5 research outputs found
Multisynergistic Platform for Tumor Therapy by Mild Microwave Irradiation-Activated Chemotherapy and Enhanced Ablation
Microwave (MW) therapy,
as a promising type of thermal therapy,
has been attracting more and more attention from scientists. The combination
of thermal and chemotherapy is of great significance in the latest
studies of synergistic tumor therapy. However, the research on the
MW therapy mechanism, especially the nonthermal effect applied in
the combined cancer therapy, is not thorough enough. Pleasantly, we
have discovered that nonthermal MW irradiation can promote the cellular
uptake of nanoparticles and anticancer drugs <i>via</i> experiments <i>in vitro</i> and <i>in vivo</i>. Therefore, multifunctional
nanoplatforms have been designed for enhanced tumor inhibition by
loading ionic liquids (ILs), doxorubicin hydrochloride (DOX), and
phase change materials (PCMs) into ZrO<sub>2</sub> hollow nanoparticles.
PCMs act as MW switches. The as-made IL-DOX-PCM@ZrO<sub>2</sub> nanoplatforms
were injected into H22-tumor-bearing mice <i>via</i> the
tail vein. Mild microwave irradiation (0.9 W, 450 MHz) was then applied.
The thermal effect of MW could cause the temperature of the tumor
site to rise (58 °C). On the other hand, it will trigger the
MW switch to open and release DOX when the temperature is high enough.
At the same time as drug release, a MW nonthermal effect could improve
the cellular uptake of nanomaterials and anticancer drugs. The multisynergistic
effect can promote the survival rate of the IL-DOX-PCM@ZrO<sub>2</sub>+MW group to 100%. The results of the tumor therapy experiment <i>in vivo</i> demonstrated that as-made multifunctional IL-DOX-PCM@ZrO<sub>2</sub> nanoplatforms could enhance the therapeutic outcome of combined
thermal and chemotherapy under mild MW irradiation
Additional file 1: Figures S1âS5. of In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules
Figure S1. Size distribution of chitosan, chitosan/Fe3O4 and chitosan/Fe3O4@IL microcapsules were determined by a panel of more than 200 objects in Figure 1b. Figure S2. EDS spectrum of chitosan, chitosan/Fe3O4 and chitosan/Fe3O4@IL microcapsules. Figure S3. TG curve of chitosan, chitosan/Fe3O4 and chitosan/Fe3O4@IL microcapsules. Figure S4. Tumor weight in different groups of mice after various treatments indicated. Figure S5. Magnetization loops of chitosan/Fe3O4@IL microcapsules. Figure S6. FT-IR spectra of IL. (DOC 259 kb