Estrategias para la implementación de la facturación electrónica para las mipymes en Cúcuta, Colombia

El propósito de la investigación fue elaborar estrategias para la implementación de la facturación electrónica, donde el objeto de estudio fueron las mipymes de los sectores servicio y comercio en la ciudad Cúcuta. Se aplicó como instrumento de recolección de información, la encuesta de transformación digital del Ministerio de Tecnologías de la Información y las Comunicaciones adaptada por el Centro de Transformación Digital de la Cámara de Comercio de Cúcuta, con la finalidad de conocer el estado de avance de las empresas en transformación digital e implementación de la facturación electrónica. Dentro de los hallazgos obtenidos se determinó que el 25% de las mipymes de la región cuenta actualmente con la factura electrónica, el 50% se encuentra en fase de implementación mientras que el 25% no ha iniciado el proceso. De las mipymes analizadas se determinó que el 62% están dispuestas a destinar entre el 2% y el 4% de sus ingresos para promover procesos de inversión en tecnología digital para el fortalecimiento competitivo. Se establecieron líneas de acción enfocadas a la implementación de la facturación electrónica para las mipymes del sector terciario de la economía regional, la asignación e inversión de recursos financieros para mejorar las competencias en el personal para adaptarse y absorber las tecnologías UNIVERSIDAD LIBRE SECCIONAL CÚCUTA CENTRO SECCIONAL DE INVESTIGACIONES FORMATO INSTITUCIONAL PROPUESTA DE INVESTIGACIÓN / PRESENTACIÓN DE TEMÁTICA EN LOS PROGRAMAS DE PREGRADO Y POSGRADO Facultad de Derecho, Ciencia Política y Sociales, Ingenierías & Ciencias Económicas, Administrativas y Contables, digitales, sumado a la planeación, ejecución y control de los procesos de transformación digital en la gestión administrativa y financiera del modelo de negocio

Técnicas de citología de impresión conjuntival empleadas para el diagnóstico de patologías del segmento anterior: revisión sistemática de literatura

Objetivo: Describir los avances de la citología de impresión conjuntival empleada para el análisis morfológico y morfométrico de patologías del segmento anterior, según lo reportado en la literatura en los últimos años, para evidenciar las ventajas de la técnica como prueba diagnóstica confirmatoria. Pregunta PICO: ¿Cuáles son las técnicas de citología de impresión conjuntival empleadas para determinar la presencia de metaplasias y neoplasias conjuntivales que permiten confirmar el diagnóstico de patologías del segmento anterior y la película lagrimal? Metodología: La presente revisión empleó elementos metodológicos propios de la revisión sistemática de literatura. Se consultó en plataformas académicas tales como: Google académico, Scielo, Springer Link, Science Direct, Elsevier, Medline. Así mismo, se acudió a expertos en el tema y a la búsqueda en cadena para rastrear publicaciones y así dar respuesta a la pregunta de investigación. Resultados: Las técnicas de tinción más reportadas para el análisis del tejido conjuntival bulbar fueron: el ácido peryódico de Schiff (PAS) y hematoxilina-eosina. Así mismo, las muestras en su mayoría fueron tomadas con el filtro de acetato de celulosa y los hallazgos se interpretaron según la clasificación de Nelson. Conclusión: La citología de impresión conjuntival (CIC) es una técnica de fácil empleo y eficaz que permite identificar patologías importantes que afectan la superficie ocular como la enfermedad de ojo seco (EOS) y permite evidenciar los cambios en el epitelio ocular dados por enfermedades sistémicas.Objective: To describe the advances in conjunctival impression cytology used for the morphological and morphometric analysis of pathologies of the anterior segment, as reported in the literature in recent years. In order to teach visual health professionals, the advantages of the conjunctival impression technique and, in turn, how it can help an accurate diagnosis in clinical practice. PICO question: What are the conjunctival impression cytology techniques used to determine the presence of conjunctival metaplasias and neoplasms to confirm the diagnosis of anterior segment and tear film pathologies? Methodology: This review used methodological elements typical of the systematic review of literature. It was consulted on academic platforms such as: Google academic, Scielo, Springer Link, Science Direct, Elsevier, Medline. Likewise, experts on the subject and a chain search were used to track publications and thus answer the question. Results: The most reported staining techniques for the analysis of bulbar conjunctival tissue were periodic acid Schiff (PAS) and hematoxylin-eosin, since they were mentioned in 11 publications. Likewise, it is highlighted that the conjunctival samples were taken in most cases using the cellulose acetate filter and the findings were interpreted according to Nelson's classification. Conclusion: The conjunctival impression cytology (CIC) is an easy-to-use and effective technique that should be considered as a diagnostic support test since it allows the identification of important pathologies that affect the ocular surface, such as eye disease. In the same way, the CIC allows to demonstrate the changes in the ocular epithelium given by systemic diseases

Retos, avances y reflexiones transdisciplinares desde contextos educativos diversos

La publicación de las ponencias que conformaron el V Congreso Internacional de Educación de la Universidad Nacional de Educación, titulado Retos, avances y reflexiones transdisciplinares desde contextos educativos diversos, ofrece una visión comprensiva y multifacética de la educación contemporánea. A través de ocho ejes temáticos, entre los que se incluye la formación integral y el desarrollo profesional, la teoría y la práctica en la formación profesional docente, la relación entre sociedad y escuela, la gestión educativa y las tecnologías para la educación, esta recopilación busca contribuir al conocimiento académico sobre la educación y, al mismo tiempo, ser fuente de información e inspiración para educadores, investigadores y todas aquellas personas interesadas en el desarrollo educativo

Sistema de Medición de Nivel de Combustible en Autos “Mini Baja”

En este trabajo se presenta la propuesta-proyecto de un sistema de “medición” visual de combustible para vehículos de la rama “baja” por la Sociedad de Ingenieros Automotrices (sae, por sus siglas en inglés). Se realizó el proceso con la ayuda de la plataforma de electrónica abierta Arduino. Su funcionamiento fue logrado en conjunto con un sensor de presión diferencial producido por la compañía Freescale. La elaboración de este sistema tiene como objetivo que el piloto verifique de manera visual el nivel de combustible en todo momento y con ello optimizar el tiempo durante las competencias “Mini Baja sae”, a las cuales asiste el vehículo de la Universidad Autónoma de Ciudad Juárez (uacJ) desde el año 2007. La competencia “Mini Baja sae” es organizada anualmente por la sociedad de ingenieros automotrices. Dicha competencia ha logrado desarrollarse a tal grado que en la actualidad se considera un pilar en el fortalecimiento del conocimiento en el diseño automotriz

Size and Shape Constraints of (486958) Arrokoth from Stellar Occultations

International audienceWe present the results from four stellar occultations by (486958) Arrokoth, the flyby target of the New Horizons extended mission. Three of the four efforts led to positive detections of the body, and all constrained the presence of rings and other debris, finding none. Twenty-five mobile stations were deployed for 2017 June 3 and augmented by fixed telescopes. There were no positive detections from this effort. The event on 2017 July 10 was observed by the Stratospheric Observatory for Infrared Astronomy with one very short chord. Twenty-four deployed stations on 2017 July 17 resulted in five chords that clearly showed a complicated shape consistent with a contact binary with rough dimensions of 20 by 30 km for the overall outline. A visible albedo of 10% was derived from these data. Twenty-two systems were deployed for the fourth event on 2018 August 4 and resulted in two chords. The combination of the occultation data and the flyby results provides a significant refinement of the rotation period, now estimated to be 15.9380 ± 0.0005 hr. The occultation data also provided high-precision astrometric constraints on the position of the object that were crucial for supporting the navigation for the New Horizons flyby. This work demonstrates an effective method for obtaining detailed size and shape information and probing for rings and dust on distant Kuiper Belt objects as well as being an important source of positional data that can aid in spacecraft navigation that is particularly useful for small and distant bodies

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability: Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)