointerstitial fibrosis, but little is known about the mechanisms. Therefore, we tested the hypothesis that dysregulation of the cell cycle and Keap1/Nrf2 pathway play a role in initiating the kidney injury upon Cul3 disruption. Cul3 deletion increased expression of cyclin E and p21, associated with uncontrolled proliferation, DNA damage, and apoptosis, all of which preceded proximal tubule injury. The cdk2-cyclin E inhibitor roscovitine did not prevent the effects of Cul3 deletion, but instead exacerbated the kidney injury. Injury occurred despite accumulation and activation of CUL3 substrate Keap1/Nrf2, proposed to be protective in kidney injury. Cul3 disruption led to progressive interstitial inflammation, functionally relevant renal fibrosis and death. Finally, we observed reduced CUL3 expression in several AKI and CKD mouse models and in fibrotic human kidney tissue. These data establish CUL3 knockout mice as a novel genetic CKD model in which dysregulation of the cell cycle may play a primary role in initiating tubule injury, and that CUL3 dysregulation could contribute to acute and fibrotic kidney disease
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