Upstream without a Paddle: Gene Patenting and the Protection of the Infostructure

The U.S. patent system, designed to protect rights to specific, marketable gadgets, has increasingly over the past few decades granted patents on comparatively abstract and amorphous ideas that stretch the system beyond recognition. Overly broad patents, and patents too far upstream from the marketplace, I argue, undermine the patent regime, hamper innovation, and prove exceedingly difficult to adjudicate. Using a series of conceptual and historical analogies, I attempt to assess the patenting of genes and other broad, upstream patents from a public policy context, emphasizing, as many are coming to realize, that things work best in the knowledge-based economy when what I describe as the infostructure —those seminal information assets needed by all players in a given high-tech sector to compete—are pooled and shared

Upstream without a Paddle: Gene Patenting and the Protection of the Infostructure

The U.S. patent system, designed to protect rights to specific, marketable gadgets, has increasingly over the past few decades granted patents on comparatively abstract and amorphous ideas that stretch the system beyond recognition. Overly broad patents, and patents too far upstream from the marketplace, I argue, undermine the patent regime, hamper innovation, and prove exceedingly difficult to adjudicate. Using a series of conceptual and historical analogies, I attempt to assess the patenting of genes and other broad, upstream patents from a public policy context, emphasizing, as many are coming to realize, that things work best in the knowledge-based economy when what I describe as the infostructure —those seminal information assets needed by all players in a given high-tech sector to compete—are pooled and shared

The climate deception dossiers: internal fossil fuel industry memos reveal decades of corporate disinformation

This report presents seven “deception dossiers”—collections containing some 85 internal company and trade association documents that have either been leaked to the public, come to light through lawsuits, or been disclosed through Freedom of Information Act (FOIA) requests. While many of these documents have been analyzed by others (Oreskes 2011; Oreskes and Conway 2010; Gelbspan 1998), these dossiers offer the most complete and up-to-date collection yet available. Excerpts of the documents are provided in the report’s appendices; the complete dossiers—totaling some 336 pages— are available online. Each collection of internal documents reviewed here reveals a separate glimpse of a coordinated campaign underwritten by the world’s major fossil fuel companies and their allies to spread climate misinformation and block climate action. The campaign began decades ago and continues today. The fossil fuel industry—like the tobacco industry before it—is noteworthy for its use of active, intentional disinformation and deception to support its political aims and maintain its lucrative profits. The following case studies show that: Fossil fuel companies have intentionally spread climate disinformation for decades. The roots of the fossil fuel companies’ deception and disinformation run deep. Internal documents dating back to the early 1990s show a series of carefully planned campaigns of deception organized by companies and by trade groups representing the industry. As the scientific evidence concerning climate change became clear, some of the world’s largest carbon producers—including BP, Chevron, ConocoPhillips, ExxonMobil, Peabody Energy, and Shell—developed or participated in campaigns to deliberately sow confusion and block policies designed to reduce the heat-trapping emissions that cause global warming. Fossil fuel company leaders knew that their products were harmful to people and the planet but still chose to actively deceive the public and deny this harm. The letters, memos, and reports in the dossiers show that company executives have known for at least two decades that their products—coal, oil, and natural gas—cause harm to people and the climate. The campaign of deception continues today. With documents made public as recently as 2014 and 2015, the evidence is clear that a campaign of deception about global warming continues to the present. Today, most major fossil fuel companies acknowledge the main findings of climate science. Many even say they support policies to cut emissions. And yet, some of these same companies continue to support groups that spread misinformation designed to deceive the public about climate science and climate policy

Operational Techniques for Dealing with Long Eclipses During the MMS Extended Mission

Launch window design for the Magnetospheric Multiscale (MMS) mission ensured that no excessive eclipses would be encountered during the prime mission. However, no orbit solutions exist that satisfy the eclipse constraints indefinitely: most extended mission years contain 1-3 eclipses long enough to potentially damage either the spacecraft or its scientific instruments. Two steps were taken to improve the situation. Firstly, raising apogee radius from 25 to 29.34 Earth radii altered the Sun-Earth-MMS phasing, so efficiently achieving reductions in the long eclipse durations. These maneuvers were performed early this year, in preparation for the first pair of long eclipses in August 2019. Secondly, a set of operational steps were taken around the time of the eclipses to help maintain spacecraft and instrument temperatures while preventing power load shedding. These operational steps included raising key onboard temperatures through adjusting the spacecraft attitude to tilt the instrument deck towards the Sun, and engaging select heaters prior to going into eclipses. In addition, all scientific instruments were turned off, as well as high-power, non-critical spacecraft systems, to conserve energy.These steps each came with trade-offs which will be discussed in the paper. Finally, the results that were obtained when the spacecraft experienced the first extremely long eclipses will be discussed, as will lessons learned for future long eclipses

Magnetospheric Multiscale Mission Micrometeoroid/Orbital Debris Impacts

The MMS spacecraft are highly instrumented (accelerometers, star cameras, Sun sensors, science experiments for plasmas etc.). This presentation will discuss how data from these systems has allowed two micrometeoroid/orbital debris events to be studied: the Feb. 2, 2016 impact with an MMS4 shunt resistor, and the June 12, 2016 impact with an MMS4 wire boom

Lessons Learned in the Livingstone 2 on Earth Observing One Flight Experiment

The Livingstone 2 (L2) model-based diagnosis software is a reusable diagnostic tool for monitoring complex systems. In 2004, L2 was integrated with the JPL Autonomous Sciencecraft Experiment (ASE) and deployed on-board Goddard's Earth Observing One (EO-1) remote sensing satellite, to monitor and diagnose the EO-1 space science instruments and imaging sequence. This paper reports on lessons learned from this flight experiment. The goals for this experiment, including validation of minimum success criteria and of a series of diagnostic scenarios, have all been successfully net. Long-term operations in space are on-going, as a test of the maturity of the system, with L2 performance remaining flawless. L2 has demonstrated the ability to track the state of the system during nominal operations, detect simulated abnormalities in operations and isolate failures to their root cause fault. Specific advances demonstrated include diagnosis of ambiguity groups rather than a single fault candidate; hypothesis revision given new sensor evidence about the state of the system; and the capability to check for faults in a dynamic system without having to wait until the system is quiescent. The major benefits of this advanced health management technology are to increase mission duration and reliability through intelligent fault protection, and robust autonomous operations with reduced dependency on supervisory operations from Earth. The work-load for operators will be reduced by telemetry of processed state-of-health information rather than raw data. The long-term vision is that of making diagnosis available to the onboard planner or executive, allowing autonomy software to re-plan in order to work around known component failures. For a system that is expected to evolve substantially over its lifetime, as for the International Space Station, the model-based approach has definite advantages over rule-based expert systems and limit-checking fault protection systems, as these do not scale well. The model-based approach facilitates reuse of the L2 diagnostic software; only the model of the system to be diagnosed and telemetry monitoring software has to be rebuilt for a new system or expanded for a growing system. The hierarchical L2 model supports modularity and expendability, and as such is suitable solution for integrated system health management as envisioned for systems-of-systems

Losing ourselves:Active inference, depersonalization, and meditation

This is the final version. Available on open access from Frontiers Media via the DOI in this recordDisruptions in the ordinary sense of selfhood underpin both pathological and “enlightened” states of consciousness. People suffering from depersonalization can experience the loss of a sense of self as devastating, often accompanied by intense feelings of alienation, fear, and hopelessness. However, for meditative contemplatives from various traditions, “selfless” experiences are highly sought after, being associated with enduring peace and joy. Little is understood about how these contrasting dysphoric and euphoric experiences should be conceptualized. In this paper, we propose a unified account of these selfless experiences within the active inference framework. Building on our recent active inference research, we propose an account of the experiences of selfhood as emerging from a temporally deep generative model. We go on to develop a view of the self as playing a central role in structuring ordinary experience by “tuning” agents to the counterfactually rich possibilities for action. Finally, we explore how depersonalization may result from an inferred loss of allostatic control and contrast this phenomenology with selfless experiences reported by meditation practitioners. We will show how, by beginning with a conception of self-modeling within an active inference framework, we have available to us a new way of conceptualizing the striking experiential similarities and important differences between these selfless experiences within a unifying theoretical framework. We will explore the implications for understanding and treating dissociative disorders, as well as elucidate both the therapeutic potential, and possible dangers, of meditation.European Union Horizon 202

Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis

Abstract Background Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. Methods Diabetic gastroparetics, diabetic non-gastroparetic controls, idiopathic gastroparetics and non-diabetic non-gastroparetic controls underwent full-thickness gastric body biopsies. Deep RNA sequencing was performed and pathway analysis of differentially expressed transcripts was done using Ingenuity®. A subset of differentially expressed genes in diabetic gastroparesis was validated in a separate cohort using QT-PCR. Results 111 genes were differentially expressed in diabetic gastroparesis and 181 in idiopathic gastroparesis with a log2fold difference of | ≥ 2| and false detection rate (FDR) < 5%. Top canonical pathways in diabetic gastroparesis included genes involved with macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, osteoarthritis pathway and differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F. Top canonical pathways in idiopathic gastroparesis included genes involved in granulocyte adhesion and diapedesis, agranulocyte adhesion and diapedesis, and role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis. Sixty-five differentially expressed genes (log2fold difference | ≥ 2|, FDR < 5%) were common in both diabetic and idiopathic gastroparesis with genes in the top 5 canonical pathways associated with immune signaling. 4/5 highly differentially expressed genes (SGK1, APOLD1, CXCR4, CXCL2, and FOS) in diabetic gastroparesis were validated in a separate cohort of patients using RT-PCR. Immune profile analysis revealed that genes associated with M1 (pro inflammatory) macrophages were enriched in tissues from idiopathic gastroparesis tissues compared to controls (p < 0.05). Conclusions Diabetic and idiopathic gastroparesis have both unique and overlapping transcriptomic signatures. Innate immune signaling likely plays a central role in pathogenesis of human gastroparesis.https://deepblue.lib.umich.edu/bitstream/2027.42/145193/1/12920_2018_Article_379.pd

Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis

Abstract Background Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. Methods Diabetic gastroparetics, diabetic non-gastroparetic controls, idiopathic gastroparetics and non-diabetic non-gastroparetic controls underwent full-thickness gastric body biopsies. Deep RNA sequencing was performed and pathway analysis of differentially expressed transcripts was done using Ingenuity®. A subset of differentially expressed genes in diabetic gastroparesis was validated in a separate cohort using QT-PCR. Results 111 genes were differentially expressed in diabetic gastroparesis and 181 in idiopathic gastroparesis with a log2fold difference of | ≥ 2| and false detection rate (FDR) < 5%. Top canonical pathways in diabetic gastroparesis included genes involved with macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, osteoarthritis pathway and differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F. Top canonical pathways in idiopathic gastroparesis included genes involved in granulocyte adhesion and diapedesis, agranulocyte adhesion and diapedesis, and role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis. Sixty-five differentially expressed genes (log2fold difference | ≥ 2|, FDR < 5%) were common in both diabetic and idiopathic gastroparesis with genes in the top 5 canonical pathways associated with immune signaling. 4/5 highly differentially expressed genes (SGK1, APOLD1, CXCR4, CXCL2, and FOS) in diabetic gastroparesis were validated in a separate cohort of patients using RT-PCR. Immune profile analysis revealed that genes associated with M1 (pro inflammatory) macrophages were enriched in tissues from idiopathic gastroparesis tissues compared to controls (p < 0.05). Conclusions Diabetic and idiopathic gastroparesis have both unique and overlapping transcriptomic signatures. Innate immune signaling likely plays a central role in pathogenesis of human gastroparesis.https://deepblue.lib.umich.edu/bitstream/2027.42/145193/1/12920_2018_Article_379.pd

Integrated System for Autonomous Science

The New Millennium Program Space Technology 6 Project Autonomous Sciencecraft software implements an integrated system for autonomous planning and execution of scientific, engineering, and spacecraft-coordination actions. A prior version of this software was reported in "The TechSat 21 Autonomous Sciencecraft Experiment" (NPO-30784), NASA Tech Briefs, Vol. 28, No. 3 (March 2004), page 33. This software is now in continuous use aboard the Earth Orbiter 1 (EO-1) spacecraft mission and is being adapted for use in the Mars Odyssey and Mars Exploration Rovers missions. This software enables EO-1 to detect and respond to such events of scientific interest as volcanic activity, flooding, and freezing and thawing of water. It uses classification algorithms to analyze imagery onboard to detect changes, including events of scientific interest. Detection of such events triggers acquisition of follow-up imagery. The mission-planning component of the software develops a response plan that accounts for visibility of targets and operational constraints. The plan is then executed under control by a task-execution component of the software that is capable of responding to anomalies