Designing Primary Prevention for People Living with HIV

Today, there are new reasons for a sharper focus on prevention for people living with HIV. Growing numbers of people with the disease are living more healthy, sexual lives. Recent evidence suggests that risk taking among both HIV-positive and negative people is increasing. After nearly two decades of life in the shadow of AIDS, communities are growing weary of traditional prevention messages and many people are openly grappling with difficult questions of intimacy and sex. Increasingly, people living with HIV also face multiple complex economic and substance abuse challenges that complicate prevention efforts.There is an urgent need -- and sufficient expertise -- to move forward with prevention campaigns focused on helping people living with HIV and AIDS avoid passing their infection along to others. Numerous innovative interventions for people with HIV show promise, including:a social marketing campaign for gay men and a five-session group intervention for women living with HIV in Massachusetts,a chat line for positives and a group session program for Latinas/Latinos in Los Angeles,Internet chat room interventions in Atlanta,a group session for gay Asian American-Pacific Islander Americans living with HIV in San Francisco, andPrevention Case Management programs newly funded by the Centers for Disease Control

[Un]common Language: The Corporate Appropriation of Alternative Agro-Food Frames

Discourses and arguments regarding our increasingly globalized food system include complicated issues such as sustainability, ethical trade, localized sourcing, and food justice. However, recent research has largely glossed over how broader discursive structures can simultaneously facilitate and hinder social movement action in this area. The purpose of this study is to explore broader trends in public discourse and corporate public relations in the alternative agro-food movement (AAF). We conducted a qualitative discourse analysis to identify how powerful corporate agribusinesses use salient AAF frames in organizational literature. Our findings indicate that corporations are selectively using AAF frames to garner public support and increase their consumer bases. We conclude by providing a foundation for future research and exploration of barriers and supports for AAF efforts, and making recommendations for social movement research and framing theory

South Dakota Farmer-Based Reduced Till Crop Budgets

The use of reduced tillage practices in the U.S. has expanded a great deal over the past 15 years (USDA, 1986) . In 1985, roughly a quarter of South Dakota\u27s corn acreage was reported to be under reduced tillage (S25medra and Delvo, 1986) . A 1985 survey by South Dakota State University (SDSU) showed 69% of the farmer respondents to be using some type of reduced tillage on at least part of their acreage (Allen, 1987). Primary motivations for farmers adopting reduced tillage practices are to reduce machine costs, conserve moisture, and control soil erosion losses. Problems of weed control are usually accentuated under reduced tillage. Greater expenditures for chemical weed control are almost inevitable with reduced tillage. Some studies show interconnections between reduced tillage and fertilizer nutrient requirements

Spectral decomposition of internal gravity wave sea surface height in global models

Two global ocean models ranging in horizontal resolution from 1/12° to 1/48° are used to study the space and time scales of sea surface height (SSH) signals associated with internal gravity waves (IGWs). Frequency‐horizontal wavenumber SSH spectral densities are computed over seven regions of the world ocean from two simulations of the HYbrid Coordinate Ocean Model (HYCOM) and three simulations of the Massachusetts Institute of Technology general circulation model (MITgcm). High wavenumber, high‐frequency SSH variance follows the predicted IGW linear dispersion curves. The realism of high‐frequency motions (>0.87  cpd) in the models is tested through comparison of the frequency spectral density of dynamic height variance computed from the highest‐resolution runs of each model (1/25° HYCOM and 1/48° MITgcm) with dynamic height variance frequency spectral density computed from nine in situ profiling instruments. These high‐frequency motions are of particular interest because of their contributions to the small‐scale SSH variability that will be observed on a global scale in the upcoming Surface Water and Ocean Topography (SWOT) satellite altimetry mission. The variance at supertidal frequencies can be comparable to the tidal and low‐frequency variance for high wavenumbers (length scales smaller than ∼50 km), especially in the higher‐resolution simulations. In the highest‐resolution simulations, the high‐frequency variance can be greater than the low‐frequency variance at these scales.Key PointsTwo high‐resolution ocean models compare well against data in frequency spectral density of dynamic heightSea surface height frequency‐horizontal wavenumber spectral densities show high variance along internal gravity wave dispersion curvesTwo high‐resolution ocean models give different estimates of variance in high‐frequency, high wavenumber phenomenaPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/1/jgrc22465-sup-0002-2017JC013009-fs01.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/2/jgrc22465-sup-0003-2017JC013009-fs02.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/3/jgrc22465_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/4/jgrc22465.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/5/jgrc22465-sup-0007-2017JC013009-fs06.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/6/jgrc22465-sup-0009-2017JC013009-fs08.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/7/jgrc22465-sup-0004-2017JC013009-fs03.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/8/jgrc22465-sup-0005-2017JC013009-fs04.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/9/jgrc22465-sup-0006-2017JC013009-fs05.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/10/jgrc22465-sup-0001-2017JC013009-s01.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139946/11/jgrc22465-sup-0008-2017JC013009-fs07.pd

How collective action produces psychological change and how that change endures over time: a case study of an environmental campaign

Previous research on collective action has suggested that both intra‐ and intergroup interactions are important in producing psychological change. In this study, we examine how these two forms of interaction relate to each other over time. We present results from a longitudinal ethnographic study of participation in an environmental campaign, documenting endurance and prevalence of psychological change. Participants, locals (n = 14) and self‐defined activists (n = 14), connected enduring psychological changes, such as changes in consumer behaviour and attitudes to their involvement in the environmental campaign. Thematic analysis of interviews suggested that participants linked the process of change to categorizing themselves in a new environmental‐activist way that influenced their everyday lives beyond the immediate campaign. This recategorization was a result of a conflictual intergroup relationship with the police. The intergroup interaction produced supportive within‐group relationships that facilitated the feasibility and sustainability of new world views that were maintained by staying active in the campaign. The data from the study support and extend previous research on collective action and are the basis of a model, suggesting that intragroup processes condition the effects of intergroup dynamics on sustained psychological change

Effects of grid spacing on high-frequency precipitation variance in coupled high-resolution global ocean–atmosphere models

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Light, C., Arbic, B., Martin, P., Brodeau, L., Farrar, J., Griffies, S., Kirtman, B., Laurindo, L., Menemenlis, D., Molod, A., Nelson, A., Nyadjro, E., O’Rourke, A., Shriver, J., Siqueira, L., Small, R., & Strobach, E. Effects of grid spacing on high-frequency precipitation variance in coupled high-resolution global ocean–atmosphere models. Climate Dynamics, (2022): 1–27, https://doi.org/10.1007/s00382-022-06257-6.High-frequency precipitation variance is calculated in 12 different free-running (non-data-assimilative) coupled high resolution atmosphere–ocean model simulations, an assimilative coupled atmosphere–ocean weather forecast model, and an assimilative reanalysis. The results are compared with results from satellite estimates of precipitation and rain gauge observations. An analysis of irregular sub-daily fluctuations, which was applied by Covey et al. (Geophys Res Lett 45:12514–12522, 2018. https://doi.org/10.1029/2018GL078926) to satellite products and low-resolution climate models, is applied here to rain gauges and higher-resolution models. In contrast to lower-resolution climate simulations, which Covey et al. (2018) found to be lacking with respect to variance in irregular sub-daily fluctuations, the highest-resolution simulations examined here display an irregular sub-daily fluctuation variance that lies closer to that found in satellite products. Most of the simulations used here cannot be analyzed via the Covey et al. (2018) technique, because they do not output precipitation at sub-daily intervals. Thus the remainder of the paper focuses on frequency power spectral density of precipitation and on cumulative distribution functions over time scales (2–100 days) that are still relatively “high-frequency” in the context of climate modeling. Refined atmospheric or oceanic model grid spacing is generally found to increase high-frequency precipitation variance in simulations, approaching the values derived from observations. Mesoscale-eddy-rich ocean simulations significantly increase precipitation variance only when the atmosphere grid spacing is sufficiently fine (< 0.5°). Despite the improvements noted above, all of the simulations examined here suffer from the “drizzle effect”, in which precipitation is not temporally intermittent to the extent found in observations.Support for CXL’s effort on this project was provided by a Research Experiences for Undergraduates (REU) supplement for National Science Foundation (NSF) grant OCE-1851164 to BKA, which also provided partial support for PEM. In addition, BKA acknowledges NSF grant OCE-1351837, which provided partial support for AKO, Office of Naval Research grant N00014-19-1-2712 and NASA grants NNX17AH55G, which also provided partial support for ADN, and 80NSSC20K1135. JTF’s participation, and the SPURS-II buoy data, were funded by NASA grants 80NSSC18K1494 and NNX15AG20G

Immuno-Molecular Targeted Therapy Use and Survival Benefit in Patients with Stage IVB Cervical Carcinoma in Commission on Cancer

PURPOSE: To investigate IMT use and survival in real-world stage IVB cervical cancer patients outside randomized clinical trials. METHODS: Patients diagnosed with stage IVB cervical cancer during 2013-2019 in the National Cancer Database and treated with chemotherapy (CT) ± external beam radiation (EBRT) ± intracavitary brachytherapy (ICBT) ± IMT were studied. The adjusted hazard ratio (AHR) and 95% confidence interval (CI) for risk of death were estimated in patients treated with vs. without IMT after applying propensity score analysis to balance the clinical covariates. RESULTS: There were 3164 evaluable patients, including 969 (31%) who were treated with IMT. The use of IMT increased from 11% in 2013 to 46% in 2019. Age, insurance, facility type, sites of distant metastasis, and type of first-line treatment were independently associated with using IMT. In propensity-score-balanced patients, the median survival was 18.6 vs. 13.1 months for with vs. without IMT ( CONCLUSIONS: IMT was associated with a consistent survival benefit in real-world patients with stage IVB cervical cancer

Survival disparities in non-Hispanic Black and White cervical cancer patients vary by histology and are largely explained by modifiable factors

PurposeWe investigated racial disparities in survival by histology in cervical cancer and examined the factors contributing to these disparities.MethodsNon-Hispanic Black and non-Hispanic White (hereafter known as Black and White) patients with stage I-IV cervical carcinoma diagnosed between 2004 and 2017 in the National Cancer Database were studied. Survival differences were compared using Cox modeling to estimate hazard ratio (HR) or adjusted HR (AHR) and 95% confidence interval (CI). The contribution of demographic, socioeconomic and clinical factors to the Black vs White differences in survival was estimated after applying propensity score weighting in patients with squamous cell carcinoma (SCC) or adenocarcinoma (AC).ResultsThis study included 10,111 Black and 43,252 White patients with cervical cancer. Black patients had worse survival than White cervical cancer patients (HR&nbsp;=&nbsp;1.40, 95% CI&nbsp;=&nbsp;1.35-1.45). Survival disparities between Black and White patients varied significantly by histology (HR&nbsp;=&nbsp;1.20, 95% CI&nbsp;=&nbsp;1.15-1.24 for SCC; HR&nbsp;=&nbsp;2.32, 95% CI&nbsp;=&nbsp;2.12-2.54 for AC, interaction p&nbsp;&lt;&nbsp;0.0001). After balancing the selected demographic, socioeconomic and clinical factors, survival in Black vs. White patients was no longer different in those with SCC (AHR&nbsp;=&nbsp;1.01, 95% CI 0.97-1.06) or AC (AHR&nbsp;=&nbsp;1.09, 95% CI&nbsp;=&nbsp;0.96-1.24). In SCC, the largest contributors to survival disparities were neighborhood income and insurance. In AC, age was the most significant contributor followed by neighborhood income, insurance, and stage. Diagnosis of AC (but not SCC) at ≥65&nbsp;years old was more common in Black vs. White patients (26% vs. 13%, respectively).ConclusionsHistology matters in survival disparities and diagnosis at ≥65&nbsp;years old between Black and White cervical cancer patients. These disparities were largely explained by modifiable factors

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN