Patellofemoral Tracking Resulting From Decreased Activation Of The Vastus Medialis Muscle

Patellofemoral pain is one of the most frequent knee conditions seen by sports medicine providers. Dysfunctional tracking of the patella is thought to be a cause. The purpose of this project was to determine if reduced maximal strength of the vastus medialis would cause muscle forces in a model to increase laterally directed patellar forces or torsion. 2 participants completed 5 maximum effort jumps and landings. Models were made in Matlab to calculate torques required to produce the given motion. The model was altered to reduce the force producing capability of the vastus medialis. The patellar tendon force was calculated for decreased amounts of normal force producing capabilities. Paired T-tests were utilized. The reduced maximum force producing capabilities of the vastus medialis decreased its estimated muscle force and increased the vastus lateralis muscle force in order to create enough torque to produce the movement. Peak patellar mediolateral forces were decreased by 0.5% from the 100% condition to the 50% condition while peak patellar torsion was decreased by 4.9%. The expected effects of decreased vastus medialis strength were produced by the models. This resulted in small decreases in laterally direct patellar forces and somewhat larger decreases in patellar torsions

Photography and Folk Art at the Art Institute of Chicago: new models for exhibitions and scholarship

In the 1930s, a surging interest in early American vernacular arts, collectively referred to as folk art, converged with major photographic documentation projects of the Great Depression. These twin impulses—to collect the past and record the present—flourished concurrently during this critical period in American history. As artists, curators, collectors, and even government administrators sought to define American visual identities that were distinct from Europe, they found symbols of an American culture that was egalitarian, unpretentious, and self-made. The exhibition Photography and Folk Art: Looking for America in the 1930s (The Art Institute of Chicago, 2019) brought documentary photographs and folk art objects together to explore the aesthetic and conceptual connections between two fields—linked by overlapping networks of cultural agents—that had long been studied separately in disciplinary silos. This article details the exhibition’s collaborative research and discovery process, innovative display and interpretive strategies, and ultimately present-day relevance for twenty-first century audiences

Re-contacting Cancer Genetic Counseling Patients: Expectations of Patients and Physicians

The landscape of cancer genetic counseling and testing is rapidly evolving. Genetic testing technology is improving, management guidelines are evolving, and genetic testing options are expanding. These frequent updates to the components of cancer genetics have increased the complexity of managing patient care over time. In particular, this raises questions on the duty to re-contact patients as new information becomes available. This study explored healthcare providers’ duty to re-contact through the interests and expectations of patients, including which circumstances warrant re-contacting, which healthcare provider is responsible for re-contacting the patient, and the preferred method of re-contacting. Physicians’ opinions on whether or not patients should be updated as well as the person responsible for updating were also explored. To answer the questions set forth in this study, we surveyed patients undergoing genetic counseling for a hereditary cancer condition and physicians who work with cancer genetic counselors. The study was limited by low response rate from patients, so no statistically significant results could be confirmed. However, both groups indicated re-contacting patients with updates was desirable and assigned a high level of responsibility to providers for delivering these updates to patients. The majority of patient participants believed the duty to keep patients informed fell primarily on the genetic counselor and preferred the genetic counselor to initiate contact. In contrast, physician participants indicated genetic counselors, referring physician, and a shared responsibility between these two providers most frequently as the responsible parties

Average seasonal changes in chlorophyll a in Icelandic waters

The standard algorithms used to derive sea surface chlorophyll a concentration from remotely sensed ocean colour data are based almost entirely on the measurements of surface water samples collected in open sea (case 1) waters which cover ~60% of the worlds oceans, where strong correlations between reflectance and chlorophyll concentration have been found. However, satellite chlorophyll data for waters outside the defined case 1 areas, but derived using standard calibrations, are frequently used without reference to local in situ measurements and despite well-known factors likely to lead to inaccuracy. In Icelandic waters, multiannual averages of 8-d composites of SeaWiFS chlorophyll concentration accounted for just 20% of the variance in a multiannual dataset of in situ chlorophyll a measurements. Nevertheless, applying penalized regression spline methodology to model the spatial and temporal patterns of in situ measurements, using satellite chlorophyll as one of the predictor variables, improved the correlation considerably. Day number, representing seasonal variation, accounted for substantial deviation between SeaWiFS and in situ estimates of surface chlorophyll. The final model, using bottom depth and bearing to the sampling location as well as the two variables mentioned above, explained 49% of the variance in the fitting dataset

Approaches to interdisciplinary mixed methods research in land change science and environmental management

Combining qualitative and quantitative methods and data is crucial to understanding the complex dynamics and often interdisciplinary nature of conservation. Many conservation scientists use mixed methods, but there are a variety of mixed methods approaches, a lack of shared vocabulary, and few methodological frameworks. We reviewed articles from 2 conservation-related fields that often incorporate qualitative and quantitative methods: land-change science (n= 16) and environmental management (n= 16). We examined how authors of these studies approached mixed-methods research by coding key methodological characteristics, including relationships between method objectives, extent of integration, iterative interactions between methods, and justification for use of mixed methods. Using these characteristics, we created a typology with the goal of improving understanding of how researchers studying land-change science and environmental management approach interdisciplinary mixed methods research. We found 5 types of mixed methods approaches, which we termed simple nested, informed nested, simple parallel, unidirectional synthesis, and bidirectional synthesis. Methods and data sources were often used to address different research questions within a project, and only around half of the reviewed papers methodologically integrated different forms of data. Most authors used one method to inform the other rather than both informing one another. Very few articles used methodological iteration. Each methodological type has certain epistemological implications, such as the disciplinary reach of the research and the capacity for knowledge creation through the exchange of information between distinct methodologies. To exemplify a research design that can lead to multi-dimensional knowledge production, we provide a methodological framework that bidirectionally integrates and iterates qualitative and quantitative methods

The status of local smoking regulations in North Carolina following a state preemption bill

Objective. —To determine the number and protectiveness of local smoking regulations adopted before the implementation of a preemptive statewide smoking control bill. Method. —Review of local smoking control regulations from all 100 counties and 85 municipalities with populations greater than 5000 in North Carolina. Main Outcome Measures. —Adoption of local smoking control regulations before and during the 3-month delay in enactment of the preemptive bill. Protectiveness of regulations was based on restrictions on smoking and requirements for separate ventilation systems at private work sites: none (smoking unrestricted); minimal (smoking restricted to designated areas); partial (smoking restricted to designated areas served by separate ventilation systems); and complete (smoking prohibited). Because some regulations would be phased in gradually over the next 5 years, we evaluated the requirements that will be in effect by January 1, 2000. Results. —Between July 15 and October 15,1993, the number of local smoking regulations in North Carolina increased from 16 to 105. By the year 2000, 59% of private employees still will not be guaranteed any protection from work site environmental tobacco smoke; 19% will have minimal protection, 22% will have partial protection, and none will have complete protection. Conclusions. —The 3-month delay in preemption created an unnatural time frame for communities to organize, debate, and adopt smoking restrictions. Despite the adoption of 89 new regulations, no private employees will be guaranteed complete protection from work site environmental tobacco smoke by the year 2000; new regulations can no longer be adopted. HB 957 has been a setback for public health in North Carolina

Small advances and swift retreat: Race-conscious educational policy in the Obama and Trump administrations

The three terms comprising the Obama and Trump presidencies provide an opportunity to understand the evolution of race-conscious education policy in an increasingly multiracial, unequal, and divided society. Through document review and interviews with civil rights lawyers, government officials, congressional staffers, and intermediary organization personnel, we sought to understand how Obama officials envisioned and changed the role of the federal government in fostering K-12 race-conscious educational policies and what mechanisms they used to advance priorities. We also explored changes Trump administration officials made to federal civil rights policies and through which institutional means. Our findings reveal through-lines between past and present political agendas and the methods for enactment. Obama’s interagency efforts to reinvigorate civil rights oversight and enforcement in education harkened back to the mid-1960s era of bipartisan cooperation around school desegregation. Yet the decades-long legal and policy retrenchment against civil rights advances made in the 1960s constrained further progress. Trump’s administration advocated for the privatization of public education through increased choice and opposed race-consciousness in education law and policy. The reshaping of the federal judiciary under Trump presents challenges for race-consciousness in the law for years to come. Recognizing these consistent through-lines and constraints will be essential for advocates and policymakers going forward

Climatic Drivers for Multi-Decadal Shifts in Solute Transport and Methane Production Zones within a Large Peat Basin

Northern peatlands are an important source for greenhouse gases but their capacity to produce methane remains uncertain under changing climatic conditions. We therefore analyzed a 43-year time series of pore-water chemistry to determine if long-term shifts in precipitation altered the vertical transport of solutes within a large peat basin in northern Minnesota. These data suggest that rates of methane production can be finely tuned to multi-decadal shifts in precipitation that drive the vertical penetration of labile carbon substrates within the Glacial Lake Agassiz Peatlands. Tritium and cation profiles demonstrate that only the upper meter of these peat deposits was flushed by downwardly moving recharge from 1965 through 1983 during a Transitional Dry-to-Moist Period. However, a shift to a moister climate after 1984 drove surface waters much deeper, largely flushing the pore waters of all bogs and fens to depths of 2 m. Labile carbon compounds were transported downward from the rhizosphere to the basal peat at this time producing a substantial enrichment of methane in Delta C-14 with respect to the solid-phase peat from 1991 to 2008. These data indicate that labile carbon substrates can fuel deep production zones of methanogenesis that more than doubled in thickness across this large peat basin after 1984. Moreover, the entire peat profile apparently has the capacity to produce methane from labile carbon substrates depending on climate-driven modes of solute transport. Future changes in precipitation may therefore play a central role in determining the source strength of peatlands in the global methane cycle

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.

A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent transmission and block infection in animal models. But despite the identification of resistance mechanisms in P. falciparum, the mode of action of IZPs remains unknown. To investigate, we here combine in vitro evolution and genome analysis in Saccharomyces cerevisiae with molecular, metabolomic, and chemogenomic methods in P. falciparum. Our findings reveal that IZP-resistant S. cerevisiae clones carry mutations in genes involved in Endoplasmic Reticulum (ER)-based lipid homeostasis and autophagy. In Plasmodium, IZPs inhibit protein trafficking, block the establishment of new permeation pathways, and cause ER expansion. Our data highlight a mechanism for blocking parasite development that is distinct from those of standard compounds used to treat malaria, and demonstrate the potential of IZPs for studying ER-dependent protein processing

Infection by a foliar endophyte elicits novel arabidopside-based plant defence reactions in its host, Cirsium arvense

Endophytic fungi live asymptomatically within plants. They are usually regarded as non-pathogenic or even mutualistic, but whether plants respond antagonistically to their presence remains unclear, particularly in the little-studied associations between endophytes and nong-raminoid herbaceous plants. We investigated the effects of the endophyte Chaetomium cochlioides on leaf chemistry in Cirsium arvense. Plants were sprayed with spores; leaf material from both subsequent new growth and the sprayed leaves was analysed 2 wk later. Infection frequency was 91% and63% for sprayed and new growth, respectively, indicating that C. cochlioides rapidly infects new foliage. Metabolomic analyses revealed marked changes in leaf chemistry with infection, especially in new growth. Changes in several novel oxylipin metabolites were detected, including arabi-dopsides reported here for the first time in a plant species other than Arabidopsis thaliana,and a jasmonate-containing galactolipid. The production of these metabolites in response to endophyte presence, particularly in newly infected foliage, suggests that endophytes elicit similar chemical responses in plants to those usually produced following wounding, herbivory and pathogen invasion. Whether en-dophytes benefit their hosts may depend on a complex series of chemically mediated interactions between the plant, the endophyte, other microbial colonists and natural enemies