Electron Drift Velocities In N2, CO2, And (N 2+CO2) Laser Mixtures

A time-of-flight technique has been used to obtain electron drift velocities in N2, CO2, and N2-CO2 mixtures covering the E/N range 3-93 Td. In the case of the pure gases, excellent agreement with previous work is obtained over the entire E/N range. The mixtures, which are of laser importance, have not been studied previously

Spin-polarized electron transmission in dna-like systems

The helical distribution of the electronic density in chiral molecules, such as DNA and bacteriorhodopsin, has been suggested to induce a spin-orbit coupling interaction that may lead to the so-called chirality-induced spin selectivity (CISS) effect. Key ingredients for the theoretical modelling are, in this context, the helically shaped potential of the molecule and, concomitantly, a Rashba-like spin-orbit coupling due to the appearance of a magnetic field in the electron reference frame. Symmetries of these models clearly play a crucial role in explaining the observed effect, but a thorough analysis has been largely ignored in the literature. In this work, we present a study of these symmetries and how they can be exploited to enhance chiral-induced spin selectivity in helical molecular systems

Estimation of the road dust contribution in the urban aerosol

The urban area of Madrid (Spain), as in many other cities worldwide, is characterized by poor ambient air quality. Previous studies in the area have pointed out traffic as the main source of fine particles, while dust resuspension was found to be responsible for elevated levels of coarse particles (Querol et al, 2004). Street washing is one of the methods that might reduce the dust resuspension. The aim of this study was to quantify the contribution of road dust to particulate matter and evaluate the effects of street washing on the strength of resuspensio

Suppression of metastatic organ colonization and antiangiogenic activity of the orally bioavailable lipid raft-targeted alkylphospholipid edelfosine

Metastasis is the leading cause of cancer mortality. Metastatic cancer is notoriously difficult to treat, and it accounts for the majority of cancer -related deaths. The ether lipid edelfosine is the prototype of a family of synthetic antitumor compounds collectively known as alkylphospholipid analogs, and its antitumor activity involves lipid raft reorganization. In this study, we examined the effect of edelfosine on metastatic colonization and angiogenesis. Using non-invasive bioluminescence imaging and histological examination, we found that oral administration of edelfosine in nude mice significantly inhibited the lung and brain colonization of luciferaseexpressing 435-Lung-eGFP-CMV/Luc metastatic cells, resulting in prolonged survival. In metastatic 435 -Lung and MDA-MB-231 breast cancer cells, we found that edelfosine also inhibited cell adhesion to collagen -I and laminin-I substrates, cell migration in chemotaxis and wound -healing assays, as well as cancer cell invasion. In 435 -Lung and other MDA-MB-435-derived sublines with different organotropism, edelfosine induced G2/M cell cycle accumulation and apoptosis in a concentration- and time -dependent manner. Edelfosine also inhibited in vitro angiogenesis in human and mouse endothelial cell tube formation assays. The antimetastatic properties were specific to cancer cells, as edelfosine had no effects on viability in non -cancerous cells. Edelfosine accumulated in membrane rafts and endoplasmic reticulum of cancer cells, and membrane raft -located CD44 was downregulated upon drug treatment. Taken together, this study highlights the potential of edelfosine as an attractive drug to prevent metastatic growth and organ colonization in cancer therapy. The raft -targeted drug edelfosine displays a potent activity against metastatic organ colonization and angiogenesis, two major hallmarks of tumor malignancy

Reconocimiento de la tradici?n constructiva y la cultura habitacional de la comunidad ind?gena Mesa de Cucuana Aceituno en Ortega Tolima

348 p. Recurso Electr?nicoEste proyecto de grado busca reconocer la tradici?n constructiva y la cultura habitacional de la comunidad ind?gena Mesa de Cucuana Aceituno, en el Municipio de Ortega, Departamento del Tolima; para preservar las din?micas socio-espaciales de la poblaci?n del cabildo, que a trav?s de los a?os han venido desapareciendo a ra?z de diferentes factores. Con la finalidad de ofrecerles a los habitantes de la comunidad ind?gena una alternativa de vivienda acorde a sus modos de vida y din?micas espaciales tradicionales; y as? ayudar a subsanar el d?ficit tanto cualitativo como cuantitativo presente actualmente en la comunidad, se plantea el reconocimiento de la habitabilidad mediante la investigaci?n meticulosa para desarrollar una propuesta coherente con lo descrito anteriormente. De esta manera, el trabajo se desarrolla en tres etapas: Reconocimiento de las t?cnicas tradicionales, procesos y materialidad en la construcci?n de viviendas propias del territorio ind?gena de Mesa de Cucuana Aceituno. Seguidamente, el estudio y an?lisis de los modos de vida, costumbres y tradiciones de la habitabilidad de la poblaci?n con respecto a sus viviendas y el entorno donde se encuentran emplazadas. Finalmente, a partir de todo el reconocimiento desarrollado, plantear el dise?o arquitect?nico y urban?stico de una propuesta de agrupaci?n de viviendas junto con tres modelos de vivienda ind?gena acordes con sus costumbres y tradiciones, respetando su cultura habitacional y las condiciones de su entorno; por ?ltimo, proyectar un esquema b?sico del dise?o de un equipamiento social y sede del Cabildo Mesa de Cucuana Aceituno, como espacio complementario a la vivienda.This degree seeks to recognize the traditional construction and residential culture of the indigenous community Mesa of Cucuana Aceituno, in the municipality of Ortega, Department of Tolima; to preserve the socio-spatial dynamics of the population of the Town Hall, that through the years have been disappearing as a result of various factors. With the purpose of offer you to the inhabitants of the community indigenous an alternative of housing according to their modes of life and dynamic space traditional; and thus help to remedy the deficit both qualitative as quantitative present currently in the community. In this way, the work develops in three stages: recognition of traditional techniques, processes and material in the construction of houses of the indigenous territory of Mesa of Cucuana Aceituno. Then, the study and analysis of the ways of life, customs and traditions of the habitability of the population with regard to their homes and the environment where they are placed. Finally, through the design architectural and urban project three models of housing indigenous chords with their customs and traditions, a proposed of grouping of housing, respecting its culture housing and the conditions of its environment, and, finally, a scheme basic of the design of an equipment social and headquarters of the Cabildo Mesa of Cucuana Aceituno, as space complementary to it housing. Key words: Indigenous housing, liveability, constructive traditio

Patient-reported outcomes of periacetabular osteotomy from the prospective ANCHOR cohort study

BACKGROUND: Current literature describing the periacetabular osteotomy (PAO) is mostly limited to retrospective case series. Larger, prospective cohort studies are needed to provide better clinical evidence regarding this procedure. The goals of the current study were to (1) report minimum 2-year patient-reported outcomes (pain, hip function, activity, overall health, and quality of life), (2) investigate preoperative clinical and disease characteristics as predictors of clinical outcomes, and (3) report the rate of early failures and reoperations in patients undergoing contemporary PAO surgery. METHODS: A large, prospective, multicenter cohort of PAO procedures was established, and outcomes at a minimum of 2 years were analyzed. A total of 391 hips were included for analysis (79% of the patients were female, and the average patient age was 25.4 years). Patient-reported outcomes, conversion to total hip replacement, reoperations, and major complications were documented. Variables with a p value of ≤0.10 in the univariate linear regressions were included in the multivariate linear regression. The backward stepwise selection method was used to determine the final risk factors of clinical outcomes. RESULTS: Clinical outcome analysis demonstrated major clinically important improvements in pain, function, quality of life, overall health, and activity level. Increasing age and a body mass index status of overweight or obese were predictive of improved results for certain outcome metrics. Male sex and mild acetabular dysplasia were predictive of lesser improvements in certain outcome measures. Three (0.8%) of the hips underwent early conversion to total hip arthroplasty, 12 (3%) required reoperation, and 26 (7%) experienced a major complication. CONCLUSIONS: This large, prospective cohort study demonstrated the clinical success of contemporary PAO surgery for the treatment of symptomatic acetabular dysplasia. Patient and disease characteristics demonstrated predictive value that should be considered in surgical decision-making. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence

Automatic evaluation of the adherence to recommendations for managing heart failure from the electronic health records : The EXEMED tool

Objetivo La implementación de las guías de práctica clínica está limitada por la falta de herramientas que faciliten los procesos de auditoría y retroalimentación a los profesionales de salud. Este estudio evalúa la herramienta automatizada (EXEMED), diseñada para valorar la adherencia a las guías de práctica clínica a partir de la información consignada en las historias clínicas electrónicas. Métodos En un grupo de 35 pacientes hospitalizados entre enero y marzo de 2016 se evaluó la adherencia a cinco recomendaciones contenidas en las guías de práctica clínica de falla cardiaca del Hospital Universitario San Ignacio. Se utilizó la herramienta automatizada EXEMED y se evaluó la validez de la misma comparando los resultados con la valoración realizada por una junta médica independiente. Se determinó concordancia entre los dos métodos usando el coeficiente kappa. Resultados La adherencia a las diferentes recomendaciones osciló entre 0% para la determinación del perímetro abdominal al ingreso, hasta 97% para el uso de betabloqueadores al egreso. La proporción de acuerdo entre los dos métodos de evaluación estuvo por encima del 90% para todas las recomendaciones. El kappa para las diferentes recomendaciones fue de 0,78 (IC 95% 0,62-0,95) y 0,64 (0,48-0,80). El tiempo de evaluación se redujo de veinte a dos minutos por paciente con el uso de la herramienta EXEMED. Conclusiones EXEMED es una herramienta válida y eficiente en la evaluación de la adherencia a las guías de práctica clínica. Se requieren nuevos estudios para evaluar el impacto de su uso asociado a retroalimentación a los clínicos, en la evolución a largo plazo de los pacientes con falla cardiaca.Q4Artículo original321-326Objective The implementation of clinical practice guidelines is limited due to the lack of tools to carry out audits and provide feedback to the health professionals. In this study, an evaluation is performed using the automated (EXEMED) tool in order to assess the adherence to clinical practice guidelines from the information entered in the electronic health records. Methods The adherence to 5 recommendations contained in the heart failure clinical practice guidelines was evaluated in a group of 35 patients admitted to the Hospital Universitario San Ignacio between January 2016 and March 2016. The automated EXEMED tool was used to assess this, by comparing the results obtained with the evaluation carried out by an independent medical committee. The kappa coefficient was used to determine the agreement between the two methods. Results The adherence to the different recommendations varied between 0%, for the determination of the abdominal circumference, up to 97%, for the use of beta-blockers at discharge. Percentage agreement between the two evaluation methods was above 90% for all the recommendations. The kappa for the different recommendations was 0.78 (95% CI; 0.62-0.95) and 0.64 (0.48-0.80). The evaluation time was reduced from 20minutes to 2minutes with the use of the EXEMED tool. Conclusions EXEMED is a valid and effective tool in the evaluation of adherence to clinical practice guidelines. Further studies are required to assess the impact of its used associated with feedback to the clinicians, in the long-term outcomes of patients with heart failure