“Las penas con pan duelen menos”: The role of food and culture in Latinas with disordered eating behaviors

This study elucidated the experiences of eighteen Latina adults (mean age = 38.5 years) from “Promoviendo una Alimentación Saludable” Project who received nutritional intervention as part of the clinical trial. Half of the participants were first generation immigrants from Mexico (50%), followed by U.S. born with 16.7%. Remaining nationalities represented were Bolivia, Colombia, Guatemala, Honduras, Peru, and Venezuela with 33.3% combined. The average duration of living in the U.S. was 11.1 years. The mean body mass index (BMI) at baseline was 36.59 kg/m2 (SD=7.72). Based on the DSM-IV, 28% (n=5) participants were diagnosed with binge-eating disorder, 33% (n=6) with bulimia nervosa purging type and 39% (n=7) with eating disorder not otherwise specified. Participants received up to three nutritional sessions; a bilingual dietitian conducted 97.8% of sessions in Spanish. In total, fifty nutritional sessions were included in the qualitative analysis. A three step qualitative analysis was conducted. First, a bilingual research team documented each topic discussed by patients and all interventions conducted by the dietitian. Second, all topics were classified into specific categories and the frequency was documented. Third, a consensus with the dietitian was performed to validate the categories identified by the research team. Six categories (describing eating patterns, emotional distress, Latino culture values, family conflicts associated with disturbed eating behaviors, lack of knowledge of healthy eating, and treatment progress) emerged from patients across all nutritional sessions. Considering the background of immigration and trauma (60%, n=15) in this sample; the appropriate steps of nutritional intervention appear to be: 1) elucidating the connection between food and emotional distress, 2) providing psychoeducation of healthy eating patterns using the plate method, and 3) developing a meal plan

Amplification Properties of Femtosecond Laser-Written Er3+/Yb3+ Doped Waveguides in a Tellurium-Zinc Glass

We report on the fabrication and characterization of active waveguides in a TeO2-ZnO glass sample doped with Er3+/Yb3+ fabricated by direct laser writing with a femtosecond laser delivering 150 fs pulses at 1 kHz repetition rate. The waveguides exhibit an internal gain of 0.6 dB/cm at 1535 nm, thus demonstrating the feasibility of active photonics lightwave circuits and lossless components in such a glass composition

AtUTr1, a UDP-glucose/UDP-galactose transporter from Arabidopsis thaliana, is located in the endoplasmic reticulum and up-regulated by the unfolded protein response

Indexación: Scopus.The folding of glycoproteins in the endoplasmic reticulum (ER) depends on a quality control mechanism mediated by the calnexin/calreticulin cycle. During this process, continuous glucose trimming and UDP-glucose-dependent re-glucosylation of unfolded glycoproteins takes place. To ensure proper folding, increases in misfolded proteins lead to up-regulation of the components involved in quality control through a process known as the unfolded protein response (UPR). Reglucosylation is catalyzed by the ER lumenal located enzyme UDP-glucose glycoprotein glucosyltransferase, but as UDP-glucose is synthesized in the cytosol, a UDP-glucose transporter is required in the calnexin/calreticulin cycle. Even though such a transporter has been hypothesized, no protein playing this role in the ER yet has been identified. Here we provide evidence that AtUTr1, a UDP-galactose/glucose transporter from Arabidopsis thaliana, responds to stimuli that trigger the UPR increasing its expression around 9-fold. The accumulation of AtUTr1 transcript is accompanied by an increase in the level of the AtUTr1 protein. Moreover, subcellular localization studies indicate that AtUTr1 is localized in the ER of plant cells. We reasoned that an impairment in AtUTr1 expression should perturb the calnexin/calreticulin cycle leading to an increase in misfolded protein and triggering the UPR. Toward that end, we analyzed an AtUTr1 insertional mutant and found an up-regulation of the ER chaperones BiP and calnexin, suggesting that these plants may be constitutively activating the UPR. Thus, we propose that in A. thaliana, AtUTr1 is the UDP-glucose transporter involved in quality control in the ER.https://www.jbc.org/article/S0021-9258(19)56445-6/fulltex

Comparación de la percepción social en playas recreativas arenosas de dos bahías localizadas en el Pacífico Mexicano

En el presente trabajo se desarrollaron dos formatos de encuesta, para incorporar la percepción de los usuarios a la evaluación de la calidad de las playas (Cervantes, 2006 y Silva-Iñiguez, 2006); ambos basados en un modelo cuantitativo para revelar la percepción social de las playas localizadas en la bahía de Santiago, Manzanillo, Col (MZO) y en Acapulco, Gro (ACA). Se aplicaron un total de 790 encuestas (ACA: 390 y MZO: 400), que permitieron conocer el perfil de los usuarios, sus hábitos de recreación y sus opiniones sobre las condiciones biofísicas y de infraestructura de cada playa. En ambas playas la mayoría prefirieron asistir acompañados por sus familias; las principales actividades recreativas fueron nadar, descansar, comer y beber. En general las demandas en ambos sitios coincidieron con incrementar el número de botes de basura, la frecuencia en el servicio de recolección y limpieza, baños y regaderas. Las razones por la que los usuarios seleccionaron la playa a visitar fueron la seguridad y vigilancia, así como las características biofísicas de la misma. La incorporación de esta información a modelos y/o esquemas de evaluación y gestión de playa (a través de índices ambientales) permitió realizar la valoración integral de la playa.In this paper it was developed two survey formats, to include the perception of users on the assessment of the quality of the beaches (Cervantes, 2006 and Silva-Iñiguez, 2006), both based on a quantitative model to reveal the social perception of the beaches on Santiago Bay, Manzanillo, Col (MZO) and Acapulco, Guerrero (ACA). We did a total of 790 surveys (ACA: 390 and MZO: 400), which allowed the user profile, recreation habits and their views on the biophysical and infrastructure of each beach. In both beaches, most people, attended with their families, the main recreational activities were swimming, resting, eating and drinking. In general the demands on both sites agreed to increase the number of waste baskets, the frequency of collection service and cleaning bathrooms and showers. The reasons why the users selected to visit the beach were the safety and security, as well as the biophysical characteristics of the same. Incorporating this information to models and / or evaluation schemes and beach management (through environmental ratings) allowed the comprehensive assessment of the beach

Current concepts: tissue engineering and regenerative medicine applications in the ankle joint

Tissue engineering and regenerative medicine (TERM) has caused a revolution in present and future trends of medicine and surgery. In different tissues, advanced TERM approaches bring new therapeutic possibilities in either general population as in young patients and high-level athletes, improving restoration of biological functions and rehabilitation. The mainstream components required to obtain a functional regeneration of tissues may include biodegradable scaffolds, drugs or growth factors and different cell types (either autologous or heterologous) that can be cultured in bioreactor systems (in vitro) prior implantation into the patient. Particularly in the ankle, that is subject of many different injuries (e.g. acute, chronic, traumatic, degenerative), there is still no definitive and feasible answer to “conventional” methods. This review aims to provide current concepts of TERM applications to ankle injuries under pre-clinical and/or clinical research applied to skin, tendon, bone and cartilage problems. A particular attention has been given to biomaterials design and scaffolds processing with potential use in osteochondral ankle lesions.The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) through the POCTI and FEDER programmes, including Project OsteoCart (grant no. PTDC/CTM-BPC/115977/2009) for providing funds

Null Models of Economic Networks: The Case of the World Trade Web

In all empirical-network studies, the observed properties of economic networks are informative only if compared with a well-defined null model that can quantitatively predict the behavior of such properties in constrained graphs. However, predictions of the available null-model methods can be derived analytically only under assumptions (e.g., sparseness of the network) that are unrealistic for most economic networks like the World Trade Web (WTW). In this paper we study the evolution of the WTW using a recently-proposed family of null network models. The method allows to analytically obtain the expected value of any network statistic across the ensemble of networks that preserve on average some local properties, and are otherwise fully random. We compare expected and observed properties of the WTW in the period 1950-2000, when either the expected number of trade partners or total country trade is kept fixed and equal to observed quantities. We show that, in the binary WTW, node-degree sequences are sufficient to explain higher-order network properties such as disassortativity and clustering-degree correlation, especially in the last part of the sample. Conversely, in the weighted WTW, the observed sequence of total country imports and exports are not sufficient to predict higher-order patterns of the WTW. We discuss some important implications of these findings for international-trade models.Comment: 39 pages, 46 figures, 2 table

Alert classification for the ALeRCE broker system: The real-time stamp classifier

We present a real-time stamp classifier of astronomical events for the Automatic Learning for the Rapid Classification of Events broker, ALeRCE. The classifier is based on a convolutional neural network, trained on alerts ingested from the Zwicky Transient Facility (ZTF). Using only the science, reference, and difference images of the first detection as inputs, along with the metadata of the alert as features, the classifier is able to correctly classify alerts from active galactic nuclei, supernovae (SNe), variable stars, asteroids, and bogus classes, with high accuracy (~94%) in a balanced test set. In order to find and analyze SN candidates selected by our classifier from the ZTF alert stream, we designed and deployed a visualization tool called SN Hunter, where relevant information about each possible SN is displayed for the experts to choose among candidates to report to the Transient Name Server database. From 2019 June 26 to 2021 February 28, we have reported 6846 SN candidates to date (11.8 candidates per day on average), of which 971 have been confirmed spectroscopically. Our ability to report objects using only a single detection means that 70% of the reported SNe occurred within one day after the first detection. ALeRCE has only reported candidates not otherwise detected or selected by other groups, therefore adding new early transients to the bulk of objects available for early follow-up. Our work represents an important milestone toward rapid alert classifications with the next generation of large etendue telescopes, such as the Vera C. Rubin Observatory.The authors acknowledge support from the National Agency of Research and Development’s Millennium Science Initiative through grant IC12009, awarded to the Millennium Institute of Astrophysics (RC, ER, CV, FF, PE, GP, FEB, IR, PSS, GC, SE, Ja, EC, DR, DRM, MC) and from the National Agency for Research and Development (ANID) grants: BASAL Center of Mathematical Modelling AFB-170001 (CV, FF, IR, ECN, CS, ECI) and Centro de Astrofísica y Tecnologías Afines AFB170002 (FEB, PSS, MC); FONDECYT Regular #1171678 (PE), #1200710 (FF), #1190818(FEB), #1200495 (FEB), #1171273 (MC), #1201793(GP); FONDECYT Postdoctorado #3200250 (PSS); FONDECYT Iniciación #11191130 (CV); Magíster Nacional 2019 #22190947 (ER). This work was funded in part by project CORFO 10CEII-9157 Inria Chile (PS). The authors acknowledge financial support from the Spanish Ministry of Science, Innovation, and Universities (MICIU) under the 2019 Ramón y Cajal program RYC2019- 027683 (LG)