Two-body charmed baryon decays involving decuplet baryon in the quark-diagram scheme

In the quark-diagram scheme, we study the charmed baryon decays of ${\bf B}_c\to {\bf B}^* M$, where ${\bf B}_c$ is $\Lambda_c^+$ or $\Xi_c^{+(0)}$, together with ${\bf B}^*$ ($M$) the decuplet baryon (pseudoscalar meson). It is found that only two $W$-exchange processes are allowed to contribute to ${\bf B}_c\to {\bf B}^* M$. Particularly, we predict ${\cal B}(\Lambda_c^+ \to \Sigma^{*0(+)} \pi^{+(0)})=(2.8\pm 0.4)\times 10^{-3}$, which respects the isospin symmetry. Besides, we take into account the $SU(3)$ flavor symmetry breaking, in order to explain the observation of ${\cal B}(\Lambda_c^+\to \Sigma^{*+}\eta)$. For the decays involving $\Delta^{++}(uuu)$, we predict ${\cal B}(\Lambda_c^+\to \Delta^{++} \pi^-,\Xi_c^+ \to \Delta^{++} K^-) =(7.0\pm 1.4,13.5\pm 2.7)\times 10^{-4}$ as the largest branching fractions in the singly Cabibbo-suppressed $\Lambda_c^+,\Xi_c^+\to{\bf B}^*M$ decay channels, respectively, which are accessible to the LHCb, BELLEII and BESIII experiments.Comment: 12 pages, 1 figure, 3 tables, version to appear in EPJ

Effect of land use patterns on stability and distributions of organic carbon in the hilly region of Western Sichuan, China

Soil aggregation is important for the resistance of land surfaces to erosion, and it influences the ability of soils to remain productive. At the same time, it is also an important process of carbon sequestration. The objectives of this study were to elucidate the effects of different land use patterns on soil aggregate stability and the distribution of organic carbon in different aggregate fractions in order to prove that the different land use patterns enhance soil aggregate stability. Five kinds of soil samples were collected from the hilly area of western Sichuan under different land use patterns, such as abandoned farmlands, eucalyptus plantations, Chinese fir plantations, tea plantations and loquat orchards. The results demonstrated that the five land use patterns had high proportions of aggregates at the size of >2 mm after dry sieving, and had high proportions of aggregates at the size of < 0.5 mm after wet sieving. The aggregation abilities of the soils were significantly different depending on land use patterns. Waterstable aggregate stability was highest in the Chinese fir plantations, followed by eucalyptus plantations and tea plantations. Water-stable aggregate stability was the lowest in loquat  orchards and abandoned farmlands. Except for coarse particle, soil particle contents of the same size were affected according to the different land use patterns. As the size of aggregates decreased, the organic carbon content of the soil aggregates in tea plantations increased after a decrease, and then reduced again. However, the organic carbon contents of soil aggregates in other land uses increased continuously with the decreasing size of aggregates. Organic carbon content of the soil aggregates was strongly increased in land areas that had been converted from abandoned farmland to Chinese fir plantations, tea plantations and loquat orchards, while it was decreased when abandoned farmland was converted to eucalyptus plantations. The results provided the basis of implementation of returning farmland to forest and the process of carbon sequestration in the study areas.Key words: Soil aggregate, soil aggregate fractions, soil aggregate stability, organic carbon content of the soil aggregates, land uses

Prion-like Aggregation of Mitochondrial Antiviral Signaling Protein in Lupus Patients Is Associated With Increased Levels of Type I Interferon: MAVS AGGREGATION AND TYPE I IFN IN LUPUS

Increased levels of Type I interferon (IFN-I) and IFN-I-regulated genes are found in patients with systemic lupus erythematosus (SLE) and may be central to its pathogenesis. The mitochondrial adaptor protein MAVS is a key regulator of IFN-I that undergoes a dramatic prion-like aggregation and self-propagates the activation signal from viral RNA to amplify downstream IFN production. We wondered if such MAVS aggregates might play a role in the sustained increased production of IFN-I in SLE

Parasitic modulation of host development by ubiquitin-independent protein degradation

Certain obligate parasites induce complex and substantial phenotypic changes in their hosts in ways that favor their transmission to other trophic levels. However, the mechanisms underlying these changes remain largely unknown. Here we demonstrate how SAP05 protein effectors from insect-vectored plant pathogenic phytoplasmas take control of several plant developmental processes. These effectors simultaneously prolong the host lifespan and induce witches’ broom-like proliferations of leaf and sterile shoots, organs colonized by phytoplasmas and vectors. SAP05 acts by mediating the concurrent degradation of SPL and GATA developmental regulators via a process that relies on hijacking the plant ubiquitin receptor RPN10 independent of substrate ubiquitination. RPN10 is highly conserved among eukaryotes, but SAP05 does not bind insect vector RPN10. A two-amino-acid substitution within plant RPN10 generates a functional variant that is resistant to SAP05 activities. Therefore, one effector protein enables obligate parasitic phytoplasmas to induce a plethora of developmental phenotypes in their hosts

Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients

Background The dysregulation of transforming growth factor-β (TGF-β) signaling plays a crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties. Classified as a member of the ATP-binding cassette (ABC) family, ABCA1 was previously identified by methylated DNA immunoprecipitation microarray (mDIP-Chip) to be methylated in ovarian cancer cell lines, A2780 and CP70. By microarray, it was also found to be upregulated in immortalized ovarian surface epithelial (IOSE) cells following TGF-β treatment. Thus, we hypothesized that ABCA1 may be involved in ovarian cancer and its initiation. Results We first compared the expression level of ABCA1 in IOSE cells and a panel of ovarian cancer cell lines and found that ABCA1 was expressed in HeyC2, SKOV3, MCP3, and MCP2 ovarian cancer cell lines but downregulated in A2780 and CP70 ovarian cancer cell lines. The reduced expression of ABCA1 in A2780 and CP70 cells was associated with promoter hypermethylation, as demonstrated by bisulfite pyro-sequencing. We also found that knockdown of ABCA1 increased the cholesterol level and promoted cell growth in vitro and in vivo. Further analysis of ABCA1 methylation in 76 ovarian cancer patient samples demonstrated that patients with higher ABCA1 methylation are associated with high stage (P = 0.0131) and grade (P = 0.0137). Kaplan-Meier analysis also found that patients with higher levels of methylation of ABCA1 have shorter overall survival (P = 0.019). Furthermore, tissue microarray using 55 ovarian cancer patient samples revealed that patients with a lower level of ABCA1 expression are associated with shorter progress-free survival (P = 0.038). Conclusions ABCA1 may be a tumor suppressor and is hypermethylated in a subset of ovarian cancer patients. Hypermethylation of ABCA1 is associated with poor prognosis in these patients

Conserved Alternative Splicing and Expression Patterns of Arthropod N-Cadherin

Metazoan development requires complex mechanisms to generate cells with diverse function. Alternative splicing of pre-mRNA not only expands proteomic diversity but also provides a means to regulate tissue-specific molecular expression. The N-Cadherin gene in Drosophila contains three pairs of mutually-exclusive alternatively-spliced exons (MEs). However, no significant differences among the resulting protein isoforms have been successfully demonstrated in vivo. Furthermore, while the N-Cadherin gene products exhibit a complex spatiotemporal expression pattern within embryos, its underlying mechanisms and significance remain unknown. Here, we present results that suggest a critical role for alternative splicing in producing a crucial and reproducible complexity in the expression pattern of arthropod N-Cadherin. We demonstrate that the arthropod N-Cadherin gene has maintained the three sets of MEs for over 400 million years using in silico and in vivo approaches. Expression of isoforms derived from these MEs receives precise spatiotemporal control critical during development. Both Drosophila and Tribolium use ME-13a and ME-13b in “neural” and “mesodermal” splice variants, respectively. As proteins, either ME-13a- or ME-13b-containing isoform can cell-autonomously rescue the embryonic lethality caused by genetic loss of N-Cadherin. Ectopic muscle expression of either isoform beyond the time it normally ceases leads to paralysis and lethality. Together, our results offer an example of well-conserved alternative splicing increasing cellular diversity in metazoans

Changes in Inflammatory Response after Endovascular Treatment for Type B Aortic Dissection

This present study aims to investigate the changes in the inflammatory markers after elective endovascular treatment of Type B aortic dissection with aneurysm, as related to different anatomical features of the dissection flap in the paravisceral perfusion. Consecutive patients with type B aortic dissections with elective endovascular stent graft repair were recruited and categorized into different groups. Serial plasma levels of cytokines (Interleukin-1β, -6, -8, -10, TNF-α), chemokines (MCP-1), and serum creatinine were monitored at pre-, peri- and post-operative stages. The length of stent graft employed in each surgery was retrieved and correlated with the change of all studied biochemical parameters. A control group of aortic dissected patients with conventional medication management was recruited for comparing the baseline biochemical parameters. In total, 22 endovascular treated and 16 aortic dissected patients with surveillance were recruited. The endovascular treated patients had comparable baseline levels as the non-surgical patients. There was no immediate or thirty day-mortality, and none of the surgical patients developed post-operative mesenteric ischaemia or clinically significant renal impairment. All surgical patients had detectable pro-inflammatory mediators, but none of the them showed any statistical significant surge in the peri-operative period except IL-1β and IL-6. Similar results were obtained when categorized into different groups. IL-1β and IL-6 showed maximal levels within hours of the endovascular procedure (range, 3.93 to 27.3 higher than baseline; p = 0.001), but returned to baseline 1 day post-operatively. The change of IL-1β and IL-6 at the stent graft deployment was statistically greater in longer stent graft (p>0.05). No significant changes were observed in the serum creatinine levels. In conclusion, elective endovascular repair of type B aortic dissection associated with insignificant changes in inflammatory mediators and creatinine. All levels fell toward basal levels post-operatively suggesting that thoracic endovascular aortic repair is rather less aggressive with insignificant inflammatory modulation