Lateglacial to Mid-Holocene Vegetation History in the Eastern Vale of Pickering, Northeast Yorkshire, UK: Pollen Diagrams from Palaeolake Flixton

Palaeolake Flixton, in the eastern Vale of Pickering in northeast Yorkshire, UK, existed as open water during the Lateglacial and early to mid-Holocene, until hydroseral succession and gradual terrestrialisation changed it to an area of fen and basin peatland by the later mid-Holocene. The environs of the lake were occupied by Late Palaeolithic and Mesolithic people over thousands of years and many Early Mesolithic sites, in particular, have been found located along the ancient lake edge, including the paradigm site for the British Early Mesolithic at Star Carr, where occupation occurred over several centuries. We have analysed eleven sediment cores, distributed in most parts of the palaeolake area, for pollen and stratigraphic data with which to reconstruct lake development and vegetation history. These new diagrams augment earlier pollen studies from the western part of the lake, particularly in the Star Carr area and near other major Mesolithic sites around Seamer Carr. Especially informative are a long core from the deepest part of the lake; cores that document the Lateglacial as well as early Holocene times, and evidence for the later Mesolithic that helps to balance the high density of Late Mesolithic sites known from research in the adjacent uplands of the North York Moors. There are many records of charcoal in the deposits but, especially for the earliest examples, it is not always possible to tie them firmly to either human activity or natural causes. Overall, the new and previously existing diagrams provide evidence for the spatial reconstruction of vegetation history across this important wetland system, including (a) for the progression of natural community successions within the wetland and on the surrounding dryland (b) the influence of climate change in bringing about changes in woodland composition and (c) for discussion of the possibility of human manipulation of the vegetation in the Late Upper Palaeolithic, Early and Late Mesolithic. Results show that climate was the main driver of longer-term vegetation change. Centennial-scale, abrupt climate events caused significant vegetation reversals in the Lateglacial Interstadial. The Lateglacial vegetation was very similar throughout the lake hinterland, although some areas supported some scrubby shrub rather than being completely open. Immigration and spread of Holocene woodland taxa comprised the familiar tree succession common in northern England but the timings of the establishment and the abundance of some individual tree types varied considerably around the lake margins because of edaphic factors and the effects of fire, probably of human origin. Woodland successions away from proximity to the lake were similar to those recorded in the wider landscape of northern England and produced a dense, homogenous forest cover occasionally affected by fire

The North Carolina Contractual Scholarship Fund program : outcomes, administrative practices, and implications for self regulation for a state-supported student aid program at independent colleges and universities

Since 1972, the State of North Carolina has funded a program of student financial assistance, called the North Carolina Contractual Scholarship Fund (NCCSF), for residents who attend North Carolina private colleges and universities. This study acts as an evaluation of the NCCSF with two purposes: (1) to determine whether the achieved outcomes are the intended of the program; and, (2) to examine NCCSF administrative operations to discover whether there are common practices among the institutions participating in the NCCSF and whether additional initiatives of self regulation are necessary. The evaluation framework contains eight outcome indicators addressing both enrollment and institutional demographics. Data from existing higher education statistics are used in the analysis of outcome indicators. Indicators of administrative process and practice are driven by seven common elements of financial aid administration found in federal Title IV student financial aid programs. These indicators are tested with data assembled by a field survey questionnaire. An action model for securing self-regulation goals is also presented

The location of international practices: what is human rights practice?

This article opens up space to challenge state-centrism about human rights practice. To do so, it presents and critically assesses four methods that can be used to determine who and/or what counts as a part of any international practice: the agreement method, which locates a practice by referring to speech acts that define it; the contextual method, which locates a practice by referring to the actions, meanings, and intentions of practitioners; the value method, which locates a practice by identifying a value or principle that the practice reflects or instantiates; and the purpose method, which locates a practice by constructing an account of the sociopolitical reason(s) for a practice's existence. The purpose method, based on an interpretation of Rawls' constructivism, is developed, in a way that focuses on practitioners' judgement-based reasons to assign responsibility for human rights to any state or non-state actor

Global citizenship as the completion of cosmopolitanism

A conception of global citizenship should not be viewed as separate from, or synonymous with, the cosmopolitan moral orientation, but as a primary component of it. Global citizenship is fundamentally concerned with individual moral requirements in the global frame. Such requirements, framed here as belonging to the category of individual cosmopolitanism, offer guidelines on right action in the context of global human community. They are complementary to the principles of moral cosmopolitanism – those to be used in assessing the justice of global institutions and practices – that have been emphasised by cosmopolitan political theorists. Considering principles of individual and moral cosmopolitanism together can help to provide greater clarity concerning individual duties in the absence of fully global institutions, as well as clarity on individual obligations of justice in relation to emerging and still-developing trans-state institutions

Are CT-derived muscle measurements prognostic, independent of systemic inflammation in good performance status patients with advanced cancer?

The present study examined the relationships between CT-derived muscle measurements, systemic inflammation, and survival in advanced cancer patients with good performance status (ECOG-PS 0/1). Data was collected prospectively from patients with advanced cancer undergoing anti-cancer therapy with palliative intent. The CT Sarcopenia score (CT-SS) was calculated by combining the CT-derived skeletal muscle index (SMI) and density (SMD). The systemic inflammatory status was determined using the modified Glasgow Prognostic Score (mGPS). The primary outcome of interest was overall survival (OS). Univariate and multivariate Cox regressions were used for survival analysis. Three hundred and seven patients met the inclusion criteria, out of which 62% (n = 109) were male and 47% (n = 144) were ≥65 years of age, while 38% (n = 118) were CT-SS ≥ 1 and 47% (n = 112) of patients with pre-study blood were inflamed (mGPS ≥ 1). The median survival from entry to the study was 11.1 months (1–68.1). On univariate analysis, cancer type (p < 0.05) and mGPS (p < 0.001) were significantly associated with OS. On multivariate analysis, only mGPS (p < 0.001) remained significantly associated with OS. In patients who were ECOG-PS 0, mGPS was significantly associated with CT-SS (p < 0.05). mGPS may dominate the prognostic value of CT-derived sarcopenia in good-performance-status patients with advanced cancer

Lactate dehydrogenase: Relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer

Background: Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined. Methods: Prospectively collected data from patients with advanced cancer, undergoing anti-cancer therapy with palliative intent, across nine sites in the UK and Ireland between 2011–2016, was retrospectively analysed. LDH values were grouped as <250/250–500/>500 Units/L. Relationships were examined using χ2 test for linear-by-linear association and binary logistics regression analysis. Results: A total of 436 patients met the inclusion criteria. 46% (n = 200) were male and 59% (n = 259) were ≥65 years of age. The median serum LDH was 394 Units/L and 33.5% (n = 146) had an LDH > 500 Units/L. LDH was significantly associated with ECOG-PS (p < 0.001), NLR (p < 0.05), mGPS (p < 0.05) and 3-month survival (p < 0.001). LDH was significantly associated with 3-month survival independent of weight loss (p < 0.01), BMI (p < 0.05), skeletal muscle mass (p < 0.01), metastatic disease (p < 0.05), NLR (p < 0.05) and mGPS (p < 0.01). Discussion: LDH was associated with performance status, systemic inflammation and survival in patients with advanced cancer. LDH measurement may be considered as an aetiologic criteria and become a potential therapeutic target in the treatment of cancer cachexia

Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose.

BackgroundUnderstanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in investigating fungal degradation during time-points where CAZyme expression peaks. However, a robust understanding of the fungal survival strategies over its life time on lignocellulose is thereby missed. Here we aimed to uncover the physiological responses of the biotechnological workhorse and enzyme producer Aspergillus niger over its life time to six substrates important for biofuel production.ResultsWe analysed the response of A. niger to the feedstock Miscanthus and compared it with our previous study on wheat straw, alone or in combination with hydrothermal or ionic liquid feedstock pretreatments. Conserved (substrate-independent) metabolic responses as well as those affected by pretreatment and feedstock were identified via multivariate analysis of genome-wide transcriptomics combined with targeted transcript and protein analyses and mapping to a metabolic model. Initial exposure to all substrates increased fatty acid beta-oxidation and lipid metabolism transcripts. In a strain carrying a deletion of the ortholog of the Aspergillus nidulans fatty acid beta-oxidation transcriptional regulator farA, there was a reduction in expression of selected lignocellulose degradative CAZyme-encoding genes suggesting that beta-oxidation contributes to adaptation to lignocellulose. Mannan degradation expression was wheat straw feedstock-dependent and pectin degradation was higher on the untreated substrates. In the later life stages, known and novel secondary metabolite gene clusters were activated, which are of high interest due to their potential to synthesize bioactive compounds.ConclusionIn this study, which includes the first transcriptional response of Aspergilli to Miscanthus, we highlighted that life time as well as substrate composition and structure (via variations in pretreatment and feedstock) influence the fungal responses to lignocellulose. We also demonstrated that the fungal response contains physiological stages that are conserved across substrates and are typically found outside of the conditions with high CAZyme expression, as exemplified by the stages that are dominated by lipid and secondary metabolism

The Ursinus Weekly, November 9, 1964

Senior Ball, Friday, offers Camelot, Al Raymond band: Lord and Lady, permanent class officers to be announced • Graduate awards available from science foundation • Miller and Zucker review election returns, meaning • Museum director on American art to be Forum highlight: Dr. Turner to emphasize the 20th century • William Shaffer, vice-president UC Board of Directors, dies • Pancoast in State House to seek greater local power • Faculty action penalizes 4 with fines, demerits • Curtain Club selects cast for Winnie the Pooh production, schedules December showing • English Club to meet tonight • Editorial: Altruism at Ursinus • Life in the cow palace; An eyewitness account • Kaffee Klatsch hosts large crowd to discuss rights • A girl\u27s life at Ursinus: 1906 • Spotlight: UC abroad • Advice column • Bears belt Haverford 19-6 at Haverford homecoming: Tony Motto scores two touchdowns • Soccermen defeat LaSalle 5-2 • Hockey team wins biggest: W.C., best ever, falls 1-0; West Chester places 5 on all-stars, Ursinus team effort proves supreme • Wrestling to start Tuesday • U.C. men\u27s mooning team suffers setback at hands of faculty • 200 dance to Okie Duke at Cafe Montmarte • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1233/thumbnail.jp

The relationship between the BMI-adjusted weight loss grading system and quality of life in patients with incurable cancer

Weight loss (WL) has long been recognized as an important factor associated with reduced quality of life (QoL) and reduced survival in patients with cancer. The body mass index (BMI)-adjusted weight loss grading system (WLGS) has been shown to be associated with reduced survival. However, its impact on QoL has not been established. The aim of this study was to assess the relationship between this WLGS and QoL in patients with advanced cancer. A biobank analysis was undertaken of adult patients with advanced cancer. Data collected included patient demographics, Eastern Cooperative Oncology Group performance status, and anthropometric parameters (BMI and %WL). Patients were categorized according to the BMI-adjusted WLGS into one of five distinct WL grades (grades 0-4). QoL was collected using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30. The Kruskal-Wallis test and multivariate logistic regression analyses were used to assess the relationship between the WLGS and QoL scores. Overall survival was assessed using Kaplan-Meier curve and Cox proportional hazard models. A total of 1027 patients were assessed (51% male, median age: 66 years). Gastrointestinal cancer was most prevalent (40%), and 87% of patients had metastatic disease. Half (58%) of patients had a WL grade of 0-1, while 12%, 20%, and 10% had WL grades of 2, 3, and 4, respectively. Increasing WL grades were significantly associated with poorer QoL functioning and symptoms scales (all P < 0.05). Physical, role, and emotional functioning decreased by a median of >20 points between WL grade 0 and WL grade 4, while appetite loss, pain, dyspnoea, and fatigue increased by a median score >20 points, indicative of a large clinical significant difference. Increasing WL grades were associated with deteriorating QoL summary score. WL grades 2, 3, and 4 were independently associated with a QoL summary score below the median (<77.7) [odds ratio (OR) 1.69, P = 0.034; OR 2.06, P = 0.001; OR 4.29, P < 0.001, respectively]. WL grades 3 and 4 were independently associated with reduced overall survival [hazard ratio 1.54 (95% confidence interval: 1.22-1.93), P < 0.001 and hazard ratio 1.87 (95% confidence interval: 1.42-2.45), P < 0.001, respectively]. Our findings support that the WLGS is useful in identifying patients at risk of poor QoL that deteriorates with increasing WL grades. WL grade 4 is independently associated with a particularly worse prognosis and increased symptom burden. Identification and early referral to palliative care services may benefit these patients