Remote Sensing and Control of Phase Qubits

We demonstrate a remote sensing design of phase qubits by separating the control and readout circuits from the qubit loop. This design improves measurement reliability because the control readout chip can be fabricated using more robust materials and can be reused to test different qubit chips. Typical qubit measurements such as Rabi oscillations, spectroscopy, and excited-state energy relaxation are presented.Comment: 3 pages, 4 figure

Delayed epistaxis secondary to intracavernous pseudoaneurysm of internal carotid artery

Post-traumatic pseudoaneurysm of the internal carotid artery is a very rare but potentially fatal cause of epistaxis. Early diagnosis is essential for an adequate management of this entity. The authors present a case of pseudoaneurysm of the internal carotid artery that developed massive epistaxis six months after skull base trauma.Pseudoaneurisma traumático da artéria carótida interna é uma causa rara de epistaxe, porém potencialmente fatal. O diagnóstico precoce é essencial para um adequado manejo da patologia. Os autores relatam um caso de pseudoaneurisma da carótida interna que se apresentou como epistaxe maciça após seis meses de trauma craniano prévio.Hospital do Servidor Público do Estado de São Paulo Serviço de Otorrinolaringologia/Cabeça e PescoçoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciEL

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

: Microparticulate systems such as microparticles, microspheres, microcapsules or any particle in a micrometer scale (usually of 1-1000 µm) are widely used as drug delivery systems, because they offer higher therapeutic and diagnostic performance compared to conventional drug delivery forms. These systems can be manufactured with many raw materials, especially polymers, most of which have been effective in improving the physicochemical properties and biological activities of active compounds. This review will focus on the in vivo and in vitro application in the last decade (2012 to 2022) of different active pharmaceutical ingredients microencapsulated in polymeric or lipid matrices, the main formulation factors (excipients and techniques) and mostly their biological activities, with the aim of introducing and discussing the potential applicability of microparticulate systems in the pharmaceutical field

Precipitation influence on the runoff of a small-watershed in the Federal District, Brazil

O conhecimento do escoamento superficial é importante para o dimensionamento de obras hidráulicas e para a conservação da água e do solo. O volume de água escoado superficialmente depende de fatores de natureza edafoclimática e fisiográfica da região. O objetivo deste estudo foi verificar a influência relativa do total precipitado (P), da precipitação antecedente (PA) e da intensidade de precipitação (IP) na ocorrência de eventos de escoamento superficial (Es), na microbacia do Córrego Capetinga, situada no Centro-Oeste do Brasil, região de cerrado. Foram analisados os dados de P, PA e IP obtidos durante seis anos hidrológicos, iniciando em 1º de julho de 1996 e terminando em 30 de junho 2002. Foram somente considerados valores de Es maiores ou iguais a 0,1 mm, oriundos de hidrógrafas geradas a partir dos dados de linígrafo instalado na saída da bacia. Um conjunto de 187 dados de P, PA, IP e Es foram submetidos à análise de regressão linear múltipla. Os resultados mostraram que as variáveis independentes P, PA e IP têm dupla e tríplice interação, influenciando na variável dependente Es. Por intermédio dos valores absolutos dos coeficientes de regressão, constatou-se que IP foi mais importante do que PA na estimativa da variável Es. O valor do coeficiente de escoamento superficial total médio sugere que a microbacia possui boas condições de infiltração de água no solo.The knowledge of surface runoff is important for adequate hydraulic structures designing and for soil water conservation. The total volume of water from surface runoff is dependent of local edaphic, climatic and physiographic conditions. The objective of this study was to find out the relative importance of rainfall amount (P) and intensity (IP) and antecedent precipitation (PA) on total runoff (Es) provided by the "Capetinga" stream watershed, located in Brazil mid-west savannah region. It was analyzed watershed data for a six years period beginning on July 1st, 1996, and ending on June 30th, 2002. It was considered only Es events greater or equal to 0.1 mm, measured with a stream gage located at the watershed outlet. A set of 187 P, PA, IP and Es events were submitted to a linear multiple regression analysis. The results showed that the independent variable P, PA and IP had two and three-factor interactions, influencing the dependent variable Es. Regression coefficients of absolute values evidenced that IP was more important than PA to estimate de independent variable Es. The average total runoff coefficient value suggests that the watershed has a good condition of soil water infiltration

Estolides Synthesis Catalyzed by Immobilized Lipases

Estolides are vegetable-oil-based lubricants obtained from oleic acid or any source of hydroxy fatty acids. In this work, the estolides synthesis from oleic acid and methyl ricinoleate (biodiesel from castor oil), using immobilized commercial lipases (Novozym 435, Lipozyme RM-IM, and Lipozyme TL-IM) in a solvent-free medium was investigated. Acid value was used to monitor the reaction progress by determining the consumption of acid present in the medium. Novozym 435 showed the best performance. Water removal improved the conversion. Novozym 435 was more active at atmospheric pressure. Novozym 435 was reused four times with conversion reaching 15% after the fourth reaction at 80°C. Estolides produced under the reaction conditions used in this work presented good properties, such as, low temperature properties as pour point (−24°C), viscosity (23.9 cSt at 40°C and 5.2 cSt at 100°C), and viscosity index (153)

Sub-micrometer epitaxial Josephson junctions for quantum circuits

We present a fabrication scheme and testing results for epitaxial sub-micrometer Josephson junctions. The junctions are made using a high-temperature (1170 K) "via process" yielding junctions as small as 0.8 mu m in diameter by use of optical lithography. Sapphire (Al2O3) tunnel-barriers are grown on an epitaxial Re/Ti multilayer base-electrode. We have fabricated devices with both Re and Al top electrodes. While room-temperature (295 K) resistance versus area data are favorable for both types of top electrodes, the low-temperature (50 mK) data show that junctions with the Al top electrode have a much higher subgap resistance. The microwave loss properties of the junctions have been measured by use of superconducting Josephson junction qubits. The results show that high subgap resistance correlates to improved qubit performance

Subglottic stenosis as a clinical manifestation of Wegener's granulomatosis in adolescents: report of a case and review of literature

Wegener's Granulomatosis is a well-characterized systemic vasculitis and necrotising granulomatous inflammation of the upper, lower respiratory tracts and the kidneys. The initial manifestations of the disease usually occur in patients over than twenty years old. The otolaryngologic symptoms like rhinorrhea, recurrent sinusitis and epistaxis are commonly present in early course of the disease. It seems that subglottic stenosis is correlated to Wegener's granumatosis in adolescents. We describe a case of a patient that developed subglottic stenosis associated with Wegener's granulomatosis in childhood during the course of the disease.A Granulomatose de Wegener é uma patologia caracterizada por vasculite sistêmica e inflamação granulomatosa necrotizante que compromete o trato respiratório alto, pulmões e rins, cujas manifestações iniciais, na maioria das vezes, ocorre em maiores de 20 anos de idade. As queixas clínicas otorrinolaringológicas estão, com freqüência, presentes nas fases iniciais da doença, sendo rinite, sinusopatia de repetição e epistaxe as mais comuns. A estenose subglógica parece estar correlacionada com a Granulomatose de Wegener em adolescentes. Relatamos o caso de uma paciente portadora de Granulomatose de Wegener cujo início dos sintomas foi na infância, tendo evoluído com estenose laríngea durante o curso da doença.Hospital do Servidor Público do Estado de São Paulo Serviço de Otorrinolaringologia/Cabeça e PescoçoFaculdade de Medicina de São Paulo Divisão de Clínica OtorrinolaringológicaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciEL

Dietary l-tryptophan leaves a lasting impression on the brain and the stress response

publishedVersionNivå

A linguagem literária do New Journalism em The Duke in His Domain

O presente artigo possui o intuito de esclarecer como a linguagem literária foi atrelada à linguagem jornalística na categoria New Journalism (Novo Jornalismo, no português). Para isso, utilizamos trechos do artigo The Duke in His Domain, de Truman Capote, que se trata de um perfil-reportagem do ator hollywoodiano Marlon Brando, escrito em 1957 e publicado na famosa revista nova-iorquina, The New Yorker. A relevância para análise deste objeto de pesquisa não é somente em relação ao toque literário, mas também devido a sua importância histórica e jornalística, pois é sabido que tal texto é um precursor do New Journalism. O referencial teórico da pesquisa é embasado em um artigo de Cyntia Belgini Andretta, estudiosa da obra de Truman Capote, e em autores que se dedicam ao estudo do jornalismo-literário, como Eduardo Belo e Marcelo Bulhões. Com o resultado da pesquisa, a análise de trechos do artigo de Capote ajudará a esclarecer dúvidas em relação ao uso dos recursos literários dentro do jornalismo