18 research outputs found
Effect of chest tube position on the success rate of pleurodesis: A retrospective cohort study
Background: Malignant pleural effusion reduces cancer patients’ quality of life. Some experts have suggested that chest tubes should be directed posteriorly during pleurodesis. We conducted this study to clarify whether a posteriorly positioned chest tube has a better success rate than does an interlobular or anterior one.
Methods: We performed a retrospective chart review of patients undergoing pleurodesis between April 2011 and September 2016, and 86 patients were enrolled and divided into two groups based on the chest tube position: posterior (group 1) and others [interlobular and anterior (group 2)]. The primary endpoint was the success rate of pleurodesis, and the secondary endpoint was the complication rate (pain and fever). P < 0.05 was considered to be significant.
Results: In total, 66, 20 patients were included in groups 1 and 2, respectively. Complete and partial success was achieved in 57 (86%) and 15 (75%) patients in groups 1 and 2, respectively. The success rates were similar in all groups (p = 0.39). Complications were observed in 51 (77%) and 16 (80%) patients in groups 1 and 2, respectively (p = 0.99). Between the two groups, there was no statistically significant difference in terms of age and sex.
Conclusions: In malignant pleural effusion, the success rates of pleurodesis may be similar regardless of the position of the tube. However, this is a retrospective study with insufficient participants. Hence, further investigation is required
Data from: Pleural effusion biomarkers and computed tomography findings in diagnosing malignant pleural mesothelioma: a retrospective study in a single center
In this study, we aimed to examine the clinical value of the pleural effusion (PE) biomarkers, soluble mesothelin-related peptide (SMRP), cytokeratin 19 fragment (CYFRA 21-1) and carcinoembryonic antigen (CEA), and the utility of combining chest computed tomography (CT) findings with these biomarkers, in diagnosing malignant pleural mesothelioma (MPM). We conducted a retrospective cohort study in a single center. Consecutive patients with undiagnosed pleural effusions who underwent PE analysis between September 2014 and August 2016 were reviewed. This study included 240 patients (32 with MPM and 208 non-MPM). SMRP and the CYFRA 21-1/CEA ratio had a sensitivity and specificity for diagnosing MPM of 56.3% and 86.5%, and 87.5% and 74.0%, respectively. Using receiver operating characteristics (ROC) curve analysis of the ability of these markers to distinguish MPM from all other PE causes, the area under the ROC curve (AUC) for SMRP and the CYFRA 21-1/CEA ratio was 0.804 and 0.874, respectively. The sensitivity and specificity of SMRP combined with the CYFRA 21-1/CEA ratio were 93.8% and 64.9%, respectively. The sensitivity of the combination of SMRP, the CYFRA 21-1/CEA ratio, and the presence of Leung's criteria (a chest CT finding that is suggestive of malignant pleural disease) was 93.8%. In conclusion, the combined PE biomarkers had a high sensitivity for diagnosing MPM, although the addition of chest CT findings did not improve the sensitivity of SMRP combined with the CYFRA 21-1/CEA ratio. Combination of these biomarkers helped to rule out MPM effectively among patients at high risk of suffering MPM and would be valuable especially for old frail patients who have difficulty in undergoing invasive procedures such as thoracoscopy
Scholarly Activity Support Systems in Internal Medicine Residency Programs: A National Representative Survey in Japan
The CYFRA21-1/CEA ratio of the pleural effusion of MPM and non-MPM patients.
<p>The CYFRA21-1/CEA ratio of the pleural effusion of MPM and non-MPM patients.</p
Pleural effusion biomarkers and CT findings in diagnosing malignant pleural mesothelioma
Pleural effusion biomarkers and CT findings in diagnosing malignant pleural mesotheliom
Pleural effusion SMRP levels and CYFRA 21-1/CEA ratio.
<p>Pleural effusion SMRP levels and CYFRA 21-1/CEA ratio.</p
The utility of chest CT findings and pleural effusion biomarkers in diagnosing malignant pleural mesothelioma.
<p>The utility of chest CT findings and pleural effusion biomarkers in diagnosing malignant pleural mesothelioma.</p
The CYFRA21-1/CEA ratio of the pleural effusion of MPM and non-MPM patients.
<p>The CYFRA21-1/CEA ratio of the pleural effusion of MPM and non-MPM patients.</p
SMRP levels in each subgroup of patients.
<p>SMRP levels in each subgroup of patients.</p
Receiver operating characteristic (ROC) curves of SMRP and CYFRA 21-1/CEA ratio.
<p>Receiver operating characteristic (ROC) curves of SMRP and CYFRA 21-1/CEA ratio.</p