A monolithic common-collector front-end optical preamplifier

A monolithic transimpedance preamplifier has been developed having a common-collector cascode configuration with shunt feedback, using an advanced bipolar IC process. The measured sensitivity was -35.0 dBm at 140 Mbit/s for an error rate of 10-9and a p-in photodiode responsivity of 0.5 A/

Physical activity and the prevention of mental illness, dysfunction and cognitive deterioration

Describes the role of physical activity in the prevention of mental illness, dysfunction and cognitive deterioration

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes

We document here that infection of prediabetic mice with a virus expressing an H-2K(b)–restricted mimic ligand to a self epitope present on β cells accelerates the development of autoimmune diabetes. Immunization with the mimic ligand expanded autoreactive T cell populations, which was followed by their trafficking to the islets, as visualized in situ by tetramer staining. In contrast, the mimic ligand did not generate sufficient autoreactive T cells in naive mice to initiate disease. Diabetes acceleration did not occur in H-2K(b)–deficient mice or in mice tolerized to the mimic ligand. Thus, arenavirus-expressed mimics of self antigens accelerate a previously established autoimmune process. Sequential heterologous viral infections might therefore act in concert to precipitate clinical autoimmune disease, even if single exposure to a viral mimic does not always cause sufficient tissue destruction