Real-time growth rate for general stochastic SIR epidemics on unclustered networks

Networks have become an important tool for infectious disease epidemiology. Most previous theoretical studies of transmission network models have either considered simple Markovian dynamics at the individual level, or have focused on the invasion threshold and final outcome of the epidemic. Here, we provide a general theory for early real-time behaviour of epidemics on large configuration model networks (i.e. static and locally unclustered), in particular focusing on the computation of the Malthusian parameter that describes the early exponential epidemic growth. Analytical, numerical and Monte-Carlo methods under a wide variety of Markovian and non-Markovian assumptions about the infectivity profile are presented. Numerous examples provide explicit quantification of the impact of the network structure on the temporal dynamics of the spread of infection and provide a benchmark for validating results of large scale simulations.Comment: 45 pages, 8 figures, submitted to Mathematical Biosciences on 29/11/2014; Version 2: resubmitted on 15/04/2015; accepted on 17/04/2015. Changes: better explanations in introduction; restructured section 3.3 (3.3.3 added); section 6.3.1 added; more precise terminology; typos correcte

On the Hierarchical Preconditioning of the Combined Field Integral Equation

This paper analyzes how hierarchical bases preconditioners constructed for the Electric Field Integral Equation (EFIE) can be effectively applied to the Combined Field Integral Equation (CFIE). For the case where no hierarchical solenoidal basis is available (e.g., on unstructured meshes), a new scheme is proposed: the CFIE is implicitly preconditioned on the solenoidal Helmholtz subspace by using a Helmholtz projector, while a hierarchical non-solenoidal basis is used for the non-solenoidal Helmholtz subspace. This results in a well-conditioned system. Numerical results corroborate the presented theory

Assumptions that imply quantum dynamics is linear

A basic linearity of quantum dynamics, that density matrices are mapped linearly to density matrices, is proved very simply for a system that does not interact with anything else. It is assumed that at each time the physical quantities and states are described by the usual linear structures of quantum mechanics. Beyond that, the proof assumes only that the dynamics does not depend on anything outside the system but must allow the system to be described as part of a larger system. The basic linearity is linked with previously established results to complete a simple derivation of the linear Schrodinger equation. For this it is assumed that density matrices are mapped one-to-one onto density matrices. An alternative is to assume that pure states are mapped one-to-one onto pure states and that entropy does not decrease.Comment: 10 pages. Added references. Improved discussion of equations of motion for mean values. Expanded Introductio

Organic small molecule field-effect transistors with Cytop(TM) gate dielectric: eliminating gate bias stress effects

We report on organic field-effect transistors with unprecedented resistance against gate bias stress. The single crystal and thin-film transistors employ the organic gate dielectric Cytop(TM). This fluoropolymer is highly water repellent and shows a remarkable electrical breakdown strength. The single crystal transistors are consistently of very high electrical quality: near zero onset, very steep subthreshold swing (average: 1.3 nF V/(dec cm2)) and negligible current hysteresis. Furthermore, extended gate bias stress only leads to marginal changes in the transfer characteristics. It appears that there is no conceptual limitation for the stability of organic semiconductors in contrast to hydrogenated amorphous silicon.Comment: 4 pages, 3 figures, to be published in Appl. Phys. Let

Astex microgravity experiment: simulated asteroid regoliths

AstEx is a microgravity experiment selected to fly on ESA's 51st Microgravity Research Campaign in November 2009. The experiment will investigate the dynamics of regolith on asteroid surfaces. Despite their very low surface gravities, asteroids exhibit a number of different geological processes involving granular matter. Understanding the mechanical response of this granular material subject to external forces in microgravity conditions is vital to the design of a successful asteroid sub-surface sampling mechanism, and in the interpretation of the fascinating geology on an asteroid. The AstEx experiment uses a microgravity modified Taylor-Couette shear cell to investigate granular flow caused by shear forces under the conditions of parabolic flight microgravity. It is intended to determine how a steady state granular flow is achieved in microgravity conditions, and what effect prior shear history has on the timescales involved in initiating a steady state flow in a granular material. Presented are the technical details of the AstEx experimental design with particular emphasis on how the team have designed the equipment specifically for the parabolic flight microgravity environment

Longitudinal Spin Asymmetry and Cross Section of Inclusive pi0 Production in Polarized p+p Collisions at RHIC

We present the first measurement of the cross section and the double longitudinal spin asymmetry of inclusive pi0 production in polarized p+p collisions at Sqrt(s) = 200 GeV at mid-rapidity with the STAR detector, using the barrel electromagnetic calorimeter. The measured cross section is compared to NLO pQCD calculations and can provide constraints on the pion fragmentation functions. Fragmentation is studied directly by measuring the momentum fraction of pi0 in jets, a quantity that is affected by the fragmentation process and jet reconstruction effects. The double longitudinal spin asymmetry is compared to NLO pQCD calculations based on different assumptions for the gluon polarization in the nucleon to provide constraints on delta g/g. At the present level of statistics the measured asymmetry disfavors a large positive gluon polarization, but can not yet distinguish between other scenarios.Comment: 4 pages, 2 figures, submitted to the proceedings of the 17th International Spin Physics Symposium (SPIN2006), Kyoto, Japan, October 2 to 7, 200

Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodeling of IP₃Rs isoform composition and ER luminal Ca²⁺ levels in colorectal cancer cell lines

The GTPase Ras is a molecular switch engaged downstream of G-protein coupled receptors and receptor tyrosine inases that controls multiple cell fate-determining signalling athways. Ras signalling is frequently deregulated in cancer underlying associated changes in cell phenotype. Although Ca2+ signalling pathways control some overlapping functions with Ras, and altered Ca2+ signalling pathways are emerging as important players in oncogenic transformation, how Ca2+ signalling is remodelled during transformation and whether it has a causal role remains unclear. We have investigated Ca2+ signalling in two human colorectal cancer cell lines and their isogenic derivatives in which the mutated K-Ras allele (G13D) has been deleted by homologous recombination. We show that agonist-induced Ca2+ release from intracellular stores is enhanced by loss of K-RasG13D through an increase in the ER store content and a modification of IP3R subtype abundance. Consistently, uptake of Ca2+ into mitochondria and sensitivity to apoptosis was enhanced as a result of KRasG13D loss. These results suggest that suppression of Ca2+ signalling is a common response to naturally occurring levels of K-RasG13D that contributes to a survival advantage during oncogenic transformation

Discovery-led refinement in e-discovery investigations: sensemaking, cognitive ergonomics and system design.

Given the very large numbers of documents involved in e-discovery investigations, lawyers face a considerable challenge of collaborative sensemaking. We report findings from three workplace studies which looked at different aspects of how this challenge was met. From a sociotechnical perspective, the studies aimed to understand how investigators collectively and individually worked with information to support sensemaking and decision making. Here, we focus on discovery-led refinement; specifically, how engaging with the materials of the investigations led to discoveries that supported refinement of the problems and new strategies for addressing them. These refinements were essential for tractability. We begin with observations which show how new lines of enquiry were recursively embedded. We then analyse the conceptual structure of a line of enquiry and consider how reflecting this in e-discovery support systems might support scalability and group collaboration. We then focus on the individual activity of manual document review where refinement corresponded with the inductive identification of classes of irrelevant and relevant documents within a collection. Our observations point to the effects of priming on dealing with these efficiently and to issues of cognitive ergonomics at the human–computer interface. We use these observations to introduce visualisations that might enable reviewers to deal with such refinements more efficiently

Metagenetic analysis of patterns of distribution and diversity of marine meiobenthic eukaryotes

AimMeiofaunal communities that inhabit the marine benthos offer unique opportunities to simultaneously study the macroecology of numerous phyla that exhibit different life-history strategies. Here, we ask: (1) if the macroecology of meiobenthic communities is explained mainly by dispersal constraints or by environmental conditions; and (2) if levels of meiofaunal diversity surpass existing estimates based on morphological taxonomy. LocationUK and mainland European coast. MethodsNext-generation sequencing techniques (NGS; Roche 454 FLX platform) using 18S nuclear small subunit ribosomal DNA (rDNA) gene. Pyrosequences were analysed using AmpliconNoise followed by chimera removal using Perseus. ResultsRarefaction curves revealed that sampling saturation was only reached at 15% of sites, highlighting that the bulk of meiofaunal diversity is yet to be discovered. Overall, 1353 OTUs were recovered and assigned to 23 different phyla. The majority of sampled sites had c. 60-70 unique operational taxonomic units (OTUs) per site, indicating high levels of beta diversity. The environmental parameters that best explained community structure were seawater temperature, geographical distance and sediment size, but most of the variability (R-2=70%-80%) remains unexplained. Main conclusionsHigh percentages of endemic OTUs suggest that meiobenthic community composition is partly niche-driven, as observed in larger organisms, but also shares macroecological features of microorganisms by showing high levels of cosmopolitanism (albeit on a much smaller scale). Meiobenthic communities exhibited patterns of isolation by distance as well as associations between niche, latitude and temperature, indicating that meiobenthic communities result from a combination of niche assembly and dispersal processes. Conversely, isolation-by-distance patterns were not identified in the featured protists, suggesting that animals and protists adhere to radically different macroecological processes, linked to life-history strategies.Natural Environment Research Council (NERC) [NE/E001505/1, NE/F001266/1, MGF-167]; Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/27413/2006, SFRH/BPD/80447/2014]; EPSRC [EP/H003851/1]; BBSRC CASE studentship; Unilever; Biotechnology and Biological Sciences Research Council [987347]; Engineering and Physical Sciences Research Council [EP/H003851/1]; Natural Environment Research Council [NE/F001290/1, NE/F001266/1, NE/E001505/1, NBAF010002]info:eu-repo/semantics/publishedVersio

Corrections and Comments on the Multipole Moments of Axisymmetric Electrovacuum Spacetimes

Following the method of Hoenselaers and Perj\'{e}s we present a new corrected and dimensionally consistent set of multipole gravitational and electromagnetic moments for stationary axisymmetric spacetimes. Furthermore, we use our results to compute the multipole moments, both gravitational and electromagnetic, of a Kerr-Newman black hole.Comment: This is a revised and corrected versio