Optimization of roll calibration for flange shape rolling. Groove space

The most important component of any rolling mill is the calibration of the rolls. The ability to obtain a finished product of high quality at minimal cost depends on the right calibration. According to the previous experience and practice a large number of different calibrations for the flange profiles production are known. The universal 'concept of two-stage optimization', consisting of two successively carried out optimization stages developed in the Department of Metal Forming of the Ural Federal University in relation to optimization of the roll calibration for flange shape rolling is considered in this article. Common features of these shapes classification and their variation levels are identified and justified. This developed classification structure is the basis for the formation of spaces of groove schemes, due to which the groove space is formed. In the software implementation the groove space is represented as a 'groove database'. In the future this database will be used to form the space of calibration schemes that are fundamentally suitable for these shapes rolling. © Published under licence by IOP Publishing Ltd.The reported study was funded by RFBR according to the research project 20-38-90246

BCG-INDUCED PRO-INFLAMMATORY PHENOTYPE OF MESENCHYMAL STEM CELLS: EFFECT OF IMMUNE MODULATORS

In case of mycobacterial infection the granulomatous infiltration foci contain the significant amount of mesenchymal stem cells (MSC), which functional phenotype and respective function in anti-tuberculosis immune defense remain unknown.Goal of the study: to characterize the MSC phenotype, formed by their interaction with BCG of M. bovis and to evaluate the changes in this phenotype caused by the action of inhibitors and stimulants of immune regulatory action.Materials and methods: MSC retrieved from bone marrow of mice were cultured with the presence and absence of BCG of M. bovis and/or poludanum TLR3 agonist; and the effect of two latter on the production of pro- and anti-inflammatory cytokines was evaluated by enzyme multiplied immunoassay. Flow cytometry and radioactive testing were used to evaluate the impact of cultured BCG fluid and poludanum-conditioned MSC on the proliferative and apoptotic activity of splenocytes. The inhibitors of indoleamine 2,3-dioxygenase (IDO), cyclooxygenase-2 (COG-2) or NO synthase were added to certain cultures alone with BCG and poludanum, and the contributions of IDO, COG-2 and NO to BCG and poludanum-induced response were assessed.Results. Pro-inflammatory polarization of MSC under the action of BCG and poludanum was demonstrated. Pro-inflammatory MSC phenotype correlated to their anti-apoptogenic and growth-stimulating actions on the splenocytes. It was demonstrated that IDO and NO restrained BCG-induced polarization and conversely COG-2 promoted BCG-induced pro-inflammatory polarization of MSC.Conclusions. 1. MSC actively participate in the formation of immunologic anti-mycobacterial resistance. 2. Targeted regulation of IDO and NO production can be feasibly applied for formation of anti-tuberculous vaccinal immunity and control mycobacterial infection

Modeling of the Rolling Process of Channel No. 16 in the Expanded Grooves of a New Type

В ходе исследования был получен новый тип развернутого калибра для производства швеллеров — калибр с двойным уклоном действительных фланцев во внутрь профиля швеллера. Также было проведено компьютерное моделирование прокатки из стали 09Г2С швеллера по существующей калибровке и новой калибровке, модернизированной путем использования в ней калибров нового типа, в программном комплексе DEFORM.The groove with a double slope of the actual flanges into the channel profile was obtained. Computer simulation of channel rolling made of steel 09G2S in a new calibration with a new type of calibrations was carried. The DEFORM software package was used for thisИсследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 20-38-90246.The research was carried out with the financial support of the RFBR in the framework of scientific project No. 20-38-90246

THE OPTIMIZATION OF THE SCHEME OF METAL DEFORMATION WHILE ROLLING CHANNELS

The decrease in the magnitude of the unevenness of the deformation was chosen as one of the goals of optimizing the calibration of the rolling rolls. With the use of the universal “Concept of Optimal Calibration”, channels of channel calibers and channel calibrations are formed, and an algorithm for forming the space of channel calibrations schemes and for selecting the optimal calibration scheme.Уменьшение величины неравномерности деформации выбрано в качестве одной из целей оптимизации калибровки прокатных валков. С использованием универсальной «Концепции оптимальной калибровки» сформированы пространства швеллерных калибров и швеллерных калибровок, а также разработан алгоритм формирования пространства схем швеллерных калибровок и выбора оптимальной схемы калибровки

SELECTING THE OPTIMAL CALIBRATION OF THE ROLLERS FOR THE IMPROVEMENT OF THE STRUCTURE OF THE READY SHEVLER

Улучшение структуры готового изделия выбрано в качестве цели оптимизации калибровки прокатных валков. С использованием теории систем и теории графов сформированы пространства швеллерных калибров и швеллерных калибровок, а так же составлены матрицы смежности швеллерных калибров.The improvement in the structure of the finished product is chosen as the goal of optimizing the calibration of the rolling rolls. Using the theory of systems and the theory of graphs, spaces of channel calibers and channel calibrations are formed, and matrices of adjacent channel calibers are also made up

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain

BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent the association of SMRT with BCL6, inhibit transcriptional repression and cause apoptosis of lymphoma cells in vitro and in vivo. In order to discover compounds, which have the potential to be developed into BCL6 inhibitors, we screened a natural product library. The ansamycin antibiotic, rifamycin SV, inhibited BCL6 transcriptional repression and NMR spectroscopy confirmed a direct interaction between rifamycin SV and BCL6. To further determine the characteristics of compounds binding to BCL6-POZ we analyzed four other members of this family and showed that rifabutin, bound most strongly. An X-ray crystal structure of the rifabutin-BCL6 complex revealed that rifabutin occupies a partly non-polar pocket making interactions with tyrosine58, asparagine21 and arginine24 of the BCL6-POZ domain. Importantly these residues are also important for the interaction of BLC6 with SMRT. This work demonstrates a unique approach to developing a structure activity relationship for a compound that will form the basis of a therapeutically useful BCL6 inhibitor

Чрескожная неинвазивная вегетативная стимуляция: возможности и перспективы метода в практике специалистов по внутренним болезням

The article provides an overview of key studies on vagus nerve stimulation. The vagus nerve stimulation method affects the nerve fibers of the internal and external nerve plexuses, enhancing the parasympathetic effect. The positive therapeutic effect has been achieved in various experimental and clinical studies on the treatment of neurological and cardiac diseases, metabolic syndrome, and obesity. It has been shown that vagus nerve stimulation reduces epileptic seizures frequency, cardiac arrhythmias, and is prognostically favorable for the treatment of ischemia and reperfusion injury of the myocardium. Recent studies have examined the inflammatory reflex involved in the pathogenesis of obesity. The role of bioelectronic vagus nerve stimulation is being actively investigated for the treatment of obesity and metabolic syndrome.В статье приведен обзор ключевых исследований по стимуляции блуждающего нерва. Данный метод влияет на нервные волокна внутренних и наружных нервных сплетений, усиливая парасимпатическое действие. Благодаря такому воздействию в различных экспериментальных и клинических исследованиях достигнут положительный терапевтический эффект в лечении неврологических, кардиологических заболеваний, метаболического синдрома и ожирения. Показано, что стимуляция блуждающего нерва приводит к уменьшению количества приступов эпилепсии, нарушений ритма сердца, прогностически благоприятна для лечения ишемии и реперфузионного повреждения миокарда. В недавних исследованиях изучен воспалительный рефлекс, участвующий в патогенезе ожирения. Роль биоэлектронной стимуляции блуждающего нерва активно исследуется для лечения ожирения и метаболического синдрома