Analysis of Causes and Countermeasures of Campus Loans Based on Maslow’s Hierarchy of Needs

With the development of Internet Finance, Campus loan, as a kind of online loans, sprung up in the universities and colleges across China, bringing about some social issues that have widely attracted much concern of the public. To address those issues, the study deeply analyzed the psychological reasons of college students participated in campus loans, with the guidelines of Maslow’s Hierarchy of Needs from aspects of physical needs, safety and security needs, belonging and love needs, esteem needs, and self-actualization needs. Based on the above analysis, a comprehensive prevention system was established to discuss how to take measures from five levels, namely, individual improvement, family education, college education and social environment, so as to better solve problems and guide college students to use loans with healthy consumption perception in a legal way

Exploration on the Creative Model of Cultural Confidence Improvement for Chinese Minority College Students

With the rapid development of China, the thoughts on Socialism with Chinese Characteristics for a New Era put forward new requirements for improving minority college students’ cultural confidence. In light of this, the study constructed an improvement model, from perspectives of cultural consciousness, cultural practice, and cultural recognition, with the purpose of strengthening minority college students’ confidence on the Chinese traditional culture, Chinese revolutionary culture, socialist core values, minority culture，and Thoughts on Socialism with Chinese Characteristics for a New Era prospectively. In a creative way, a cultural practice platform was mainly built on the basis of the status analysis of cultural consciousness hold by minority students. Furthermore, strategies for cultural recognition were discussed from the objective, subjective and intermediary level, thus forming a comprehensive model for improving the cultural confidence of minority college students

Excitons in quasi-one dimensional organics: Strong correlation approximation

An exciton theory for quasi-one dimensional organic materials is developed in the framework of the Su-Schrieffer-Heeger Hamiltonian augmented by short range extended Hubbard interactions. Within a strong electron-electron correlation approximation, the exciton properties are extensively studied. Using scattering theory, we analytically obtain the exciton energy and wavefunction and derive a criterion for the existence of a $B_u$ exciton. We also systematically investigate the effect of impurities on the coherent motion of an exciton. The coherence is measured by a suitably defined electron-hole correlation function. It is shown that, for impurities with an on-site potential, a crossover behavior will occur if the impurity strength is comparable to the bandwidth of the exciton, corresponding to exciton localization. For a charged impurity with a spatially extended potential, in addition to localization the exciton will dissociate into an uncorrelated electron-hole pair when the impurity is sufficiently strong to overcome the Coulomb interaction which binds the electron-hole pair. Interchain coupling effects are also discussed by considering two polymer chains coupled through nearest-neighbor interchain hopping $t_{\perp}$ and interchain Coulomb interaction $V_{\perp}$. Within the $t$ matrix scattering formalism, for every center-of-mass momentum, we find two poles determined only by $V_{\perp}$, which correspond to the interchain excitons. Finally, the exciton state is used to study the charge transfer from a polymer chain to an adjacent dopant molecule.Comment: 24 pages, 23 eps figures, pdf file of the paper availabl

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFN gamma Induced Gene Expression and STAT1 Phosphorylation

Host defense against the parasite Toxoplasma gondii requires the cytokine interferon-gamma (IFNγ). However, Toxoplasma inhibits the host cell transcriptional response to IFNγ, which is thought to allow the parasite to establish a chronic infection. It is not known whether all strains of Toxoplasma block IFNγ-responsive transcription equally and whether this inhibition occurs solely through the modulation of STAT1 activity or whether other transcription factors are involved. We find that strains from three North American/European clonal lineages of Toxoplasma, types I, II, and III, can differentially modulate specific aspects of IFNγ signaling through the polymorphic effector proteins ROP16 and GRA15. STAT1 tyrosine phosphorylation is activated in the absence of IFNγ by the Toxoplasma kinase ROP16, but this ROP16-activated STAT1 is not transcriptionally active. Many genes induced by STAT1 can also be controlled by other transcription factors and therefore using these genes as specific readouts to determine Toxoplasma inhibition of STAT1 activity might be inappropriate. Indeed, GRA15 and ROP16 modulate the expression of subsets of IFNγ responsive genes through activation of the NF-κB/IRF1 and STAT3/6 transcription factors, respectively. However, using a stable STAT1-specific reporter cell line we show that strains from the type I, II, and III clonal lineages equally inhibit STAT1 transcriptional activity. Furthermore, all three of the clonal lineages significantly inhibit global IFNγ induced gene expression

Altered gut fungi in systemic lupus erythematosus – A pilot study

ObjectiveGut fungi, as symbiosis with the human gastrointestinal tract, may regulate physiology via multiple interactions with host cells. The plausible role of fungi in systemic lupus erythematosus (SLE) is far from clear and need to be explored.MethodsA total of 64 subjects were recruited, including SLE, rheumatoid arthritis (RA), undifferentiated connective tissue diseases (UCTDs) patients and healthy controls (HCs). Fecal samples of subjects were collected. Gut fungi and bacteria were detected by ITS sequencing and 16S rRNA gene sequencing, respectively. Alpha and beta diversities of microbiota were analyzed. Linear discriminant analysis effect size analysis was performed to identify abundance of microbiota in different groups. The correlation network between bacterial and fungal microbiota was analyzed based on Spearman correlation.ResultsGut fungal diversity and community composition exhibited significant shifts in SLE compared with UCTDs, RA and HCs. Compared with HCs, the alpha and beta diversities of fungal microbiota decreased in SLE patients. According to principal coordinates analysis results, the constitution of fungal microbiota from SLE, RA, UCTDs patients and HCs exhibited distinct differences with a clear separation between fungal microbiota. There was dysbiosis in the compositions of fungal and bacterial microbiota in the SLE patients, compared to HCs. Pezizales, Cantharellales and Pseudaleuria were enriched in SLE compared with HCs, RA and UCTDs. There was a complex relationship network between bacterial and fungal microbiota, especially Candida which was related to a variety of bacteria.ConclusionThis study presents a pilot analysis of fungal microbiota with diversity and composition in SLE, and identifies several gut fungi with different abundance patterns taxa among SLE, RA, UCTDs and HCs. Furthermore, the gut bacterial-fungal association network in SLE patients was altered compared with HCs

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Управление крутящим моментом четырехколесного ступичного двигателя на основе алгоритма распределения

Из-за нелинейной связи и неопределенности параметров нового энергетического четырехколесного ступичного двигателя сложно контролировать его крутящий момент. Для решения этой задачи предложен метод управления крутящим моментом, основанный на алгоритме распределения. Построена динамическая модель нового двигателя, в которой неизмеримые потоки, электрическая мощность и другие переменные вводятся в соответствии со степенью свободы тела. В качестве объекта исследования рассматривается четырехколесный ступичный двигатель, в качестве цели выбрана оптимальная эффективность системы привода, а алгоритм распределения используется для управления электромагнитным моментом двигателя. Результаты моделирования показывают, что при данном управлении дальность движения увеличивается, амплитуда потока статора изменяется незначительно, ток статора варьируется, стабильность скорости двигателя хорошая, а эффект управления крутящим моментом улучшается