2,184 research outputs found
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A systematic review of the psychological correlates of adjustment outcomes in adults with inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic long term condition which poses significant psychosocial adjustment challenges. The purpose of this review was to systematically identify psychological factors related to adjustment in adults with IBD with the aim of suggesting evidence based targets that may be modifiable though psychological intervention. Twenty five studies met inclusion criteria and were included in the systematic review and a narrative synthesis was conducted. A wide range of psychological variables were addressed covering six broad categories; personality traits, interpersonal traits, stress and coping, emotions and emotional control, IBD related cognitions and non IBD related cognitions. The most consistent relationship was found between certain emotion focused coping strategies and worse adjustment outcomes in IBD. Some evidence also hi-lighted a relationship between personality traits (such as neuroticism,) perceived stress, emotions and emotional control (such as alexithymia) and IBD related cognitions (such as illness perceptions) and negative adjustment outcomes. The results of this review suggest that interventions to improve adjustment in IBD may benefit from a focus on coping strategies, perceived stress and IBD related cognitions
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COPe-support - a multi-component digital intervention for family carers for people affected by psychosis: study protocol for a randomized controlled trial.
BACKGROUND: Psychosis often causes significant distress and impacts not only in the individuals, but also those close to them. Many relatives and friends ('carers') provide long-term support and need resources to assist them. We have co-produced a digital mental health intervention called COPe-support (Carers fOr People with Psychosis e-support) to provide carers with flexible access to high quality psychoeducation and interactive support from experts and peers. This study evaluates the effectiveness of COPe-support to promote mental wellbeing and caregiving experiences in carers. METHODS: This study is a single-blind, parallel arm, individually randomized controlled trial (RCT) comparing COPe-support, with attention control. Both groups continue to receive usual care. COPe-support provides interactive web-based psychoeducation on psychosis-related issues, wellbeing-promotion and network support through forums. The attention-control is a non-interactive online information resource pack. Carers living in England are eligible if they provide at least weekly support to a family member or close friend affected by psychosis, and use internet communication (including emails) daily. All trial procedures are run online, including collection of outcome measurements which participants will directly input into our secure platform. Following baseline assessment, a web-based randomization system will be used to allocate 360 carers to either arm. Participants have unlimited access to the allocated condition for 40âweeks. Data collection is at three time points (10, 20, and 40âweeks after randomization). Analyses will be conducted by trial statisticians blinded to allocation. The primary outcome is mental wellbeing measured by Warwick Edinburgh Mental Wellbeing Scale (WEMWBS), at 20âweeks. As well as an intention-to-treat analysis, a complier average causal effect (CACE) analysis will be conducted to estimate the intervention effect in participants who have accessed COPe-support content twice or more. The secondary objectives and analysis will examine other health and caregiving-related outcomes and explore mechanisms. In a process evaluation, we will interview 20% of the intervention arm participants regarding the acceptability of COPe-support. We will explore in detail participants' usage patterns. DISCUSSION: The results of this trial will provide valuable information about the effectiveness of COPe-support in promoting wellbeing and caregiving experiences in carers. TRIAL REGISTRATION: The RCT is registered with the Current Controlled Trials registration (ISRCTN 89563420, registration date: 02/03/2018)
The Dropping of In-Medium Hadron Mass in Holographic QCD
We study the baryon density dependence of the vector meson spectrum using the
D4/D6 system together with the compact D4 baryon vertex. We find that the
vector meson mass decreases almost linearly in density at low density for small
quark mass, but saturates to a finite non-zero value for large density. We also
compute the density dependence of the mass and the
velocity. We find that in medium, our model is consistent with the GMOR
relation up to a few times the normal nuclear density. We compare our hQCD
predictions with predictions made based on hidden local gauge theory that is
constructed to model QCD.Comment: 20 pages, 7 figure
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The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically. Due to the role of Th17 cells in autoimmune pathogenesis, it is important to understand the factors that control Th17 development. Here we identify the activating transcription factor 7 interacting protein (ATF7ip) as a critical regulator of Th17 differentiation. Mice with T cell-specific deletion of Atf7ip have impaired Th17 differentiation secondary to the aberrant overproduction of IL-2 with T cell receptor (TCR) stimulation and are resistant to colitis in vivo. ChIP-seq studies identified ATF7ip as an inhibitor of Il2 gene expression through the deposition of the repressive histone mark H3K9me3 in the Il2-Il21 intergenic region. These results demonstrate a new epigenetic pathway by which IL-2 production is constrained, and this may open up new avenues for modulating its production
A general approach to quenching and galactic conformity
We develop a conceptual framework and methodology to study the drivers of the
quenching of galaxies, including the drivers of galactic conformity. The
framework is centred on the statistic , which is defined as the
difference between the observed star-formation state of a galaxy, and a
prediction of its state based on an empirical model of quenching. In
particular, this work uses the average quenching effects of stellar mass and
local density to construct an empirical model of quenching. is
therefore a residual which reflects the effects of drivers of quenching not
captured by stellar mass and local density, or so-called 'hidden variables'.
Through a toy model, we explore how the statistical properties of can
be used to learn about the internal and external hidden variables which control
the quenching of a sample of galaxies. We then apply this analysis to a sample
of local galaxies and find that, after accounting for the average quenching
effects of stellar mass and local density, remains correlated out to
separations of 3 Mpc. Furthermore, we find that external hidden variables
remain important for driving the residual quenching of low-mass galaxies, while
the residual quenching of high-mass galaxies is driven mostly by internal
properties. These results, along with a similar analysis of a semi-analytical
mock catalogue, suggest that it is necessary to consider halo-related
properties as candidates for hidden variables. A preliminary halo-based
analysis indicates that much of the correlation of can be attributed
to the physics associated with individual haloes.Comment: 19 pages, 11 figures, submitted to MNRA
Exploring the multi-humped fission barrier of 238U via sub-barrier photofission
The photofission cross-section of 238U was measured at sub-barrier energies
as a function of the gamma-ray energy using, for the first time, a
monochromatic, high-brilliance, Compton-backscattered gamma-ray beam. The
experiment was performed at the High Intensity gamma-ray Source (HIgS) facility
at beam energies between E=4.7 MeV and 6.0 MeV and with ~3% energy resolution.
Indications of transmission resonances have been observed at gamma-ray beam
energies of E=5.1 MeV and 5.6 MeV with moderate amplitudes. The triple-humped
fission barrier parameters of 238U have been determined by fitting EMPIRE-3.1
nuclear reaction code calculations to the experimental photofission cross
section.Comment: 5 pages, 3 figure
Spacetime Fermions in Light-cone Gauge Superstring Field Theory and Dimensional Regularization
We consider the dimensional regularization of the light-cone gauge type II
superstring field theories in the NSR formalism. In the previous work, we have
calculated the tree-level amplitudes with external lines in the (NS,NS) sector
using the regularization and shown that the desired results are obtained
without introducing contact term interactions. In this work, we study the
tree-level amplitudes with external lines in the Ramond sector. In order to
deal with them, we propose a worldsheet theory to be used instead of that for
the naive dimensional regularization. With the worldsheet theory, we regularize
and define the tree-level amplitudes by analytic continuation. We show that the
results coincide with those of the first quantized formulation.Comment: 28 pages, 5 figures; v2: more details of our manipulations in
subsection 3.2 added, figures and references added; v3: clarifications adde
Flowing Between Fermionic Fixed Points
We study holographic Wilsonian renormalization group flows for bulk spinor
fields in AdS. We use this to compute the all-loop beta function for fermionic
double trace operators in the dual conformal field theory.Comment: 21 pages. V2: Acknowledgement added; v3: Typo correcte
Mixed RG Flows and Hydrodynamics at Finite Holographic Screen
We consider quark-gluon plasma with chemical potential and study
renormalization group flows of transport coefficients in the framework of
gauge/gravity duality. We first study them using the flow equations and compare
the results with hydrodynamic results by calculating the Green functions on the
arbitrary slice. Two results match exactly. Transport coefficients at arbitrary
scale is ontained by calculating hydrodynamics Green functions. When either
momentum or charge vanishes, transport coefficients decouple from each other.Comment: 22 pages, 6 figure
Holographic Superconductor for a Lifshitz fixed point
We consider the gravity dual of strongly coupled system at a Lifshitz-fixed
point and finite temperature, which was constructed in a recent work
arXiv:0909.0263. We construct an Abelian Higgs model in that background and
calculate condensation and conductivity using holographic techniques. We find
that condensation happens and DC conductivity blows up when temperature turns
below a critical value.Comment: 14 pages, 4 figures, v4: improved version, references adde
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