Bottom pressure signals at the TAG deep-sea hydrothermal field : evidence for short-period, flow-induced ground deformation

Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 36 (2009): L19301, doi:10.1029/2009GL040006.Bottom pressure measurements acquired from the TAG hydrothermal field on the Mid-Atlantic Ridge (26°N) contain clusters of narrowband spectral peaks centered at periods from 22 to 53.2 minutes. The strongest signal at 53.2 min corresponds to 13 mm of water depth variation. Smaller, but statistically significant, signals were also observed at periods of 22, 26.5, 33.4, and 37.7 min (1–4 mm amplitude). These kinds of signals have not previously been observed in the ocean, and they appear to represent vertical motion of the seafloor in response to hydrothermal flow - similar in many ways to periodic terrestrial geysers. We demonstrate that displacements of 13 mm can be produced by relatively small flow-induced pressures (several kPa) if the source region is less than ∼100 m below the seafloor. We suggest that the periodic nature of the signals results from a non-linear relationship between fluid pore pressure and crustal permeability

Germline selection shapes human mitochondrial DNA diversity.

Approximately 2.4% of the human mitochondrial DNA (mtDNA) genome exhibits common homoplasmic genetic variation. We analyzed 12,975 whole-genome sequences to show that 45.1% of individuals from 1526 mother-offspring pairs harbor a mixed population of mtDNA (heteroplasmy), but the propensity for maternal transmission differs across the mitochondrial genome. Over one generation, we observed selection both for and against variants in specific genomic regions; known variants were more likely to be transmitted than previously unknown variants. However, new heteroplasmies were more likely to match the nuclear genetic ancestry as opposed to the ancestry of the mitochondrial genome on which the mutations occurred, validating our findings in 40,325 individuals. Thus, human mtDNA at the population level is shaped by selective forces within the female germ line under nuclear genetic control, which ensures consistency between the two independent genetic lineages.NIHR, Wellcome Trust, MRC, Genomics Englan

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility

Fluid pressures at hypocenters of moderate to large earthquakes

Many active faults are expected to develop fluid pressures in excess of hydrostatic pressures below 3 to 7 km depth during interseismic periods. Suprahydrostatic fluid pressures are known to reduce the stresses required for brittle failure. Stress differences that trigger moderate to large earthquakes typically range from 40 to 160 MPa, as indicated by earthquake shear stress drops and paleostress estimates obtained from mylonites. For stresses in this range (40–160 MPa), seismic fault reactivation requires in most cases pore fluid factors (fluid pressure/overburden pressure) higher than for hydrostatic fluid pressures (i.e., >0.37) along misoriented faults with fault angles ≥ 45°, such as many segments of the San Andreas fault system. For example, at a stress difference of 100 MPa and fault angles of 45° – 55°, fault reactivation at 7 to 20 km depth requires hypocentral pore fluid factors of ≈0.8-1 for reverse faults, 0.6–0.9 for strike-slip faults, and <0.8 for normal faults. Pore fluid factors increase with increasing cohesive strength of faults, increasing coefficient of internal friction, and increasing fault angle. Seismic reactivation of cohesive faults at stress differences of 40–160 MPa requires near the base of the seismogenic zone (≈15 km depth) suprahydrostatic fluid pressures at all possible fault angles. Pore fluid factors are ≈0.4–0.9 for normal faults, ≈0.6-1 for strike-slip faults, and ≈0.8–1.05 for thrust or reverse faults. These constraints are potentially useful for the modelling of seismic faulting and earthquake recurrence times

The Dalradian rocks of the central Grampian Highlands of Scotland

The central Grampian Highlands, as defined here, are bounded to the north-west by the Great Glen Fault, to the south-west by Loch Etive and the Pass of Brander Fault and to the south-east by the main outcrop of the Loch Tay Limestone Formation. The more arbitrary northern boundary runs north-west along the A9 road and westwards to Fort William. The detailed stratigraphy of the Dalradian Supergroup ranges from the uppermost Grampian Group through to the top of the Argyll Group, most notably seen in the two classic areas of Loch Leven–Appin and Schiehallion–Loch Tay; Southern Highland Group strata are preserved only in a small structural inlier south of Glen Lyon. Major F1 and F2 folds are complicated by co-axial northeast-trending F3 and F4 folding, as well as by locally important north- or NW-trending folds. In the Loch Leven area, nappe-like F1 folds verge to the north-west, whereas to the south-east the major recumbent F1/F2 Tay Nappe verges to the south-east. The trace of the upright Loch Awe Syncline lies between the opposing nappes, but in this region a large mass of late-Caledonian granitic rocks obscures their mutual relationship. Three tectonic ‘slides’ are identified that are certainly zones of high strain but which in part could be obscuring stratigraphical variations. The regional metamorphism ranges from greenschist facies on the western seaboard of Argyll to amphibolite facies in most of the remainder of the region. The study of garnets, together with kyanite and staurolite in the Schiehallion area, has enabled a detailed history of the metamorphism and structure to be unravelled. Stratabound mineralization occurs in the Easdale Subgroup, where there is also evidence of changes of sedimentary environment associated with volcanicity and lithospheric stretching. The region is dissected by a series of NE-trending, dominantly left-lateral, faults, subparallel to the Great Glen Fault, whose movement history is illustrated here by that of the Tyndrum Fault